Herein, we synthesized hollow cubic caves of CuO (HC) and wrapped it with N-rich graphitic C (NC), derived from a novel biogenic mixture composed of dopamine (DA) and purine. The synthesized NC wrapped HC (NC@HC) sensor shows enhanced electrocatalytic efficacy compared to unwrapped CuO with shapes including HC, sponge (SP), cabbage (CB), and solid icy cubes (SC). The shape and composition of synthesized materials were confirmed through field-emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD), Raman spectroscopy, and X-ray photoelectron spectroscopy (XPS), whereas interfacial surface energy was calculated through contact angle measurement. The designed NC@HC sensor shows a remarkable response toward the simultaneous detection of uric acid (UA) and xanthine (Xn) with detection limits of 0.017 ± 0.001 (S/N of 3) and 0.004 ± 0.001 μM (S/N of 3), respectively. In addition, this platform was successfully applied to monitor UA from the gout patient serum. To the best of our knowledge, this is the first report on using such novel NC@HC materials for the simultaneous monitoring of UA and Xn.The recent development of a functional model of photosystem II (PSII) has paved a new way to connect the PSII model with a functional model of photosystem I (PSI). However, PSI functional models have yet to be reported. We report herein the first potential functional model of PSI, in which plastoquinol (PQH2) analogues were oxidized to plastoquinone (PQ) analogues, accompanied by hydrogen (H2) evolution. Photoirradiation of a deaerated acetonitrile (MeCN) solution containing hydroquinone derivatives (X-QH2) as a hydrogen source, 9-mesityl-10-methylacridinium ion (Acr+-Mes) as a photoredox catalyst, and a cobalt(III) complex, CoIII(dmgH)2pyCl (dmgH = dimethylglyoximate monoanion; py = pyridine) as a redox catalyst resulted in the evolution of H2 and formation of the corresponding p-benzoquinone derivatives (X-Q) quantitatively. The maximum quantum yield for photocatalytic H2 evolution from tetrachlorohydroquinone (Cl4QH2) with Acr+-Mes and CoIII(dmgH)2pyCl and H2O in deaerated MeCN was determined to be 10%. Photocatalytic H2 evolution is started by electron transfer (ET) from Cl4QH2 to the triplet ET state of Acr+-Mes to produce Cl4QH2•+ and Acr•-Mes with a rate constant of 7.2 × 107 M-1 s-1, followed by ET from Acr•-Mes to CoIII(dmgH)2pyCl to produce [CoII(dmgH)2pyCl]-, accompanied by the regeneration of Acr+-Mes. On the other hand, Cl4QH2•+ is deprotonated to produce Cl4QH•, which transfers either a hydrogen-atom transfer or a proton-coupled electron transfer to [CoII(dmgH)2pyCl]- to produce a cobalt(III) hydride complex, [CoIII(H)(dmgH)2pyCl]-, which reacts with H+ to evolve H2, accompanied by the regeneration of CoIII(dmgH)2pyCl. The formation of [CoII(dmgH)2pyCl]- was detected by electron paramagnetic resonance measurements.COVID-19 derives from infection with Coronavirus [severe acute respiratory syndrome (SARS)-CoV-2] and is associated with high morbidity and mortality due to release of a storm of pro-inflammatory cytokines and thrombogenic agents resulting in destruction of the lungs. Many reports indicate that a considerable number of patients who are positive for SARS-CoV-2 are asymptomatic or have mild symptoms. However, increasing evidence suggests that many such patients who either recovered from or had mild symptoms after COVID-19 exhibit diffuse, multiorgan, symptoms months after the infection. Verubecestat These symptoms include malaise, myalgias, chest tightness, brain fog and other neuropsychiatric symptoms that were originally reported in children and named Multisystem Inflammatory Syndrome (MIS-C). Now the US Center for Disease Control (CDC) announced the recognition of a similar condition in adults, named Multisystem Inflammatory Syndrome (MIS-A). The symptoms characterizing these conditions are very similar to those associated with Mast Cell Activation Syndrome (MCAS, US ICD-110 code D89.42-idiopathic mast cell activation syndrome). Hence, the possibility of MCAS should be evaluated in any patient with MIS and/or multisystem inflammatory symptoms. In either case, these syndromes should be addressed with liposomal formulation (in olive pomace oil) of the flavone luteolin (e.g. PureLut® or FibroProtek®) together with the antihistamine rupatadine, which also has anti-platelet activating factor (PAF) activity and inhibits mast cells that have been implicated in the pathogenesis of cytokine storms in COVID-19.COVID-19 disparities prompt Medicare to call for stronger emphasis on value-based care.Texas Supreme Court decision carries new implications for periodic payment of future medical expenses.While the World Health Organization estimates that climate change will cause approximately 250,000 additional deaths per year worldwide from malnutrition, malaria, diarrhea, and heat stress, these estimates are based on assumptions using models that have not been validated using real world, observational data.Human health is inextricably connected with the health of the environment. Our actions to reduce the threats of climate change and global warming are key to our well-being and survival.Regardless of whether education takes place virtually or in-person, Texas school vaccination rules remain in effect for the 2020-21 school year, according to the Texas Department of State Health Services. All Texas public schools (and most private schools) and colleges require students to have certain shots before they can attend classes at the beginning of a school year.Catching COVID-19 helped family physician Tim Martindale, MD, find new ways to help his patients.COVID-19 reveals longstanding health inequities among minority patients.COVID-19 has forced GME programs and medical students to make last-minute adjustments in the resident selection process.During polyomavirus (PyV) infection, host proteins localize to subnuclear domains, termed viral replication centers (VRCs), to mediate viral genome replication. Although the protein composition and spatial organization of VRCs have been described using high-resolution immunofluorescence microscopy, little is known about the temporal dynamics of VRC formation over the course of infection. We used live cell fluorescence microscopy to analyze VRC formation during murine PyV (MuPyV) infection of a mouse fibroblast cell line that constitutively expresses a GFP-tagged replication protein A complex subunit (GFP-RPA32). The RPA complex forms a heterotrimer (RPA70/32/14) that regulates cellular DNA replication and repair and is a known VRC component. We validated previous observations that GFP-RPA32 relocalized to sites of cellular DNA damage in uninfected cells and to VRCs in MuPyV-infected cells. We then used GFP-RPA32 as a marker of VRC formation and expansion during live cell microscopy of infected cells. VRC formation occurred at variable times post-infection, but the rate of VRC expansion was similar between cells.