In conclusion, spinopelvic parameters presented a discrete association with lumbar disc composition and water content. Opening the blood-brain barrier (BBB) with focused ultrasound and microbubbles (MBs) has potential use in non-invasive targeted therapy for central nervous system (CNS) diseases. Rapid short-pulse (RaSP) ultrasound with a microsecond sequence has been proposed as a minimally disruptive and efficient method for opening the BBB. This work aimed to test the feasibility and safety of BBB opening in a non-human primate model using combined RaSP ultrasound sequence and MBs. The BBB of 2 rhesus macaques were opened with RaSP and the commonly used 10 millisecond long pulse (LP), combined with microbubble (SonoVueTM, 0.2 µL/g) injection in a bolus. Elacestrant The transducer's central frequency was 300 kHz, and the acoustic pressure was set to 0.56 MPa calibrated in water. The BBB opening procedure was guided and evaluated with contrast-enhanced magnetic resonance imaging. The relative signal enhancement was compared between RaSP and LP sonication. T2-weighted fast-spin echo (FSE) and T2*-weighted gradient echo (GRE) sequences were scanned to evaluate edema and micro-bleeding at the end of the procedure. The relative signal enhancement was significantly higher (P<0.01) in the focal area compared to a similar area of the opposite hemisphere at all time points after sonication in each monkey, indicating the successful opening of the BBB. The relative signal enhancement in RaSP reached more than 60% of that with LP in our experiment, while the energy deposition was only 6% of LP. No edema or hemorrhage was found on magnetic resonance images after RaSP. Combined RaSP ultrasound and MBs for the BBB opening is a practical method in large animal models.Combined RaSP ultrasound and MBs for the BBB opening is a practical method in large animal models. The present study aimed to investigate the visibility of small ossicle parts/landmarks on high-resolution computed tomography (HRCT)/3D reconstruction (3D) to investigate what improvements in scanning resolution are needed before accurate 3D printing of patient-specific ossicles is possible. A total of 24 patients with sudden deafness sought consultation at the Department of Otorhinolaryngology Head and Neck Surgery at the Sixth Medical Center of People's Liberation Army General Hospital between October 2013 and June 2014 were enrolled in the study. All participants underwent a 256-slice spiral HRCT temporal bone axial scan, yielding a Digital Imaging and Communications in Medicine documents series. These documents were then inputted into Mimics 16.0 interactive medical image processing software for data conversion and the creation of 3D segmentation and visualizations of the ossicles. Finally, the 3D images were compared using multiplanar reformation (MPR) and 3D volume-rendering (VR) reconstructed image MPR (76.4%) and 3D VR reconstruction (52.8%), with a κ-value <0.4. The accuracy of the visualization of the malleus and incus after restoration via Mimics 16.0 software, based on temporal bone HRCT data, was high, and the degree of restoration was good. However, the accuracy and degree of restoration of the stapes footplate require further improvement.The accuracy of the visualization of the malleus and incus after restoration via Mimics 16.0 software, based on temporal bone HRCT data, was high, and the degree of restoration was good. However, the accuracy and degree of restoration of the stapes footplate require further improvement. It has been identified that two-dimensional speckle-tracking imaging (2D-STI) enables the early detection of left ventricular (LV) systolic dysfunction. This study's objective was to evaluate the frequency of impaired LV global longitudinal strain (GLS) and investigate the factors in end-stage renal disease (ESRD) patients with preserved LV ejection fraction (LVEF) associated with the impaired GLS. A total of 100 ESRD patients with preserved LVEF who underwent transthoracic echocardiography (TTE) were studied. The GLS was calculated as the average of peak longitudinal strain from 18 myocardial segments obtained utilizing the three-standard apical imagings. According to a predefined cutoff, a GLS absolute value of less than 18% was considered subclinical LV systolic dysfunction. Impaired LV GLS <18% was detected in 58 participants (58/100, 58%). Multivariate analysis exhibited that increased LV mass index was independently associated with impaired GLS <18% [odds ratio (OR) 1.028, 95% confidence interval (CI) 1.004-1.052, P=0.020]. For sequential logistic regression models, model 1, based on parameters included in multivariate logistic regression (χ =30.0), was improved by the addition of the LV mass index (χ =37.4, P<0.01). The frequency of impaired LV GLS in ESRD patients with preserved LVEF was relatively high. An increased LVEF was independently associated with impaired LV GLS.The frequency of impaired LV GLS in ESRD patients with preserved LVEF was relatively high. An increased LVEF was independently associated with impaired LV GLS. Cerebral perfusion pressure (CPP) calculated by mean arterial pressure (MAP) minus intracranial pressure (ICP) is related to blood flow into the brain and reflects cerebral ischemia and oxygenation indirectly. Near-infrared spectroscopy (NIRS) can assess cerebral ischemia and hypoxia non-invasively and has been widely used in neuroscience. However, the correlation between CPP and NIRS, and its potential application in traumatic brain injury, has seldom been investigated. We used a novel wireless NIRS system and commercial ICP and MAP devices to assess the trauma to rat brains using different impact intensity. The relationship between CPP and NIRS parameters with increasing impact strength were investigated. The results showed that changes in CPP (∆CPP), oxy-hemoglobin ∆[HbO ], total-hemoglobin ∆[HbT], and deoxy-hemoglobin were inversely proportional to the increase in impact intensity, and the correlations between ∆CPP, NIRS parameters ∆[HbO ], and ∆[HbT] were significant. The NIRS system can assess cerebral ischemia and oxygenation non-invasively and changes of HbO and HbT may be used as reference parameters to assess the level of CPP in an animal model of traumatic brain injury.