The proposed method is demonstrated in simulation studies and an application to a breast cancer clinical study in which the proposed method was shown to detect the much larger numbers of significant biomarkers than existing standard methods. © 2020 The International Biometric Society.Having been given the opportunity to write this article about Jean Bousquet is certainly an honour and an absolute pleasure. Jean - born in 1946 -hassurely everything that is neededto become a Legend.This term is usually reserved for a famous person of ancient times,however,Jeanis certainly not ancient,given that he isso extremely alert and up to date. This article is protected by copyright. All rights reserved.BACKGROUND Aim of the present study was to ascertain if a combination of leukocyte and platelet-rich fibrin (L-PRF) + autogenous bone graft (ABG) may be a clinically "non-inferior" treatment modality as compared with the association of Enamel Matrix Derivative (EMD) with ABG in the management of intrabony defects (IBDs). METHODS Forty-four patients, exhibiting at least one unfavourable intraosseous defect, were treated by L-PRF associated with ABG (22 patients; test group) or EMD+ABG (control group) in each defect. At baseline and 12 months, a complete clinical and radiographic examination was done. Pre- and post-therapy clinical (probing pocket depth [PPD], clinical attachment level [CAL], gingival recession [GR]) and radiographic (defect Bone level [(DBL)] parameters for the different treatments were compared. To guarantee the test treatment's efficacy 1mm was chosen as non-inferiority margin; for clinical relevance, a second non-inferiority margin = 0.5mm was set. RESULTS Clinical and radiographic parameters significantly improved 12 months after surgery in both test and control sites, without inter-groups differences for each measurement. The control group - test group differences for the parameters CAL gain -0.248mm (-0.618 to 0.122), PPD Reduction -0.397mm (-0.810 to 0.015), GR Change 0.059mm (-0.300 to 0.418), DBL Gain -0.250mm (-0.746 to 0.246) were all within the non-inferiority margin of 0.5 mm. CONCLUSION Our results suggest that the L-PRF+ABG combined treatment of non-contained intrabony defects produces non-inferior results in terms of CAL gain, PPD reduction, GR increase and DBL gain in comparison with the EMD+ABG combination. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.Hidradenitis suppurativa (HS) is a chronic inflammatory condition of apocrine gland-bearing skin that is characterised by recurrent painful nodules, abscess and sinus tract formation. Estimates of the prevalence of HS are highly variable, but it is believed to affect around 1% of the population in Europe. Existing treatments for HS include antimicrobial, immunomodulatory and immunosuppressive agents. This article is protected by copyright. All rights reserved.The continuously growing interest in the study of gender medicine in the last years has led to increased awareness of the differences between men and women in the clinical presentation, pathophysiology, management, and prognosis of a wide variety of diseases, including skin diseases. Gender differences in disease characteristics can be influenced by numerous factors, e.g. the effect of sex hormones, anatomy, physiology, and genetics. Variances in skin structure and physiology between the sexes can also contribute to different expressions of certain skin disorders. This article is protected by copyright. All rights reserved.The prevalence of spondyloarthritis (SpA) reported among patients with hidradenitis suppurativa (HS) ranges from 2.3 to 28.2 %, depending on the diagnostic method used.1 A key feature of SpA and one of the European Spondyloarthropathy Study Group (ESSG) diagnostic criteria for this group of diseases is enthesitis; inflammation at insertion of tendons, ligaments, and capsules. However, pain at an entheseal site is non-specific and does not always indicate inflammation. This article is protected by copyright. All rights reserved.OBJECTIVES Patients undergoing hip fracture surgery have a 10 times increased risk of stroke compared with the general population. We aimed to evaluate the association between the CHA2 DS2 -VASc (congestive heart failure, hypertension, age ≥75 years, diabetes, previous stroke/TIA [transient ischemic attack]/systemic embolism (2 points), vascular disease, age 65-74 years, and female sex) score and the risk of stroke, thromboembolism, and all-cause mortality in patients with hip fracture with or without atrial fibrillation (AF). DESIGN Nationwide prospective cohort study. SETTING Danish hospitals. PARTICIPANTS Subjects were all incident hip fracture patients in Denmark age 65 years and older with surgical repair procedures between 2004 and 2016 (n = 78,096). read more Participants were identified using the Danish Multidisciplinary Hip Fracture Registry. MEASUREMENTS We calculated incidence rates, cumulative incidences, and hazard ratios (HRs) with 95% confidence intervals (CIs) by CHA2 DS2 -VASc score, stratified on AF hctive of AF. © 2020 The American Geriatrics Society.OBJECTIVES To investigate the association of the utilization of Medicare-certified home health agency (CHHA) services with post-acute skilled nursing facility (SNF) discharge outcomes that included home time, rehospitalization, SNF readmission, and mortality. DESIGN Retrospective cohort study. SETTING New York State fee-for-service Medicare beneficiaries aged 65 years and older admitted to SNFs for post-acute care and discharged to the community in 2014. PARTICIPANTS A total of 25,357 older adults. MEASUREMENTS The outcomes included days spent alive in the community ("home time"), rehospitalization, SNF readmission, and mortality within 30- and 90-day post-SNF discharge periods. The primary independent variables were SNF five-star overall quality rating and receipt of CHHA services within 7 days of SNF discharge. Zero-inflated negative binomial regression and logistic regression models characterized the association of CHHA linkage with home time and other outcomes, respectively. RESULTS Following SNF discharge, 17,657 (69.