Furthermore, the performance of the proposed scheme is verified through performance evaluation based on the precision, recall, and F-measure.In public, the role of a fire alarm is to induce a person to a certain recognition of potential danger, resulting in that person taking appropriate evacuation action. Unfortunately, the sound of the fire alarm is not internationally standardized yet, except for recommending the use of a signal with a regular temporal pattern (or T-3 pattern). To identify the effective alarm sound, the present study investigated a relationship between acoustic characteristics of the fire alarm and its subjective psychoacoustic recognition and objective electroencephalography (EEG) responses for 50 young and older listeners. As the stimuli, six different types of alarms were applied bell, slow whoop, T-3 520 Hz, T-3 3100 Hz, and two simulated T-3 sounds (i.e., 520 and 3100 Hz) to which older adults with age-related hearing loss seemed to hear. While listening to the sounds, the EEG was recorded by each individual. The psychoacoustic recognition was also evaluated by using a questionnaire consisting of three subcategories, i.e., arousal, urgency, and immersion. The subjective responses resulted in a statistically significant difference between the types of sound. In particular, the fire alarms had acoustic features of high frequency or gradually increased frequencies such as T-3 3100 Hz, bell, and slow whoop, representing effective sounds to induce high arousal and urgency, although they also showed a limitation in being widely transmitted and vulnerable to background noise environment. Interestingly, there was a meaningful interaction effect between the sounds and age groups for the urgency and immersion, indicating that the bell was quite highly recognized in older adults. In general, EEG data showed that alpha power was decreased and gamma power was increased in all sounds, which means a relationship with negative emotions such as high arousal and urgency. Based on the current findings, we suggest using fire alarm sounds with acoustic features of high frequencies in indoor and/or public places.The influence of errors in the processes of detection and then reduction of surface topography measurement noise is of great importance; many research papers are concerned with the definition of this type of measurement error. This paper presents the influence of high-frequency measurement noise, defined for various types of surface textures, e.g., two-process plateau-honed, turned, ground, or isotropic. Procedures for the processing of raw measured data as a detection of the high-frequency errors from the results of surface topography measurements were proposed and verified (compared) according to the commonly used (available in the commercial software of the measuring equipment) algorithms. It was assumed that commonly used noise-separation algorithms did not always provide consistent results for two process textures with the valley-extraction analysis; as a result, some free-of-dimple (part of the analyzed detail where dimples do not exist) areas were not carefully considered. Moreover, the influence of measured data processing errors on surface topography parameter calculation was not comprehensively studied with high-frequency measurement noise assessments. It was assumed that the application of the Wavelet Noise Extraction Procedure (WNEP) might be exceedingly valuable when the reduction of a disparate range of measured frequencies (measurement noise) was carefully considered.Calbindin-D28k (CB), a calcium-binding protein, mediates diverse neuronal functions. In this study, adult gerbils were fed a normal diet (ND) or exposed to intermittent fasting (IF) for three months, and were randomly assigned to sham or ischemia operated groups. Ischemic injury was induced by transient forebrain ischemia for 5 min. Short-term memory was examined via passive avoidance test. CB expression was investigated in the Cornu Ammonis 1 (CA1) region of the hippocampus via western blot analysis and immunohistochemistry. Finally, histological analysis was used to assess neuroprotection and gliosis (microgliosis and astrogliosis) in the CA1 region. Short-term memory did not vary significantly between ischemic gerbils with IF and those exposed to ND. CB expression was increased significantly in the CA1 pyramidal neurons of ischemic gerbils with IF compared with that of gerbils fed ND. However, the CB expression was significantly decreased in ischemic gerbils with IF, similarly to that of ischemic gerbils exposed to ND. The CA1 pyramidal neurons were not protected from ischemic injury in both groups, and gliosis (astrogliosis and microgliosis) was gradually increased with time after ischemia. selleck inhibitor In addition, immunoglobulin G was leaked into the CA1 parenchyma from blood vessels and gradually increased with time after ischemic insult in both groups. Taken together, our study suggests that IF for three months increases CB expression in hippocampal CA1 pyramidal neurons; however, the CA1 pyramidal neurons are not protected from transient forebrain ischemia. This failure in neuroprotection may be attributed to disruption of the blood-brain barrier, which triggers gliosis after ischemic insults.(1) Background Chronic obstructive pulmonary disease (COPD) is the leading cause of morbidity and mortality worldwide. Diabetes mellitus (DM) has been shown to have adverse inflammatory effects on lung anatomy and physiology. We investigated the impact of DM on COPD patient outcomes during inpatient hospitalization. (2) Methods We conducted a retrospective analysis using the Nationwide Inpatient Sample (NIS) over the years 2002-2014. Three groups, COPD without diabetes, COPD with diabetes but no complication, and COPD with DM and complication, were analyzed. (3) Results A total of 7,498,577 were COPD hospitalization; of those, 1,799,637 had DM without complications, and 483,467 had DM with complications. After adjusting for clinical, demographic, and comorbidities, the odds of increased LOS in the COPD/DM with complication were 1.37 (confidence interval (CI) 1.326-1.368), and those of DM without complication were 1.061 (1.052-1.070) when compared with COPD alone. The odds of pneumonia, respiratory failure, stroke, and acute kidney injury were also higher in COPD hospitalizations with DM.