Dual targeted therapy in HER2-positive breast cancer cells with the combination of carbon dots/HER3 siRNA and Trastuzumab resulted in enhanced antitumor activity, which overcomes the resistance to Trastuzumab monotherapy. Herein, we have developed branched polyethylenimine functionalized carbon dots (BP-CDs) nanocarriers, which exhibited efficient GFP gene delivery and expression. The positively charged BP-CDs allowed for an effective nucleic acid binding and displayed a high-efficient small interfering RNA (siRNA)-mediated delivery targeting of cancer cells. The transfection of BP-CDs and HER3 siRNA complexes down-regulated HER3 protein expression and induced significant cell growth inhibition in BT-474 cells. BP-CDs/HER3 siRNA complexes induced cell death of BT-474 cells through G0/G1 cell cycle arrest and apoptosis. The combined treatment of BP-CDs/HER3 siRNA complexes and Trastuzumab caused greater cell growth suppression in BT-474 cells when compared to either agent alone. The findings suggest that this dual targeted therapy with the combination of BP-CDs/HER3 siRNA and Trastuzumab represents a promising approach in breast cancer. © 2020 IOP Publishing Ltd.TOPAS-nBio was used to simulate, collision-to-collision, the complete trajectories of electrons in water generated during the explicit simulation of 64Cu decay. S-values and direct damage to the DNA were calculated representing the cell (C) and the cell nucleus (N) with concentric spheres of 5 μm and 4 μm in radius, respectively. The considered "target"←"source" configurations, including the cell surface (Cs) and cytoplasm (Cy), were C←C, C←Cs, N←N, N←Cy and N←Cs. Ionization cluster size distributions were also calculated in a cylinder immersed in water corresponding to a DNA segment of 10 base-pairs in length (diameter 2.3 nm, length 3.4 nm), modeling a radioactive point source moving from the central axis to the edge of the cylinder. For that, the first moment (M1) and cumulative probability of having a cluster size of 2 or more ionizations in the cylindrical volume (F2) were obtained. Finally, the direct damage to the DNA was estimated by quantifying double-strand breaks (DSBs) using the clustering algorit in the cell, the dose being higher when 64Cu is internalized in the cell nucleus, which is reinforced by the nanodosimetric study by the presence of DNA DSBs attributable to the Auger electrons emitted during the decay of 64Cu. © 2020 Institute of Physics and Engineering in Medicine.Iridate oxides display exotic physical properties that arise from the interplay between a large spin-orbit coupling and electron correlations. Here, we present a comprehensive study of the effects of hydrostatic pressure on the electronic transport properties of SrIrO3 (SIO), a system that has recently attracted a lot of attention as potential correlated Dirac semimetal. Ruxotemitide concentration Our investigations on untwinned thin films of SIO reveal that the electrical resistivity of this material is intrinsically anisotropic and controlled by the orthorhombic distortion of the perovskite unit cell. These effects provide another evidence for the strong coupling between the electronic and lattice degrees of freedom in this class of compounds. Upon increasing pressure, a systematic increase of the transport anisotropies is observed. The anomalous pressure-induced changes of the resistivity cannot be accounted for by the pressure dependence of the density of the electron charge carriers, as inferred from Hall effect measurements. Moreover, pressure-induced rotations of the IrO6 octahedra likely occur within the distorted perovskite unit cell and affect electron mobility of this system. Creative Commons Attribution license.A double-sided nanoimprint lithography metal transfer method has been developed to fabricate a flexible capacitive touch sensor. The electrodes of this sensor are aligned and overlapped to each other and consist of a diamond aluminum mesh, which achieved a transmittance of 94% and anisotropic surface resistivity. The maximum capacitance change of the touch sensor unit is up to 41.8% when fullly touched. 3×3 sensor array was tested to prove a good touch detection function and the potential for a large-scale applications. © 2020 IOP Publishing Ltd.In-situ and real-time ultra-sensitive monitoring for the degradation process of environmental pollutants is always an important issue concerned by people. Herein, a multifunctional magnetic metal-organic framework (MOF)-based composite has been successfully constructed and applied in monitoring the disposal of cationic dyes. Owing to its particular MOFs shell and internal gold particles, the composite can be used as an efficient SERS substrate to ultra-sensitively detect the cationic dyes. Furthermore, the prepared MOF-based composite is also a peroxidase-like nanozyme, which can catalytically degrade the adsorbed cationic dyes. Additionally, the magnetic core in the MOF-based composite offers a good magnetic separation capacity, which makes a facile and rapid separation of the catalyst from the reacted solution for recyclability. This work has provided a new way to monitor the catalytic degradation process by SERS technique in the co-existence of catalyst and dye molecules in the reaction system, which can effectively eliminate the absorption of the catalyst compared with the UV-vis technique, showing promising applications in in-situ and real-time pollution disposal monitoring. © 2020 IOP Publishing Ltd.Strain engineering of germanium has recently attracted tremendous research interest. The primary goal of this approach is to exploit mechanical strain to tune the electrical and optical properties of Ge to ultimately achieve an on-chip light source compatible with silicon technology. Additionally, this can result in enhanced electrical performance for high-speed optoelectronic applications. In this paper, we demonstrate the formation of highly tensile-strained Ge islands grown on a pre-patterned (110) GaAs substrate using a depth controlled nanoindentation process. Results show that a biaxial tensile strain, up to ~2%, can be transferred from the mechanically stamped substrate to Ge islands by optimizing the parameters of the nanoindentation process. We verified our measurements by observing the islands' photoluminescence (PL) emission properties. A strong emission at room-temperature was observed around the wavelength of 1.9 µm (650 meV). This strain-induced redshift of the PL spectra is consistent with theoretical predictions, revealing a direct Ge bandgap formation.