on better than a standard ISB. drks.de identifier DRKS00011787.drks.de identifier DRKS00011787. Corticosteroids can reduce pain but the optimal dose and safety profiles are still uncertain. This study aimed to evaluate two different doses of dexamethasone for pain management and their side effects after total knee arthroplasty. A prospective randomised, controlled trial. A tertiary teaching hospital in Hong Kong. One hundred and forty-six patients were randomly allocated to one of three study groups. Before operation, patients in group D8, D16 and P received dexamethasone 8 mg, dexamethasone 16 mg and placebo (0.9% saline), respectively. The primary outcome was postoperative pain score. Secondary outcomes were opioid consumption, physical parameters of the knees and side effects of dexamethasone. Compared with placebo, group D16 patients had significantly less pain during maximal active flexion on postoperative day 3 [-1.3 (95% CI, -2.2 to -0.31), P = 0.005]. There was also a significant dose-dependent trend between pain scores and dexamethasone dose (P = 0.002). Compared with placebo, pion of the knee was found. ClinicalTrials.gov identifier NCT02767882.ClinicalTrials.gov identifier NCT02767882. Excess submental fat (SMF) can cause submental fullness resulting in negative perceptions of individuals. However, the impact of SMF on perceptions of social traits has not been well studied. To characterize the impact of SMF on external value judgments in adults in the United States. Respondents completed an online survey in which they reacted to statements about individuals with varying grades of SMF. Attributes were rated on a scale from 0 to 100 with higher scores for more positive attributes. Similar proportions of respondents (N = 1996) indicated that women and men with double chins were less attractive than those without (91% and 90%, respectively). A double chin was more likely to be noticed on a woman than on a man (78% of respondents). With increasing SMF, individuals were perceived as significantly less likeable, intelligent, happy, active, and easygoing. Those with greater amounts of SMF were rated as significantly less attractive than those with less SMF. For all attributes, male respondents rated all individuals lower than female respondents did. Results from this study provide further evidence of negative perceptions of individuals with SMF. Aesthetics of the submental area, especially SMF, likely impact the overall assessment of attractiveness and social attributes.Results from this study provide further evidence of negative perceptions of individuals with SMF. Aesthetics of the submental area, especially SMF, likely impact the overall assessment of attractiveness and social attributes. With weight loss increasingly occurring against a background of obesity across a variety of advanced cancers, there has been increasing interest in computed tomography (CT)-derived body composition analysis. ERK inhibitor Various imaging software packages and thresholds are commonly in use in CT-derived body composition analysis. This review discusses the current research in field of body composition with emphasis on the information required for such measurements to be taken into routine clinical practice. CT is widely used for tumour staging in patients with cancer. Over the last decade, this imaging modality has been exploited to make measurements of body composition. Using a common landmark (L3) several different thresholds have been developed to stratify adipose and muscle tissue areas according to age, sex and BMI and their relationship with survival. A significant relationship between CT-derived body composition and clinical outcomes has been shown in different tumour types and geographical locations. However, thally accepted terminology, software, muscle group selection, prognostic thresholds to standardize such body composition analysis.A retraction notice for the article “Abrupt and Severe Obsessive-Compulsive Disorder in an 11-Year-Old Girl-PANDAS/PANS Syndrome An Entity to be Considered-Management Implications,”2 originally published in the June/July 2020 issue of the Journal of Developmental & Behavioral Pediatrics, was itself published in the September 2020 issue. The concluding line of this notice should have read “This manuscript was published in error by the journal prior to peer review and is not the result of any fault or error from the authors.”A retraction notice for the article “Sudden Complex Hallucinations in a 14-Year-Old Girl Schizophrenia Spectrum Disorders versus Dissociative Disorders-The Influence of Early Life Experiences on Future Mental Health,”2 originally published in online on June 10, 2020, for the Journal of Developmental & Behavioral Pediatrics, was itself published in the September 2020 issue. The concluding line of this notice should have read “This manuscript was published in error by the journal prior to peer review and is not the result of any fault or error from the authors.” Over half of all patients with severe asthma have chronic rhinosinusitis (CRS). Although distinct and specialized in function and form, the upper and lower airways share similar and inter-related pathophysiologic mechanisms. The severity of CRS particularly in patients with nasal polyps can correlate with that of asthma and vice versa. The purpose of this review is to elucidate the relationship between these conditions and summarize key elements in the management of these patients. Several advances have been made in the evaluation and treatment of patients with CRS and asthma. Further understanding of inflammatory endotypes common to both CRS and severe asthma hopefully will provide appropriate and effective treatments and improve patient outcomes. CRS significantly impairs quality of life, and therapies are targeted toward improving patient symptoms, and hopefully in the future, treating the underlying immune dysfunction. Management of CRS and severe asthma requires a multidisciplinary approach. Further real-world studies are necessary to determine the best treatment algorithm for these patients.CRS significantly impairs quality of life, and therapies are targeted toward improving patient symptoms, and hopefully in the future, treating the underlying immune dysfunction. Management of CRS and severe asthma requires a multidisciplinary approach. Further real-world studies are necessary to determine the best treatment algorithm for these patients.