In this research, polyester-based polymers/Fe3O4 nanocomposite foams were prepared in order to study their performance; namely shape recovery speed and actuation load. A foamed structure was obtained through a solid-state foaming process, which was studied and optimized in previous research. The optimum foaming parameters were applied in an attempt to achieve the highest foaming ratio possible. A Taguchi Map was then designed to determine the number of experiments to be conducted. The experimental results showed that the maximum actuation load obtained was 3.35 N, while optimal (fastest) recovery speed was 6.36 mm/min. Furthermore, temperature had no impact on the actuation load as long as a temperature above the Tg was applied. Moreover, the addition of nanoparticles reduced shape recovery speed due to discontinuity within the polymer matrix.The study's aim was a clinical observation concerning the influence of oral health on functional status in stroke patients undergoing neurorehabilitation. This pilot cross-sectional clinical study was performed in 60 subacute phase stroke patients during 12 weeks of treatment. The program was patient-specific and consisted of neurodevelopmental treatment by a comprehensive rehabilitation team. The functional assessment was performed using the Barthel index (BI), Berg balance scale (BBS), functional independence measure (FIM), and Addenbrooke's cognitive examination III (ACE III) scales. Oral health was assessed according to World Health Organization (WHO) criteria, and it was presented using DMFT, DMFS, gingival index (GI), and plaque index (PlI). Significant improvement in many functional scales was noticed. TD-139 mw However, important differences in most dental parameters without relevant changes in GI and PlI after the study were not observed. Reverse interdependence (p less then 0.05) was shown between physical functioning (BI, FIM, or BBS) with GI and PlI results, and most dental parameters correlated with ACE III. Using multivariate regression analysis, we showed that ACE III and BI are predictive variables for DMFT, just as FIM is for DS (p less then 0.05). The present research revealed that poor oral health status in patients after stroke might be associated with inpatient rehabilitation results.The identification of compounds which protect the double-membrane of mitochondrial organelles from disruption by toxic confomers of amyloid proteins may offer a therapeutic strategy to combat human neurodegenerative diseases. Here, we exploited an extract from the marine brown seaweed Padina pavonica (PPE) as a vital source of natural bioactive compounds to protect mitochondrial membranes against insult by oligomeric aggregates of the amyloidogenic proteins amyloid-β (Aβ), α-synuclein (α-syn) and tau, which are currently considered to be major targets for drug discovery in Alzheimer's disease (AD) and Parkinson's disease (PD). We show that PPE manifested a significant inhibitory effect against swelling of isolated mitochondria exposed to the amyloid oligomers, and attenuated the release of cytochrome c from the mitochondria. Using cardiolipin-enriched synthetic lipid membranes, we also show that dye leakage from fluorophore-loaded vesicles and formation of channel-like pores in planar bilayer membranes are largely prevented by incubating the oligomeric aggregates with PPE. Lastly, we demonstrate that PPE curtails the ability of Aβ42 and α-syn monomers to self-assemble into larger β-aggregate structures, as well as potently disrupts their respective amyloid fibrils. In conclusion, the mito-protective and anti-aggregator biological activities of Padina pavonica extract may be of therapeutic value in neurodegenerative proteinopathies, such as AD and PD.Fengyun-4A (FY-4A) is the first satellite of the Chinese second-generation geostationary orbit meteorological satellites (FY-4). The Advanced Geostationary Radiation Imager (AGRI), onboard FY-4A does not load with high-precision calibration facility in visible and near infrared (VNIR) channel. As a consequence, it is necessary to comprehensively evaluate its radiometric performance and quantitatively describe the attenuation while using its VNIR data. In this paper, the radiometric performance at VNIR channels of FY-4A/AGRI is evaluated based on Aqua/MODIS data using the deep convective cloud (DCC) target. In order to reduce the influence of view angle and spectral response difference, the bi-directional reflectance distribution function (BRDF) correction and spectral matching have been performed. The evaluation result shows the radiometric performance of FY-4A/AGRI (1) is less stable and with obvious fluctuations; (2) has a lower radiation level because of 24.99% lower compared with Aqua/MODIS; 3) has a high attenuation with 9.11% total attenuation over 2 years and 4.0% average annual attenuation rate. After the evaluation, relative radiometric normalization between AGRI and MODIS in VNIR channel is performed and the procedure is proved effective. This paper proposed a more reliable reference for the quantitative applications of FY-4A data.Given the current scarcity of curative treatment of COVID-19, the search for an effective treatment modality among all available medications has become a priority. This study aimed at investigating the role of functional inhibitors of acid sphingomyelinase (FIASMAs) on in-hospital COVID-19 mortality. In this retrospective cohort study, we included adult in-patients with laboratory-confirmed COVID-19 between 1 March 2020 and 31 August 2020 with definite outcomes (discharged hospital or deceased) from Erasme Hospital (Brussels, Belgium). We used univariate and multivariate logistic regression models to explore the risk factors associated with in-hospital mortality. We included 350 patients (205 males, 145 females) with a mean age of 63.24 years (SD = 17.4, range 21-96 years). Seventy-two patients died in the hospital and 278 were discharged. The four most common comorbidities were hypertension (184, 52.6%), chronic cardiac disease (110, 31.4%), obesity (96, 27.8%) and diabetes (95, 27.1%). Ninety-three participants (26.