The Chinese subset included 667 patients; of these, 363 (54%) received high-dose cisplatin. Baseline characteristics were comparable. While response rates were similar for NEPA and APR/GRAN during the acute, delayed and overall phases, significantly fewer NEPA patients experienced breakthrough CINV on individual Days 3-5 in both the Chinese patients and also in those receiving high-dose cisplatin. As a fixed oral NK1 RA/5HT3 RA combination given once/cycle, NEPA is a convenient highly effective prophylactic antiemetic that may offer better protection from CINV than a 3-day APR/GRAN regimen on Days 3-5 following highly emetogenic chemotherapy.Whether creativity is a domain-general or domain-specific ability has been a topic of intense speculation. Although previous studies have examined domain-specific mechanisms of creative performance, little is known about commonalities and distinctions in neural correlates across different domains. We applied activation likelihood estimation (ALE) meta-analysis to identify the brain activation of domain-mechanisms by synthesizing functional neuroimaging studies across three forms of artistic creativity music improvisation, drawing, and literary creativity. ALE meta-analysis yielded a domain-general pattern across three artistic forms, with overlapping clusters in the presupplementary motor area (pre-SMA), left dorsolateral prefrontal cortex, and right inferior frontal gyrus (IFG). Regarding domain-specificity, musical creativity was associated with recruitment of the SMA-proper, bilateral IFG, left precentral gyrus, and left middle frontal gyrus (MFG) compared to the other two artistic forms; drawing creativity recruited the left fusiform gyrus, left precuneus, right parahippocampal gyrus, and right MFG compared to musical creativity; and literary creativity recruited the left angular gyrus and right lingual gyrus compared to musical creativity. Contrasting drawing and literary creativity revealed no significant differences in neural activation, suggesting that these domains may rely on a common neurocognitive system. Overall, these findings reveal a central, domain-general system for artistic creativity, but with each domain relying to some degree on domain-specific neural circuits.Traumatic dental injuries (TDIs) occur most frequently in children and young adults. Older adults also suffer TDIs but at significantly lower rates than individuals in the younger cohorts. Luxation injuries are the most common TDIs in the primary dentition, whereas crown fractures are more commonly reported for the permanent teeth. Proper diagnosis, treatment planning and follow up are very important to assure a favorable outcome. These updates of the International Association of Dental Traumatology's (IADT) Guidelines include a comprehensive review of the current dental literature using EMBASE, MEDLINE, PUBMED, Scopus, and Cochrane Databases for Systematic Reviews searches from 1996 to 2019 and a search of the journal Dental Traumatology from 2000 to 2019. The goal of these guidelines is to provide information for the immediate or urgent care of TDIs. It is understood that some follow-up treatment may require secondary and tertiary interventions involving dental and medical specialists with experience in denomes.Paranasal sinuses (PNS) infections are common in children. They may cause common and well-known complications, but also, unusual and potentially devastating complications. Diagnosing PNS infections and complications in children requires knowledge of the unique anatomy of the nasal cavity and the PNS. In fetal life, nasal mucosa evaginations into the lateral nasal walls initiate the development of the PNS. The PNS continue to develop after birth and complete their maturation and pneumatization at different ages during childhood which makes the pattern of PNS infections determined by patient age. Complications are caused by direct spread of the infection to the orbit, face, intracranial or osseous structures or hematogenous spread of the infection to the intracranial structures. Emergent imaging studies are often necessary in the evaluation of the complications in pediatric patients when the symptoms persist for 10 days and/or if there is evidence of intracranial or orbital complications. In addition, immunocompromised children are especially vulnerable to developing unusual complications. Computed tomography (CT) is excellent for determining whether there is intraorbital extension of PNS disease. However, when the infection approaches the orbital apex, a magnetic resonance imaging (MRI) study with contrast is necessary to assess spread into the cavernous sinus and the intracranial compartment. The goal of this manuscript is to review and characterize imaging findings of PNS infections using CT and MRI allowing determination of the extent of PNS infections and their common and unusual complications in children. In addition, a summary of the development of the normal PNS is provided.Good sleep habits are important for emotional well-being. Studies have linked sleep with people's ability to regulate their emotions in response to stressful events, yet little is known specifically about how sleep is related to a person's ability to recover affectively from a stressful experience. The current study examined self-reported sleep habits and their associations with both positive and negative affective recovery from a laboratory-induced stressor. Participants (N=120) reported their sleep habits over the previous month and then engaged in a laboratory psychosocial stress task. Affect was measured before, during, and 6 minutes after the task. Different aspects of sleep were related to poorer positive and negative affective recovery. Worse sleep quality was associated with higher post-recovery negative affect, whereas worse sleep efficiency was associated with lower post-recovery positive affect. Findings suggest that poor sleep is associated with prolonged affective recovery from a stressful event. Implications for health and well-being are discussed. This article is protected by copyright. All rights reserved.Background In the Australian southeast, the saltmarsh mosquito Aedes vigilax (Skuse) is the focus of area-wide larviciding campaigns employing the biological agent Bacillus thuringiensis var. israelensis (Bti). Although generally effective, frequent inundating tides and considerable mangrove cover can make control challenging. Here, we describe the efficacy and persistence of an aqueous Bti suspension (potency 1200 International Toxic Units; strain AM65-52) within a mixed saltmarsh-mangrove system and the use of affordable unmanned aerial systems (UAS) to identify and map problematic levels of mangrove canopy cover. UNC3866 Results High mangrove canopy density (>40% cover) reduced product deposition by 75.2% (0.01 ± 0.002 μL/cm2 vs. 0.05 ± 0.006 μL/cm2 ), larval mortality by 27.7% (60.7 ± 4.1% vs. 84.0 ± 2.4%), and ground level Bti concentrations by 32.03% (1144 ± 462.6 vs. 1683 ± 447.8 spores ml-1 ) relative to open saltmarsh. Persistence of product post-application was found to be low (80.6% loss at 6 h) resulting in negligible additional losses to tidal inundation 24 h post-application.