Explantation and placement of an antibiotic spacer is a well-recognized treatment for periprosthetic infection after total knee replacement. Although static spacers may be occasionally indicated, many patients benefit from an articulating spacer that preserves the function and range of motion. However, many articulating spacer techniques provide an imbalanced cement-on-cement articulating knee that cannot tolerate full weight-bearing or provide adequate stability for daily function. A more durable articulating spacer may be ideal by permitting unrestricted weight-bearing, a functional range of motion, and potentially delayed reimplantation for medically complex patients. We present our evolved and reproducible technique for gap-balanced articulating spacers using cement augments and dowel stems. The result is a stable construct that permits full weight-bearing and a functional range of motion.Dual-mobility (DM) bearings in total hip arthroplasty (THA) have been reported to reduce dislocation rates, especially in high-risk patients, and are being rapidly adopted in primary and revision THAs. However, this technology introduces additional interfaces that have the potential to result in unforeseen complications. We present a series of 3 patients with mechanically assisted crevice corrosion at the acetabular component-metal dual-mobility liner interface. Consequently, we urge judicious use and close clinical observation of this new, effective technology in THA. Aseptic loosening has long been an associated etiology for revision total knee arthroplasty (TKA). This case series investigates commonalities between 9 patients who underwent revision TKA and were found to have complete debonding at the cement-implant interface of a femoral and/or tibial component within the past 2years. Only 3 preoperative radiographs were indicative of aseptic loosening, and all patients had an infectious etiology ruled out. This case series and other similar reports suggest that there may be a growing concern for debonding as a modern form of aseptic loosening. Further research through American Joint Replacement Registry and other national databases will need to be conducted to better understand if this is truly a new cause for concern after TKA and how it may be best prevented.This case series and other similar reports suggest that there may be a growing concern for debonding as a modern form of aseptic loosening. Further research through American Joint Replacement Registry and other national databases will need to be conducted to better understand if this is truly a new cause for concern after TKA and how it may be best prevented. A prosthetic joint infection (PJI) is one of the possible complications after total hip arthroplasty (THA). kira6 chemical structure Several studies, but not all, have reported smoking as a risk factor of PJIs in orthopaedic surgery. This study summarizes the most recent evidence using a systematic review of whether tobacco use (not only tobacco smoking) is a risk factor in developing PJIs, specifically after THA. Ovid Medline, EMBASE, Scopus, Web of Science, and Cochrane databases were searched from inception to July 2019 to identify case-control studies that examined the PJI risk in tobacco users and tobacco nonusers undergoing THA. Publication bias was also assessed through funnel plots. Searches identified 2689 articles, and 10 of these, involving a total of 20,640 patients, met the inclusion criteria. The overall odds ratio (pooled odds ratio) to develop either a superficial infection, a deep infection, or an infection requiring revision surgery for tobacco users vs nonusers was 1.54 (95% confidence interval 1.25-1.91) when a fixed-effect model was used and 1.56 (95% confidence interval 1.10-2.21) when a random-effect model was used. No publication bias was observed among the identified studies. The findings of the study indicated that tobacco use is associated with a higher risk of PJIs in patients undergoing THA.The findings of the study indicated that tobacco use is associated with a higher risk of PJIs in patients undergoing THA. Irrigation and debridement is an attractive treatment option for acute perioperative and acute hematogenous periprosthetic hip infections. We ask the following questions (1) What are the results of a two-stage reimplantation if preceded by debridement, antibiotics, and implant retention (DAIR) compared with two-stage reimplantation without an antecedent DAIR? and (2) Do McPherson Musculoskeletal Infection Society (MSIS) host criteria influence results? A total of 114 patients were treated with two-stage exchange for periprosthetic hip infection. Sixty-five patients were treated initially with a two-stage exchange, whereas 49 patients underwent an antecedent DAIR before a two-stage exchange. Patients were classified based on MSIS host criteria. Demographics demonstrated homogeneity between cohorts. Failure was defined as return to the operating room for infection, draining sinus, or systemic infection. Treatment failure occurred in 42.9% (21 of 49) of patients treated with an antecedent DAIR. In contrastmise the results of future two-stage procedures.In the present work, applying the whole-cell patch-clamp technique in voltage clamp mode, we have investigated the effects of different drugs, such as riluzole, Psora-4 and Tram-34, on the potassium currents in four human lymphoma cell lines. We focused on outward currents mediated by two potassium channels (Kv1.3 and KCa3.1), which are known to play a key physiological role in lymphoid cells. The currents were evoked by voltage ramps ranging from -120 mV to +40 mV and the conductance of the two potassium channels was measured between +20 mV and +40 mV, both in the absence and in the presence of the specific blockers Psora-4 (Kv1.3; 1 µM) and Tram-34 (KCa3.1; 1 µM). The effect of the latter was tested after KCa3.1 channels were activated by riluzole 10 µM. Taken together, these data could be useful as an indication of the functional characteristics of the potassium channels in human lymphomas and represent a starting point for the study of potassium conductance in cellular models of these tumors.