Synthetic gels with switchable interfacial properties have great potential in smart devices and controllable transport. Herein, we design an organogel by incorporating a binary liquid mixture with an upper critical solution temperature (UCST) into a polymer network, resulting in reversible modulation of lubrication and adhesion properties. As the temperature changes, the lubricating mechanism changes reversibly from boundary lubrication to hydrodynamic lubrication due to the phase separation within the binary solution permeating the gel (friction coefficient from 0.4 to 0.03). Droplets appear on the gel surface at low temperature and disappear when the temperature is higher than the critical phase separation temperature (T ps ) of organogel. This organogel possesses a relatively low ice adhesive strength (less than 1 kPa). This material has potential applications in anti-icing and smart devices, and we believe that this design strategy can be expanded to other systems such as aqueous solution and hydrogels. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.INTRODUCTION Metabolomics provide a promising tool to understand the pathogenesis and to identify novel biomarkers of dementia. This study aimed to determine circulating metabolites associated with incident dementia in a Chinese cohort, and whether a selected metabolite panel could predict dementia. METHODS Thirty-eight metabolites in baseline serum were profiled by nuclear magnetic resonance in 1440 dementia-free participants followed 5 years in the Shanghai Aging Study. RESULTS Higher serum levels of glutamine and O-acetyl-glycoproteins were associated with increased risk of dementia, whereas glutamate, tyrosine, acetate, glycine, and phenylalanine were negatively related to incident dementia. A panel of five metabolites selected by least absolute shrinkage and selection operator within cross-validation regression analysis could predict incident dementia with an area under the receiver-operating characteristic curve of 0.72. DISCUSSION We identified seven candidate serum metabolic biomarkers for dementia. These findings and the underlying biological mechanisms need to be further replicated and elucidated in future studies. © 2020 the Alzheimer's Association.Flowers, the reproductive organs of angiosperms, show a high degree of diversity in morphological structure and flowering habits to ensure pollination and fertilization of plants. Effect of flower movement on pollination and fertilization was investigated in Ipomoea purpurea (Convolvulaceae) in this study. Fluorescence microscope was used to observe the germination of pollen grains at different temperatures. From 400 am to 600 am, the stigma was taller than the filaments so that self-pollination had no chance to be completed and cross-pollination was carried out by insects. Pollen grains germinated rapidly after falling on the stigma, the pollen tube reached the ovule to complete the fertilization after 2-3 h. From 700 am to 900 am, filaments of two stamens grew rapidly and reached the same height as the stigma to allow self-crossing. But at this time, the natural temperature was already high and not conducive to the germination of pollen grains. The corolla formed a closed inverted bell-shaped corolla, where the inner microenvironment ensured the completion of pollen germination and fertilization. Preferential cross-pollination and delayed self-crossing of I. purpurea provided a doubly guaranteed mechanism for pollination and fertilization, allowing its adaptation to high temperature climate. This article is protected by copyright. All rights reserved.The high morbidity and mortality of cancer urge for innovative therapeutics. Very recently, several old drugs approved by US Food and Drug Administration (FDA) or undergoing clinical trials, such as 2-deoxy-D-glucose, disulfiram, artemisinin, chloroquine, metformin and aspirin, which have been extensively applied clinically for the treatments of other diseases with reliable evidences of biosafety, have been engineered into nanosystems for enhancing cancer therapy. These old drugs can cooperate with other components of nanosystems or the ambient biological environments, to favor tumor-specific therapeutics by nontoxicity-to-toxicity transition. This minireview provides a concentrated summary of the most recent progresses made in this emerging field, highlighting the "old drugs, new uses" strategy for favoring the construction of next-generation nanomedicines. Selleckchem EN4 It is expected that the clinical translation of nanomedicines can be accelerated by repurposing old drugs to elevate cancer therapeutic efficacy and specificity. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.The Intramolecular benzyne-phenolate [4+2] cycloaddition has been developed. Benzyne precursors, having vicinal halogen-sulfonate functionalities, linked with a phenol(ate) by various tether groups undergo efficient intramolecular [4+2] cycloaddition by treatment of Ph3MgLi or  nBuLi for halogen-metal exchange to form various benzobarrelenes. The method is characterized by wide availability of reaction precursors and high yield for the products. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Since December 2019, a number of patients with novel coronavirus pneumonia (NCP) have been identified in Wuhan, Hubei Province, China. NCP has rapidly spread to other provinces and cities in China and other countries in the world. Due to the rapid increase in reported cases in China and around the world, on January 30, 2020, the World Health Organization (WHO) Emergency Committee announced that NCP is a Public Health Emergency of International Concern (PHEIC). However, there are relatively few suggestions and measures for tumor patients, especially patients with head and neck tumors. This article summarizes the prevention and control of disease in our medical institution to provide a reference for front-line head and neck surgeons. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.Facial rejuvenation with injectable filler substances is a frequently applied outpatient procedure. However, light, moderate, and even severe complications may occur. A case of tissue necrosis at the upper lip after injection of highly cross-linked hyaluronic acid together with the following salvage procedure is presented here. We discuss this complication with respect to relevant anatomy and physicochemical properties of the filler substance and review the recommendations given in literature for decreasing the likelihood of such an adverse event. © 2020 Wiley Periodicals, Inc.