A conformational B-cell epitope is one of the main components of vaccine design. It contains separate segments in its sequence, which are spatially close in the antigen chain. The availability of Ag-Ab complex data on the Protein Data Bank allows for the development predictive methods. Several epitope prediction models also have been developed, including learning-based methods. However, the performance of the model is still not optimum. The main problem in learning-based prediction models is class imbalance. This study proposes CluSMOTE, which is a combination of a cluster-based undersampling method and Synthetic Minority Oversampling Technique. The approach is used to generate other sample data to ensure that the dataset of the conformational epitope is balanced. The Hierarchical DBSCAN algorithm is performed to identify the cluster in the majority class. Some of the randomly selected data is taken from each cluster, considering the oversampling degree, and combined with the minority class data. The balae glycoprotein antigen.The experimental result shows that CluSMOTE Decision Tree outperformed the Support Vector Machine in terms of AUC and Gmean as performance measurements. The mean AUC of CluSMOTE Decision Tree in the Kringelum and the SEPPA 3 test sets are 0.83 and 0.766, respectively. This shows that CluSMOTE Decision Tree is better than other methods in the general protein antigen, though comparable with SEPPA 3 in the glycoprotein antigen.Adversarial Optimization provides a reliable, practical way to match two implicitly defined distributions, one of which is typically represented by a sample of real data, and the other is represented by a parameterized generator. (R)-2-Hydroxyglutarate mouse Matching of the distributions is achieved by minimizing a divergence between these distribution, and estimation of the divergence involves a secondary optimization task, which, typically, requires training a model to discriminate between these distributions. The choice of the model has its trade-off high-capacity models provide good estimations of the divergence, but, generally, require large sample sizes to be properly trained. In contrast, low-capacity models tend to require fewer samples for training; however, they might provide biased estimations. Computational costs of Adversarial Optimization becomes significant when sampling from the generator is expensive. One of the practical examples of such settings is fine-tuning parameters of complex computer simulations. In this work, wed to any stochastic simulation.In recent years, a large body of literature has accumulated around the topic of research paper recommender systems. However, since most studies have focused on the variable of accuracy, they have overlooked the serendipity of recommendations, which is an important determinant of user satisfaction. Serendipity is concerned with the relevance and unexpectedness of recommendations, and so serendipitous items are considered those which positively surprise users. The purpose of this article was to examine two key research questions firstly, whether a user's Tweets can assist in generating more serendipitous recommendations; and secondly, whether the diversification of a list of recommended items further improves serendipity. To investigate these issues, an online experiment was conducted in the domain of computer science with 22 subjects. As an evaluation metric, we use the serendipity score (SRDP), in which the unexpectedness of recommendations is inferred by using a primitive recommendation strategy. The results indicate that a user's Tweets do not improve serendipity, but they can reflect recent research interests and are typically heterogeneous. Contrastingly, diversification was found to lead to a greater number of serendipitous research paper recommendations.When real-time systems are modeled as timed automata, different time scales may lead to substantial fragmentation of the symbolic state space. Exact acceleration solves the fragmentation problem without changing system reachability. The relatively mature technology of exact acceleration has been used with an appended cycle or a parking cycle, which can be applied to the calculation of a single acceleratable cycle model. Using these two technologies to develop a complex real-time model requires additional states and consumes a large amount of time cost, thereby influencing acceleration efficiency. In this paper, a complex real-time exact acceleration method based on an overlapping cycle is proposed, which is an application scenario extension of the parking-cycle technique. By comprehensively analyzing the accelerating impacts of multiple acceleratable cycles, it is only necessary to add a single overlapping period with a fixed length without relying on the windows of acceleratable cycles. Experimental results show that the proposed timed automaton model is simple and effectively decreases the time costs of exact acceleration. For the complex real-time system model, the method based on an overlapping cycle can accelerate the large scale and concurrent states which cannot be solved by the original exact acceleration theory.We introduce SANgo (Storage Area Network in the Go language)-a Go-based package for simulating the behavior of modern storage infrastructure. The software is based on the discrete-event modeling paradigm and captures the structure and dynamics of high-level storage system building blocks. The flexible structure of the package allows us to create a model of a real storage system with a configurable number of components. The granularity of the simulated system can be defined depending on the replicated patterns of actual system behavior. Accurate replication enables us to reach the primary goal of our simulator-to explore the stability boundaries of real storage systems. To meet this goal, SANgo offers a variety of interfaces for easy monitoring and tuning of the simulated model. These interfaces allow us to track the number of metrics of such components as storage controllers, network connections, and hard-drives. Other interfaces allow altering the parameter values of the simulated system effectively in real-time, thus providing the possibility for training a realistic digital twin using, for example, the reinforcement learning (RL) approach.