6%, UR 56.8%, BPS/IC 63.15%, FI 87.5% and DI 66.7%. Clinical and/or statistically significant improvements in all efficacy variables studied were observed. The loss of therapeutic effect at 75 months follow-up was 34%. Device-related pain appeared in 25 patients (39%), 20 resolved by reprogramming and 5 required device removal. An overall improvement in QoL and high levels of satisfaction with the procedure were observed. More than 90% of patients would recommend SNS to a friend or relative. SNS is a minimally invasive procedure that offers a real alternative to patients with refractory pelvic floor dysfunctions. Its safety profile is very favourable and provides a long-lasting improvement in symptoms and QoL.SNS is a minimally invasive procedure that offers a real alternative to patients with refractory pelvic floor dysfunctions. Its safety profile is very favourable and provides a long-lasting improvement in symptoms and QoL.The authors wish to make the following corrections to this paper [...].The authors regret to have made a mistake in publishing this paper [...].Forest fires are undesirable situations with tremendous impacts on wildlife and people's lives. Reaching them quickly is essential to slowing down their expansion and putting them out in an effective manner. This work proposes an optimized distribution of fire stations in the province of Valencia (Spain) to minimize the impacts of forest fires. Using historical data about fires in the Valencia province, together with the location information about existing fire stations and municipalities, two different clustering techniques have been applied. Floyd-Warshall dynamic programming algorithm has been used to estimate the average times to reach fires among municipalities and fire stations in order to quantify the impacts of station relocation. The minimization was done approximately through k-means clustering. The outcomes with different numbers of clusters determined a predicted tradeoff between reducing the time and the cost of more stations. The results show that the proposed relocation of fire stations generally ensures faster arrival to the municipalities compared to the current disposition of fire stations. In addition, deployment costs associated with station relocation are also of paramount importance, so this factor was also taken into account in the proposed approach.Obesity and diet are associated with colorectal cancer (CRC) risk, and microbiome could mediate this risk factor. To investigate this interaction, we performed a case-control study (34 CRC cases and 32 controls) and analyzed fecal microbiota composition using 16S rRNA metabarcoding and sub-sequential shotgun analyses of genomic bacterial DNA to evaluate the role of microbiome and diet in CRC etiology, taking into account vitamin D and other risk biomarkers. Dietary habits were evaluated using a short questionnaire. Multivariate methods for data integration and mediation analysis models were used to investigate causal relationships. CRC cases were significantly more often deficient in vitamin D than controls (p = 0.04); FokI and CYP24A1 polymorphism frequency were different between cases and controls (p = 0.03 and p = 0.02, respectively). A diet poor in fatty fish and rich in carbohydrates was found to be significantly associated with CRC risk (p = 0.011). The mediation analysis confirmed the significant role of the microbiome in mediating CRC risk-increasing levels of Bifidobacteria/Escherichia genera ratio, an indicator of "healthy" intestinal microbiome, can overcome the effect of diet on CRC risk (p = 0.03). This study suggests that microbiome mediates the diet effect on CRC risk, and that vitamin D, markers of inflammation, and adipokines are other factors to consider in order to achieve a better knowledge of the whole carcinogenic process.Antibody drugs with a high affinity and specificity are effective and safe for intractable diseases, such as cancers and autoimmune diseases. Furthermore, they have played a central role in drug discovery, currently accounting for eight of the top 20 pharmaceutical products worldwide by sales. Forty years ago, clinical trials on antibody drugs that were thought to be a magic bullet failed, partly due to the immunogenicity of monoclonal antibodies produced in mice. The recent breakthrough in antibody drugs is largely because of the contribution of phage display technology. Here, we reviewed the importance of phage display technology as a powerful platform for antibody drug discovery from various perspectives, such as the development of human monoclonal antibodies, affinity enhancement of monoclonal antibodies, and the identification of therapeutic targets for antibody drugs.Uterine myomas or fibroids are the most common benign female tumors of the reproductive organs, associated with significant morbidity and quality of life impairment. selleck Several epidemiological risk factors for their occurrence have been identified so far, including nutrition and dietary habits. In this investigation, authors reviewed, as a narrative review, the data about diet and uterine myoma development in order to homogenize the current data. A PubMed search was conducted for the years 1990-2020, using a combination of keywords of interest for the selected topic. The authors searched the databases, selecting the randomized clinical studies, the observational studies, and the basic (experimental), clinical, and epidemiological researches. Once they collected the articles, they analyzed them according to the number of citations of each article, starting from the most cited to the least cited articles. Subsequently, authors collected the data of each article and inserted them in the various research paragraphs, summarizing the data collected. In this way, they crossed the available data regarding the association between nutrition habits and dietary components and myoma onset and growth. Many nutrients and dietary habits are associated with myoma development risk. These factors include low intakes of fruit, vegetables, and vitamin D, as well as pollutants in food. Despite the available data on the influence of some foods on the development of fibroids, further research is mandatory to understand all the nutrition risk factors which contribute to myoma growth and how exactly these risk factors influence myoma pathogenesis.