Moreover, gender differences in task persistence emerged, indicating that although interest and perceived competence motivated all students to exhibit persistence, girls were still more likely to demonstrate task persistence than boys. Overall, findings suggest that task persistence in elementary school is a complex behavior that requires both cognitive control skills to support engagement and the motivation to continue engaging as task difficulty increases.To make sense of others' actions, we generally consider what information is available to them. This information may come from different sources, including perception and inference. Like adults, young infants track what information agents can obtain through perception If an agent directly observes an event, for example, young infants expect the agent to have information about it. However, no investigation has yet examined whether young infants also track what information agents can obtain through inference, by bringing to bear relevant general knowledge. Building on the finding that by 4 months of age most infants have acquired the physical rule that wide objects can fit into wide containers but not narrow containers, we asked whether 5-month-olds would expect an agent who was searching for a wide toy hidden in her absence to reach for a wide box as opposed to a narrow box. Infants looked significantly longer when the agent selected the narrow box, suggesting that they expected her (a) to share the physical knowledge that wide objects can fit only into wide containers and (b) to infer that the wide toy must be hidden in the wide box. Three additional conditions supported this interpretation. Together, these results cast doubt on two-system accounts of early psychological reasoning, which claim that infants' early-developing system is too inflexible and encapsulated to integrate inputs from other cognitive processes, such as physical reasoning. Instead, the results support one-system accounts and provide new evidence that young infants' burgeoning psychological-reasoning system is qualitatively similar to that of older children and adults.Mediated priming refers to the activation of a target word by a prime word through an intermediate word. This type of priming provides behavioral evidence of between- and within-level spreading activation in the lexical system. Studies of toddlers show phonosemantic between-level mediated priming that supports a cascade of activation between different levels of processing. However, it is not clear whether the activation can spread freely within the same level. This study explored whether 24-month-old toddlers show mediated priming effects at the semantic level (e.g., cat [prime] - mouse [mediator] - cheese [target]) with a preferential looking task using an eye tracker. The results show a smaller proportion of target looking and greater pupil size in the related condition than in the unrelated condition; these effects were greater in the second half of the analysis window. We interpret these data as a spreading activation that is partially free but modulated during infancy. We also provide evidence of pupil dilation as a neurophysiological marker in a preferential looking task with priming. We discuss the results in light of the cognitive control, inhibition, and general cognitive skills of toddlers. A 1998 seminal study catapulted adverse childhood experiences (ACEs) into the zeitgeist and shaped assessment of these experiences and long-term health consequences via The ACEs Study Questionnaire (ACE-SQ). However, the ACE-SQ's childhood sexual abuse (CSA) item requires the perpetrator have been 5-years or older than the survivor for endorsement. This may not adequately capture CSA and limit the questionnaire's ability to detect survivors. This study assessed whether CSA survivors were missed by this 5-year modifier, whether service access was restricted, and whether those missed were at elevated risk for adverse outcomes. A sample of 974 women (M = 30.46) completed an online survey. Histories of CSA were assessed using the original ACE-SQ and an alternative version without the 5-year modifier. Participants were grouped by endorsement (Modifier, No Modifier, No CSA) and compared across numerous physical and mental health outcomes using MANOVA, ANOVA, and logistic regression. Numerous CSA survivors are presently missed by the 5-year modifier (n = 118 of N = 249). This group demonstrated the same elevated depression (t = 3.44, p = .002, d = 0.34), heightened somatic symptom burden (t = 3.34, p = .003, d = 0.35), and poorer subjective health (t = -2.86, p = .012, d = 0.27) as those captured by the modifier. Recommendations for research, practice, and policy include removing the 5-year modifier from CSA assessment, creating an empirically informed CSA definition, and eliminating or adjusting requisite cut-scores for accessing services.Recommendations for research, practice, and policy include removing the 5-year modifier from CSA assessment, creating an empirically informed CSA definition, and eliminating or adjusting requisite cut-scores for accessing services.Chimeric antigen receptor T cell (CAR-T) therapy has so far proved itself as a reliable therapeutic option for the treatment of relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL), diffuse large B-cell lymphoma (DLBCL), multiple myeloma (MM), and mantle cell lymphoma (MCL). However, this picture is not as colorful when it comes to the treatment of solid tumors mainly due to the lack of definitive tumor antigens, as well as the immunosuppressive tumor microenvironments and poor CAR-T infiltration. find more The recent developments in bioinformatics and cell biology, such as single-cell RNA sequencing, have offered silver linings in the subject of tumor antigen discovery. In the current review, we summarize the development of some CAR-T therapies that target novel tumor antigens, rather than the traditionally CAR-T-targeted ones, and briefly discuss the clinical antitumor achievements of those evaluated in patients, so far. Furthermore, we propose some tumor antigens that might someday be therapeutically beneficial while targeted by CAR-Ts based on the experimental evaluations of their specific monoclonal antibodies.