Empirical evaluation of CB513, CASP11, and CASP12 data sets indicates that our unsupervised enhancing scheme indeed generates more informative PSSM features for structure property prediction. Multiple trials have shown the efficacy and safety of endovascular therapy (EVT) of acute ischemic stroke in adults. Trials in children are lacking and only case reports and case series exist. However, the long-term outcome of children with acute ischemic stroke can be devastating with significant mortality and morbidity. CNQX cell line In this study, we describe the safety and efficacy of EVT in children with anterior circulation acute ischemic stroke who were included in the MR CLEAN Registry (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands). Patients under the age of 18 years who were treated with EVT for acute ischemic stroke between March 2014 and July 2017 were retrospectively reviewed up to 6 months after EVT. Nine children, aged 13 months to 16 years (median 14 years, interquartile range, 3-15 years), underwent EVT. Stroke cause was thromboembolism in children with end-stage heart failure on left ventricular assist device (4 of these 9 cases). Median tn risks and benefits of this treatment.EVT of children with acute ischemic stroke seems safe and feasible. However, these findings should be interpreted with caution as more and larger studies are needed to clarify the trade-off between risks and benefits of this treatment.The author explores the idea of sovereignty as an illusion that is and will continue to have deleterious effects on cooperative efforts to slow or stop climate change and the extinction of millions of species. To make this case, the notion of sovereignty is defined and its attributes described. This lays the foundation for arguing, from a psychoanalytic perspective, that sovereignty is a tightly held illusion (and practice). The last section of the article identifies the negative present and future impact of sovereignty with regard to the Anthropocene Age, as well as briefly identifying other possibilities for ordering societies.The author describes the evolution of theory and practice at the New York Psychoanalytic Society and Institute. The core concepts at the Institute have included the importance of unconscious fantasy, conflict and compromise theory, transference and countertransference, and defense analysis. In recent years, a variety of contemporary analytic theories have been incorporated into the theory and practice of the Institute. The importance of systematized research to theory development and practice is stressed.The authors share their observations on the implications of concepts originated in object relations theory in art therapy students' and clinicians' identity development. Through the lens of object relations theory, students considered how the personal informs the professional, as reflected in assemblage and artwork inspired by personal or found objects. Through their own creative expression, students learned how to apply object relations theory beyond its original formulation, and how their artwork acts as a transitional object between their personal history and professional individuation. The authors explore how creative expression may serve as a bridge between these two aspects of the self, thus facilitating an educated and creatively informed personal/professional integration in the process of clinical training and practice.In psychoanalytic discourse, the question of meaning or lack thereof should be relegated only to the domain of the interlocutor's perception. Not every slip of the tongue or bungled action is necessarily precipitated by some unconscious motivation, although one may construct meaning for it après coup (Nachträglichkeit). What is a message versus a noise depends on the perceptual experience of the analytic couple, and a cigar, if not just a cigar, depends on the context-specific fantasy of the perceiver. The author's aim is to show the difficulty of distinguishing the noise from the message in the interactive matrix of the analytic situation. Yet what at first may seem to be a banal error such as double-booking may at times enliven a stultified course of the analytic process; it may even drag a stillborn transference out of its embalmed closet.The author explores the idea that psychoanalysis is a process that facilitates, for some patients, the emergence of an ungovernable self. To make this case, Agamben's notion of the ungovernable self and its relation to potentiality-actuality, excess, and inoperativity are explained in light of psychosocial development. It is argued that the seeds of the ungovernable self lie within the parent-infant space of speaking and acting together, wherein good-enough parents' personalizing attunements to infants' assertions facilitate children's sense of singularity that is not contingent on social-political apparatuses. This space of suchness provides a secure base for children's transition to political spaces. From here, the argument shifts to the psychoanalytic process, which (1) affirms the singularity of the individual while engaging in inquiry into and exploration of the patient's life; (2) possesses a key premise of the excess of the "unconscious"; and (3) fosters the exercise of ungovernable selves. Restriction spectrum imaging-magnetic resonance imaging is a short duration enhanced diffusion-weighted technique that seeks to standardize sequences and predict upgrading. We test this technology for active surveillance biopsies. Our objective is to investigate the utility of restriction spectrum imaging-magnetic resonance imaging to improve upgrading detection in a prostate cancer active surveillance cohort. We prospectively enrolled men on active surveillance undergoing repeat biopsy from January 2016 to June 2019. Subjects underwent prostate multiparametric magnetic resonance imaging and restriction spectrum imaging-magnetic resonance imaging reviewed by a urological radiologist for PI-RADS® scored lesions, followed by magnetic resonance imaging-guided prostate biopsy by a urologist. Restriction spectrum imaging-magnetic resonance imaging analysis with proprietary research software (CorTechs Labs, San Diego, California) generated a restricted signal map. We compared the restricted signal map and apparent diffusion coefficient values using T-test, ANOVA, and logistic regression analyses for prediction of upgrading.