This meta-analysis demonstrated that 447X carriers and H allele in LPL gene associated with low risk of T2DM, which may due to in part to the change of serum level of TC, TG, LDL, and HDL.The clinical outcome of papillary thyroid carcinoma (PTC) patients with an indeterminate response after initial therapy is reported to be intermediate, between incomplete and excellent responses. This study evaluated the outcomes of PTC patients with indeterminate response after initial therapy. It was further determined whether the indeterminate findings predicted outcomes more precisely. Patients were further classified into 3 groups based on risk of structural persistence/recurrence Tg group detectable thyroglobulin, negative antithyroglobulin antibody, regardless nonspecific imaging findings; TgAb group positive antithyroglobulin antibody, regardless thyroglobulin levels and nonspecific imaging findings, and Image group nonspecific findings on neck ultrasonography or faint uptake in the thyroid bed on whole-body scan, undetectable thyroglobulin and negative antithyroglobulin antibody. Sixty-six patients aged 44.1±12.7 years were studied, of whom 58 (87.9%) were females. All patients underwent total thyroidectomy, and 52 patients (78.8%) received radioiodine. After 5.7 years (P25-75 2.6-9.75 years) of follow-up, most patients (89.4%) were reclassified as having an excellent response or remained in the indeterminate response to therapy. Structural recurrence/persistence disease was detected in 7 (10.6%) patients. The persistence/recurrence rate in groups were as follow Tg, 2.63%; TgAb, 31.25%; Image, 8.3% (p=0.007). The 10-years disease-free survival rate in the TgAb group was significantly reduced (p=0.022). Our results suggest that patients with PTC and indeterminate response due to positive serum antithyroglobulin antibody have more risk of development of structural disease. These findings suggest a more individualized follow-up strategy for patients with an indeterminate response.Idiopathic hypoparathyroidism leads to hypocalcemia and hyperphosphatasemia and usually has a genetic aetiology. The variable but often subtle signs and symptoms usually lead to a misdiagnosis of hypoparathyroidism. Case records of 32 patients of idiopathic hypoparathyroidism admitted over a period of five years were analysed. There was a lag period of 5.94 years from the onset of symptoms to the diagnosis. Carpopedal spasm was the most common indication for admission to the hospital. Trivial symptoms such as fatigue (84%) and paresthesia (62.5%) were the most common reported symptoms. A sum of 46.5% of the patients were on antiepileptic drugs before the correct diagnosis of hypoparathyroidism was made. This observation emphasized that Calcium profile should be obtained in patients with history of paresthesia and seizure to avoid the long delay in diagnosis of hypoparathyroidism. To investigate the feasibility and effectiveness of a low-threshold disease prevention offer in a pilot project for employees Methodology Employees of a company working in office or on production (n=144; 90 women, 54 men) with an average age of 39.25 (StA 11.5) years were interviewed and clinically examined using a questionnaire on habits and knowledge in the prevention of dental diseases. The oral hygiene indices Papillae Bleeding Index (PBI) and the modified Approximal Plaque Index (mAPI) as well as exploratory depth measurements (STM) were collected. Subsequently, a training in dental disease prevention was carried out with a specially produced video as well as the provision of sugar-free chewing gum and mouthwash solutions for twice daily use for a period of one year. After one year, the questionnaire was again issued and the clinical parameters were collected. The study was approved by the UW/H Ethics Committee. Statistical analysis was carried out with SPSS 26. 85 patients with an average age of 39.23 (StD 11.3) years could be examined after one year (59 women, 26 men). The analysis of the questionnaire showed a significant improvement in oral health behavior. The corresponding total score improved from 10.68 (1.93) to 9.97 (1.60) (p<0.05). The PBI improved from 0.43 (0.40) to 0.31 (0.36) (p<0.05), the mAPI from 1.54 (0.51) to 1.35 (0.39) (p<0.01). The STM was reduced from 1.83 (0.39) to 1.56 (0.36) (p<0.001). The dental disease prevention program for employees appears suitable for implementation at workplace and has shown significant improvements in oral health behavior as well as in clinical parameters.The dental disease prevention program for employees appears suitable for implementation at workplace and has shown significant improvements in oral health behavior as well as in clinical parameters.Surgical treatment pathways can favor the development of Adverse Events (AE) due to the inherent complexity of their service delivery. The World Health Organization (WHO) Surgical Safety Checklist (SSC) is an instrument that effectively reduces perioperative morbidity and mortality. Against this background, in 2016 the Federal Joint Committee (G-BA) issued a Quality Management Directive (QM-RL) making the use of checklists mandatory for surgical procedures. The aim of this study was to compare the checklist compliance of all ten surgical organizational units of the University Medical Center Mainz in the second half of 2017 and 2018. In addition to the annex of the SSC, the processing of the subitems »Sign-In«, »Team-Time-Out« and »Sign-Out« was evaluated. A comparison of 2017 with 2018 showed an increase in all parameters (»Creation of checklist« (94.2 / 96.5%), »Sign-In« (81.4 / 84.4%), »Team-Time-Out« (56.8 / 62.4%) and »Sign-Out« (50.7 / 57.9%), without, however, statistical significance (p>0.05). In contrast, there were significant differences between certified and non-certified surgical operating units. check details The parameters showing significant differences were found to be »Sign-In« (87.9 / 71.8%; p=0.034), »Team-Time-Out« (68.4 / 39.4%; p=0.029) and »Sign-Out« (62.1 / 33.6%; p=0.029) for 2017 and »Team-Time-Out« (76.2 / 41.7%); p=0.019) and the »Sign-Out« (71.3 / 37.9%; p=0.019) for 2018. From 2017 to 2018, there was increased implementation of the SCC, particularly in certified facilities. Therefore, the external control of prescribed quality features, for instance, as part of a certification procedure, appears to be a suitable tool for increasing checklist compliance.