During the course of therapy, 10 dressing changes were performed 3 to 5 days apart. After 31 days of therapy, healthy granulation tissue with minimal exudate was noted. Complete wound closure was achieved after 5 months of treatment. Negative pressure wound therapy with instillation and dwell time can enhance the healing potential of a complex surgical wound after spinal fusion.Negative pressure wound therapy with instillation and dwell time can enhance the healing potential of a complex surgical wound after spinal fusion. Thoracic aortic graft infection is a rare complication after cardiac surgery with no consensus having been reached on the most appropriate type of management. Although most commonly caused by gram-positive cocci, aortic graft infection by Mycoplasma hominis can occur. A 63-year-old male patient with an aneurysm of the ascending aorta was admitted to the authors' institution for surgical treatment. A replacement of the ascending aorta with a polyester vascular graft was performed using a valve-sparing aortic valve reimplantation technique. During postoperative course, the patient became septic with a spiking fever and elevated inflammatory markers. A computed tomography scan revealed signs of mediastinitis. M hominis was identified in blood cultures and intraoperative tissue samples. An antibiogram-based antibiotic solution (tigecycline in 5% glucose solution) was instilled twice daily into the thoracic cavity using negative pressure wound therapy with instillation and dwell time for 8 days. This type of management allowed the authors to avoid graft replacement, and good midterm outcomes were achieved. To the authors' best knowledge, this is the first described successful treatment of an aortic graft infection caused by M hominis without a surgical removal of the prosthetic material using antibiotic irrigation.To the authors' best knowledge, this is the first described successful treatment of an aortic graft infection caused by M hominis without a surgical removal of the prosthetic material using antibiotic irrigation. Open abdominal wounds with intestinal fistula formation are challenging complications in abdominal surgery. Special fistula devices (SFD) used along with negative pressure wound therapy with instillation and dwell time (NPWTi-d), may improve management of these wounds, increasing NPWT dressing durability and helping decrease dressing leakage. A 57-year-old, obese (body mass index 55 kg/m²) female with a long history of Crohn disease and multiple intestinal resections, presented with an incarcerated parastomal hernia, abscess formation, and septic shock. After the hernia was repositioned and the infection controlled, a bovine mesh-augmented hernia repair was performed. Skin rotation flaps for wound closure became necrotic and led to an infected, open abdominal wound measuring about 60 cm x 50 cm with formation of 2 additional small bowel fistulas alongside the ostomy and a massive bacterial and fungal superinfection. After surgical debridement, NPWTi-d with 10 minutes soaking time with isotonic saline soluwith SFDs represents a viable tool for the management of challenging fistulizing abdominal wounds. Pyoderma gangrenosum (PG) is a rare, ulcerative dermatosis that is part of a systemic auto-inflammatory process. see more The overall incidence of PG is 5.8 per 100 000 individuals and it is associated with an increased mortality rate compared with the general population. Due to the pathergy phenomenon-present in 20% to 30% of cases-traumatic events, such as debridement or surgery, are often avoided in these patients. This report is on the use of negative pressure wound therapy with instillation and dwell time (NPWTi-d) combined with a reticulated open cell foam dressing with through holes (ROCF-CC) to achieve debridement and granulation in a lower extremity PG wound. A known patient with history of neuropathic arthritis, systemic lupus erythematosus, and cryoglobulinemic vasculitis presented with worsening of his lower extremity wound including new onset pain, odor, and purulent discharge. Negative pressure wound therapy with instillation and dwell time using a hypochlorous acid solution and a ROCF-CC was initiated. Significant decrease in necrotic tissue was noted by day 4, with improved granulation tissue growth by day 25. No pathergy occurred in this case. The use of NPWTi-d with ROCF-CC demonstrated positive debridement effects on this PG wound.The use of NPWTi-d with ROCF-CC demonstrated positive debridement effects on this PG wound. This retrospective observational study analyzes the bacteriological profile of pathogens causing burn wound infections in a tertiary care center. This study was conducted at Father Muller Medical College Hospital, Karnataka, India, from January 2014 through December 2016. The specimens (ie, pus or a wound swab) were collected from patients with suspected of infection and processed as per standard microbiological techniques. The antibiotic sensitivity testing was performed by the Kirby Bauer's disk diffusion test on Mueller-Hinton agar as per Clinical and Laboratory Standards Institute guidelines. During the study period, a total of 124 eligible patient samples were collected; 22 samples were excluded as there was no significant growth/colonization. Among the 102 patients included in the study, 56 (54.9%) were females and the majority (33, 32.35%) of the patients were between 18 to 30 years. Acinetobacter species and Pseudomonas aeruginosa (26.56% each) were the most common pathogen among gram-negative bacteria and Staphylococcus aureus (36, 11.25%) was the most common gram-positive bacteria. Methicillin resistance was 30.5% among the Staphylococcus aureus isolates. Most of Acinetobacter species isolates were resistant to piperacillin tazobactum (84.71%), meropenem (80%), and amikacin (87.06%). Other gram-negative bacteria were also emerging with multidrug resistance. The current study revealed the non-fermenting Gram-negative bacteria as the leading cause of burn wound infection and are highly resistant to available high-level antibacterial agents.The current study revealed the non-fermenting Gram-negative bacteria as the leading cause of burn wound infection and are highly resistant to available high-level antibacterial agents.