4%) > pH (31.1%) > SPC dose (28.5%). The two model were highly predictive with overall coefficients of determination and root-mean-square errors of 0.9983 and 0.31 for ANN, while 0.9996 and 0.20 for RSM-BBD. Overall, the present study established ANN and RSM-BBD as valuable and effective tools for catalytic SPC oxidation of IMD contaminants. SPC is a cleaner alternative to other oxidants for pesticide degradation as it is non-toxic, safe to handle, and produces by-products that inherently exist in the natural water matrix. Deoxynucleotides can be good monomers for arsenite ion-imprinted polymers (IIPs) due to the successful obtainment of aptamers which can specifically recognize arsenite. However, the recognition and interaction mechanism between arsenite and deoxynucleotides is still not clear. In this work, the binding interactions between arsenite and deoxynucleotides (dAMP, dTMP, dGMP, dCMP) as pH changing from 1 to 14 were investigated using density functional theory calculations as well as spectroscopy analysis. dGMP was calculated to have the largest affinity towards arsenite. H3AsO30-dGMP0 binding at phosphate group, H3AsO30-dAMP2-, H3AsO30-dCMP0 and H3AsO30-dTMP2- binding around nucleobase were found to be the most stable complexes. This suggests the optimal pH ranges for binding interactions of dAMP, dCMP, dGMP and dTMP towards arsenite might be 6.10-9.23, 1.00-4.50, 1.00-2.40 and 6.40-9.23, respectively, which agree with UV/VIS experimental results. Reduced Density Gradient method indicated that the binding interactions of arsenite with deoxynucleotides are mainly attributed to hydrogen bonds (H-bond). The strengths of these H-bonds are affected by pH. FT-IR and NMR spectroscopy analysis also provided essential H-bonding information, giving direct evidence to support the computational conclusions. Lead is a priority pollutant introduced in the aquatic environment by different sources commonly located in estuarine regions, such as ports, marinas and industries. Environmental agencies around the world set the maximum allowable concentration of lead in effluents, surface water and sediment, but few studies reported its accumulation and chronic toxicity in mangrove benthic invertebrates using concentrations believed to be safe. In the case of Brazilian mangrove environments, Ucides cordatus is a crab species of choice to be used in bioaccumulation studies. We have assessed biomarkers' responses (DNA strand breaks, micronucleated cells, metallothioneins, enzymatic activity of aminolevulinic acid dehydratase and neutral red retention time) and the total bioaccumulation in six tissues of U. cordatus crabs resident to mangrove areas under different conservation status during a 28-day period bioassay. We also investigated Pb subcellular partition and biomarkers' responses using a supposedly safe concentration (10 μg L-1). During the Pb exposure, the highest concentration of Pb was observed in crab gills. Crabs also showed a high ability to allocate Pb in detoxified forms. Multivariate analysis pointed out that bioaccumulation (total, active and detoxified) is linked to biomarkers. Even in supposedly safe dosage, U. cordatus triggered its defense mechanisms expressing more metallothioneins and presented relevant cyto-genotoxic damage. Our data suggest the development of biological tolerance to Pb in crabs from polluted areas. Our results provided a new insight about lead toxicity even at concentrations considered environmentally safe, which could support new strategies to manage estuarine areas considering their respective conservation status. Fumonisin B1 (FB1) is a mycotoxin frequently found in agricultural commodities, and poses a considerable risk for human and animal health. The aim of this study was to investigate the toxic effect of FB1 in mice intestine. Male Kunming mice (n = 40) were treated with FB1 diet for 42 days. Histopathological and biochemical analyses, including ion concentrations, transcription of ATPase subunits and mRNA expression of cytochrome P450s (CYP450s) analyses were performed on duodenum, cecum and colon of mice. The results revealed that FB1 caused histological alterations, including partial shedding of villous epithelial cells and inflammatory cell infiltration. Furthermore, a significant change in Na+, K+ and Ca2+ in serum, and the mRNA expression of ATPase subunits and CYP450s in intestinal tracts were observed in FB1-exposed mice. Our results suggested that FB1 exposure induce histopathological injury via disrupting CYP isoforms transcription and triggering ion homeostasis imbalance in mice intestinal tracts. This study presents the first reported detections and concentrations of alkyl phenoxy-benzenesulfonate surfactants (APBS) in municipal wastewater. A semi quantitative direct injection LC/MS/MS method was developed. Samples of raw influent and final effluent were obtained from fourteen municipal wastewater treatment plants (WWTPs) at various locations in Canada and were analyzed for APBS, including five homologues of monoalkyldiphenylether disulfonates (MADS) and one monoalkyldiphenylether sulfonate (MAMS) homologue. APBS were detected in all 42 of the wastewater raw influent samples and in 37 of the 42 wastewater final effluent samples; the other 5 final effluent samples had trace levels below the minimum detection limit. https://www.selleckchem.com/products/kb-0742-dihydrochloride.html In the samples of raw influent from the fourteen municipal treatment plants, the dissolved concentrations of APBS (total) ranged from 0.9 to 13.6 μg/L. In samples of final effluent from the same plants the total APBS ranged from below detection to 4 μg/L. The APBS were more resistant to loss during wastewater treatment compared to previous studies of linear alkylbenzene sulfonates in wastewaters. The most effective wastewater treatments for removal of APBS were those that involved either secondary treatment with aeration or advanced treatment including biological nutrient removal. Available information on ecotoxicity is lacking for evaluating the impacts of APBS surfactants when released to the environment. Crown All rights reserved.Microplastics are abundant in municipal wastewater which is mainly from personal care products and laundry. In recent years, great attention has been given to microplastics removal in wastewater treatment. In this article, the study focusing on microplastics in wastewater has been evaluated with VOSviewer. It was found that the major interest was in identification, quantification and pollution of the microplastics in the wastewater, and their transportation and final destination during wastewater treatment processes. The major microplastics and their shapes in wastewater were reviewed. Our evaluation results were consistent with other reported that fibers and fragment were the majority in terms of shape and polyethylene terephthalare (PET), polyethylene (PE), polypropylene (PP), and polystyrene (PS) are the most presented microplastics in wastewater. During wastewater treatment, the removal route of microplastics from wastewater includes settling, adsorption, entrapment, interception, etc. It confirms that microplastics are just simply transferred from wastewater to sludge.