An Investigator Global Assessment (IGA) using a 6-point scale (from -1=worsening to 4=complete response/clear) was also conducted at 30days, along with a self-administered tolerability questionnaire. Statistical analysis was performed using SAS version 9. At 15days, a statically significant reduction from baseline in erythema severity (mean from 3.4±0.3 to 2.5±0.2) along with pruritus intensity (mean from 70±15.4mm to 40±9.5mm) was observed. At 30days, all evaluated parameters showed a further progressive statistically significant reduction from baseline. No relevant side effects were recorded. Our results suggest that the tested spay containing antiseptic/anti-inflammatory and anti-irritation agents may represent a valid therapeutic option for mild/moderate intertrigo.Our results suggest that the tested spay containing antiseptic/anti-inflammatory and anti-irritation agents may represent a valid therapeutic option for mild/moderate intertrigo. The management of acquired hypertrichosis (HT) is based on the search of the causes and subsequent specific treatment. However, simultaneous hair removal is important. No single method for hair removal is appropriate for all patients and skin areas. Treatment options are actually limited and clinical results are often unsatisfactory. Ornithine decarboxylase 1 (ODC1), an enzyme present in hair follicles, is considered as a potential target to inhibit hair growth. Only eflornithine hydrochloride, an inhibitor of ODC1, showed to be partially effective in the management of acquired HT. The aim of our study was to evaluate the potential inhibition of ODC1 activity by a cream containing 4% capryloyl glycine, an ODC1 inhibitor, and 1% glycine soy-fermented extract (soy isoflavonoids). Furthermore, we present the results of a placebo-controlled clinical study that evaluated the efficacy and tolerability of this cream. The ODC1 activity was detected by measuring absorbance at 340nm. In the presence of ODC1 inhibivity). All patients were considered evaluable. In 11 out of 12 patients (91.7%), who were treated with product A, an improvement was observed. No improvement was observed in patients treated with product B. The global assessment showed good efficacy in 7 patients (58.3%) and moderate efficacy in 5 patients (41.7%) treated with the product A. No efficacy was detected in patients treated with product B. The study cream showed to be effective in Caucasian, adult, female patients with hypertrichosis located on the forearms.The study cream showed to be effective in Caucasian, adult, female patients with hypertrichosis located on the forearms.CRISPR-Cas is a powerful DNA double-strand break technology with wide-ranging applications in plant genome modification. However, the efficiency of genome editing depends on various factors including plant genetic transformation processes and types of modifications desired. Agrobacterium infection is the preferred method of transformation and delivery of editing components into the plant cell. While this method has been successfully used to generate gene knockouts in multiple crops, precise nucleotide replacement and especially gene insertion into a pre-defined genomic location remain highly challenging. Here, we report an efficient, selectable marker-free site-specific gene insertion in maize using Agrobacterium infection. Advancements in maize transformation and new vector design enabled increase of targeted insertion frequencies by two orders of magnitude in comparison to conventional Agrobacterium-mediated delivery. Importantly, these advancements allowed not only a significant improvement of the frequency, but also of the quality of generated events. These results further enable the application of genome editing for trait product development in a wide variety of crop species amenable to Agrobacterium-mediated transformation. To describe ocular adverse events and retinal changes during fibroblast growth factor receptor (FGFR) inhibitor (AZD4547) anticancer therapy. This is a sub-study examining ocular adverse effects from AZD4547 therapy (single-centre, open-label, single arm phase II clinical trial). Tepotinib chemical structure Comprehensive ocular examinations were performed 3 weekly in 24 patients. Macular optical coherence tomography (OCT) scan (30  × 25 ) was obtained at each visit and OCT parameters [central 1 mm retinal thickness (CRT) and total macular volume in central 6 mm] extracted. OCT scans were subdivided into outer (ELM to RPE) and inner (ELM to ILM) layers to compare outer and inner retinal changes. In 24 patients, AZD4547 was associated with eyelash elongation (n=5, 21%) and punctate corneal erosion (n=2, 8%). One patient developed clinically significant posterior capsular opacification during the study. OCT data were available in 23 patients, retinal changes ranged from an asymptomatic increased visibility of the interdigitation zone (IDZ) (n=10, 43%) to multilobular subretinal fluid pockets (n=5, 22%), which was associated with mild visual acuity loss. In a subset of patients (n=9) with pre-AZD4547 dosing OCT baseline, CRT increased by mean (SD) of 9 (4) μm in those with IDZ change only compared with 64 (38) μm in those with other retinal changes. Retinal changes tended to be bilateral, self-limiting and improved over time without medical intervention. The ocular signs and symptoms did not result in dose cessation. Posteriorly, FGFR inhibition leads to outer retinal changes ranging from increased visibility of IDZ to distinct, multiple fluid pockets.The ocular signs and symptoms did not result in dose cessation. Posteriorly, FGFR inhibition leads to outer retinal changes ranging from increased visibility of IDZ to distinct, multiple fluid pockets. Environmental concerns are driving the call for adoption of alternative nonchemical weeding approaches. This study aimed to develop and evaluate a novel, precise, low-energy electrophysical treatment weeding systems and to provide new insight into their control mechanism. Two electrophysical treatment systems, based on AC (2.2 kV) and DC (40 kV) energy sources, were developed and evaluated. The impacts of various operational and biological factors on the weed control effectiveness were evaluated. Additionally, thermal images were taken during the treatments to document plant temperature. Treatments via direct leaf contact caused greater damage to Amaranth plants than the stem contact treatments, with 75% and 20% biomass reduction compared to control, respectively. Treatment of early growth stages was favorable over later growth stages, with 100% and 75% biomass reduction for Trifolium pretense plants treated with 0.0125 W h 2 and 4 weeks after seeding, respectively, compared to control. Additionally, the applied energy affected treatment performance, with its impact varying across the growth stages and species; at the two-leaf growth stage, 0.