As EA cognitive abilities increase after age 8, the application of this project in even younger children indicates that a state of general well-being requires enough emotional awareness to be perceived. The traditional medical system of Ayurveda is widely practiced in India. Using the treatment principles of Panchakarma, Ayurveda offers rehabilitation therapy for patients with stroke. Although Ayurvedic rehabilitation is popular and has proven benefits, the experiences of stroke survivors undergoing Ayurvedic rehabilitation have not yet been documented in the literature. To explore the experience of stroke survivors during rehabilitation in an inpatient Ayurvedic facility. A qualitative approach with a phenomenological method was used for the study. read more Semi-structured interviews were conducted with 6 patients who were post-stroke and receiving inpatient rehabilitation therapy in an Ayurvedic facility in India. Thematic analyses of the verbatim transcripts were done using Lindseth & Norberg's phenomenological methodology. The main themes that emerged were "aspiring for self-efficacy," "hopefulness" and "treatment acceptance," with subthemes such as "self-reliance," resilience," "finding meaning in life," "optimism," "spirituality," "therapeutic mileu" and "perceived social support." The study indicates that stroke survivors undergoing Ayurvedic rehabilitation therapy look forward to improved self-reliance and experience enhanced feelings of hope. The treatment modalities used for rehabilitation are acceptable to patients. Essentially, rehabilitation in an Ayurvedic facility provides a holistic uplift in the well-being stroke survivors.The study indicates that stroke survivors undergoing Ayurvedic rehabilitation therapy look forward to improved self-reliance and experience enhanced feelings of hope. The treatment modalities used for rehabilitation are acceptable to patients. Essentially, rehabilitation in an Ayurvedic facility provides a holistic uplift in the well-being stroke survivors. Bladder pain syndrome (BPS) is a devastating urologic condition characterized by irritative bladder symptoms, pelvic pain, and dyspareunia. First-line treatment includes dietary, self-care and behavioral modifications. The ancient practice of yoga is well suited to treat BPS, but evidence is lacking on its use. To investigate the feasibility and efficacy of an integrated yoga module on BPS outcomesas measured by self-reported questionnaires from baseline to 3 months after therapy. This was a prospective single-arm study of 8 patients who underwent 3 months of integrated yoga therapy. The treatment module was performed 3 to 4 times weekly at home with 1 session performed weekly in-office during the first month to ensure proper performance of postures. Patients completed questionnaires (Pelvic Pain and Urgency/Frequency Patient Symptom Scale [PUF], Pelvic Floor Impact Questionnaire - short form 7 [PFIQ-7], Short Form 36 questionnaire [SF-36], Pittsburgh Sleep Quality Index [PSQI]) at baseline and 3 monthsa module against a control group.Glioma is the most common malignant tumor in the central nervous system. Evidence shows that clinical efficacy of immunotherapy is closely related to the tumor microenvironment. This study aims to establish a microenvironment-related genes (MRGs) model to predict the prognosis of patients with Grade II/III gliomas. Gene expression profile and clinical data of 459 patients with Grade II/III gliomas were extracted from The Cancer Genome Atlas. Then according to the immune/stromal scores generated by the ESTIMATE algorithm, the patients were scored one by one. Weighted gene co-expression network analysis (WGCNA) was used to construct a gene co-expression network to identify potential biomarkers for predicting the prognosis of patients. When adjusting clinical features including age, histology, grading, IDH status, we found that these features were independently associated with survival. The predicted value of the prognostic model was then verified in 440 samples in CGGA part B dataset and 182 samples in CGGA part C dataset by univariate and multivariate cox analysis. The clinical samples of 10 patients further confirmed our signature. Our findings suggested the eight-MRGs signature identified in this study are valuable prognostic predictors for patients with Grade II/III glioma. Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder worldwide. Multiple metabolic disorders, such as hyperlipidemia, hyperglycemia, insulin resistance and obesity, have been reportedly associated with NAFLD, but little is known about the detailed mechanisms. Here, we explored the effects of multiple metabolic disorders, especially hyperglycemia on lipid accumulation in liver using several well-established animal models. We found that liver lipid deposition was increased in both type 1 diabetes and high-fat diet (HFD) induced hyperlipidemia models, suggesting that either hyperglycemia or hyperlipidemia alone or together was able to trigger NAFLD. Moreover, we tested whether miR-320, a miRNA promoting lipid accumulation in heart revealed by our previous study, also participated in NAFLD. Though miR-320 treatment further increased liver lipid deposition in type 1 diabetes and HFD-feeding mice, it showed no effect in leptin-receptor deficient db/db mice. Interestingly, miR-320 affected different target genes in cytosol and nucleus, respectively, which collectively led to liver lipid overload. Our findings illustrated the complex roles of miRNAs in subcellular fractions including nucleus and cytoplasm, which may lead to new insights into the mechanisms and treatment strategies for NAFLD in the future.Our findings illustrated the complex roles of miRNAs in subcellular fractions including nucleus and cytoplasm, which may lead to new insights into the mechanisms and treatment strategies for NAFLD in the future.Alternative splicing events are a major source of transcript and protein diversity in eukaryotes. Aberrant alternative splicing events have been increasingly reported in various cancers, including gastric cancer. To further explore the prognostic significance of alternative splicing events in gastric cancer patients, a comprehensive and systematic investigation was conducted by integrating alternative splicing event data and clinical information. Univariate Cox regression analysis identified 1383 alternative splicing events to be significantly associated with the overall survival of gastric cancer patients. Then, least absolute shrinkage and selection operator (LASSO) and multivariate Cox analyses were performed for the development of prognostic signatures. The final prognostic signature based on all seven types of alternative splicing events can act as an independent prognostic indicator after multivariate adjustment of several clinical parameters. Furthermore, the correlation and function analysis identified CELF2, BAG2, RBFOX2, PTBP2 and QKI as hub splicing factors, and the focal adhesion signaling pathway was most significantly correlated with survival-associated alternative splicing events.