Additionally, in order to further increase the capability of the algorithm in modeling particles of sizes comparable to the lattice spacing, we propose an improvement to the EI scheme, the complete equilibrium interpolation (CEI). This approach allows us to accurately capture the boundaries of the particle also when located between two fluid nodes. We evaluate the CEI performance in solving the dynamics of an under-resolved particle under analogous Stokes conditions and also for the case of a rotating ellipsoid in a shear flow. Finally, we show that EI and CEI are able to recover the correct flow solutions also at small, but finite, Reynolds number. Adopting the CEI scheme it is not only possible to detect particles with zero lattice occupation, but also to increase up to one order of magnitude the accuracy of the dynamics of particles with a size comparable to the lattice spacing with respect to the BB and the EI schemes.Vedolizumab (VDZ) has been approved for the treatment of inflammatory bowel diseases (IBDs) in patients aged ≥18 years. We report a case of a pediatric patient with Crohn disease (CD) who was successfully treated with VDZ. A 16-year-old female developed severe active pulmonary tuberculosis (TB) during treatment with infliximab (IFX). IFX was stopped, and TB treatment was started. After a 6-month regimen of standard TB medication, her pulmonary TB was cured; however, gastrointestinal symptoms developed. Due to the concern of the patient and parents regarding TB reactivation on restarting treatment with IFX, VDZ was started off-label. After the second dose of VDZ, the patient was in clinical remission and her remission was continuously sustained. Ileocolonoscopy at 1-year after VDZ initiation revealed endoscopic healing. Therapeutic drug monitoring conducted during VDZ treatment showed negative antibodies to VDZ. No serious adverse events occurred during the VDZ treatment. LXS196 This is the first case report in Korea demonstrating the safe and effective use of VDZ treatment in a pediatric CD patient. In cases that require recommencement of treatment with biologics after recovery of active pulmonary TB caused by anti-tumor necrosis factor agents, VDZ may be a good option even in pediatric IBD.Objective To evaluate the compliance rate and its impact factors of liver cancer screening for high-risk groups in urban areas of Henan Province from 2013 to 2019. Methods Residents of 40-74 years old in 8 cities of Henan province were selected to investigate the risk factors and liver cancer risk assessment. Subjects with high risk of liver cancer received AFP combined ultrasonography for screening. Chi-square tests were used to compare the differences in liver cancer screening participation rates between groups. Multivariate logistic regression models were applied to explore the potential factors correlating to the compliance of liver cancer screening. Results Overall, 3 6781 participants who met the inclusion criteria were included in this analysis, and 17 241 of them took the following liver cancer screening, yielding a participation rate of 46.87%. The participation rate varied greatly across cities, ranging from 62.50% to 38.59%. Moreover, the participation rate varied greatly across periods, ranging from 52.77% in 2014-2015 to 38.14% in 2013-2014. The multivariate Logistic regression analyses showed that female, older, high education degree, cigarette and alcohol intake, infrequent physical exercise, chronic hepatitis B, chronic hepatitis C, fatty liver, gallstones and a family history of liver cancer were inclined to accept liver cancer screening (P less then 0.05). Conclusions The overall participation rate of liver cancer screening among high-risk population is less than 50% in urban areas of Henan Province. Implement of effective interventions targeting the specific high-risk populations might improve the overall compliance rate of liver cancer screening in the future.Objective To provide the risk stratification method of hepatoblastoma (HB) suitable for implementation in China and explore the new treatment method for high-risk HB patients. Methods A total of 100 cases of children and adolescents under 18 years old with newly diagnosed HB in Sun Yat-sen University Cancer Center and Sun Yat-sen University First Affiliated Hospital from September 2014 to September 2018 were included. According to the clinical stage, AFP level, pathological subtype and other factors, patients were stratified into four groups extremely low-, low-, intermediate- and high-risk. The patients at very low risk were treated with surgery only and followed-up. The patients at very low risk were treated with C5V(Cisplatin+ 5-Fluroracil+ Vincristine) regimen for 4 courses. The patients at intermediate risk were treated with C5VD(Cisplatin+ 5-Fluroracil+ Vincristine+ Doxorubicin)regimen before and after surgery for 6-8 courses. The patients at high risk were treated with C5VD and IIV (ifoshamide+ irinote low-, low- and medium-risk have excellent outcomes. The survival rate of high-risk HB patients remains to be improved, and new treatment strategies need to be explored.Objective To evaluate emergency interventional embolization in treating intractable tumor bleeding in head and neck cancer. Methods From February 2017 to February 2019, a total of 21 patients underwent emergency interventional embolization for the management of intractable tumor bleeding in head and neck cancer in Cancer Hospital, Chinese Academy of Medical Sciences. The tumor treatment history, bleeding history, angiography performance, technical success rate, clinical success rate and complications were retrospectively analyzed. Results The positive rate of angiography was 100% (21/21). Selective angiogram revealing abnormal tumor staining in 11 cases, contrast media extravasation in 5 cases, pseudoaneurysm in 2 cases, arteriovenous malformation in 2 cases and external carotid artery rupture in 1 case. One patient with carotid rupture was transferred to a general hospital for treatment. The remaining 20 patients received a total of 22 times of interventional embolization. The technical success rate was 100% (22/22).