The Mendoza River streamflow, South America (∼32 °S), derives almost exclusively from winter snow precipitation falling in the Andes. Almost 70% of the water feeding the river originates in the Cordillera Principal geological province. In addition to the snow that precipitates in this area, there are 951 cryoforms providing meltwater to the upper catchment. Given the high inter-annual variability of snowfall and the megadrought affecting the region since 2010, it is crucial to quantify the contribution from different water sources buffering the Mendoza River runoff. Combining instrumental records of streamflow from glaciers and rivers, meteorological data, remote sensing of snow-covered areas and ionic and stable isotope analysis of different water sources, this study attempts to understand the hydrological contribution of different water sources to the basin. We demonstrated for the first time the relevance of different water sources in addition to snow in a dry period. During the melting season, 65% of the streamwaters originated from the glaciers (i.e. 50 and 15% from glaciers and rock glaciers, respectively), representing a higher proportion compared to snowmelt (17%). Groundwater input showed relatively large contributions, averaging 18%. This work offers information to develop adaptation strategies for future climate change scenarios in the region. To determine whether circadian blood pressure (BP) variation of women with preeclampsia (PE) with severe features was associated with adverse maternal/perinatal outcomes. 173 women with PE with severe features were recruitedand categorized into three groups dipper, non-dipper and reverse dipper type BP group.. Maternal and perinatal outcomes were compared among groups. There were significant differences in gestational ages, premature delivery, retinopathy, HELLP syndrome, mean birth weight, rate of low birth weight infants and fetal growth restriction. Aberrant circadian pattern of BP in women with PE with severe features was associated with several adverse maternal/perinatal outcomes.Aberrant circadian pattern of BP in women with PE with severe features was associated with several adverse maternal/perinatal outcomes.Background Numerous studies, ranging from the alleviation of tissue ischemia to the assessment of cancer prognosis, have demonstrated the fundamental biological differences between human umbilical cord blood-derived endothelial progenitor cells (CB-EPCs) and adult peripheral blood-derived endothelial progenitor cells (PB-EPCs). However, the underlying molecular mechanisms that produce these differences are not clear.The purpose of this study was to identify potential hub genes, key protein interactive networks, and correlated signal pathways unique to CB-EPC biology via bioinformatic methods. Materials and Methods We selected the microarray dataset GSE39763 and identified the differentially expressed genes (DEGs) using the "limma" package in the RStudio software. These DEGs were annotated by gene ontology enrichment analyses and signal pathway analyses. A protein-protein interaction (PPI) analysis was then performed to construct PPI networks and identify a hub protein module. We further validated candidate DEf the CENPF and NUF2 genes in tumor patients were significantly higher than those in the controls. Conclusion The CB-EPCs express genes with greater potential for proliferation and increased migration compared to PB-EPCs; in this regard they are similar to cancer cells. To analyze the influences of mild and severe intracranial hypertension on cerebral autoregulation (CA). Duroc piglets were monitored with an intracranial pressure (ICP) catheter. Intracranial hypertension was induced via infusion of 4 or 7ml of saline solution by a bladder catheter that was inserted into the parietal lobe. The static cerebral autoregulation (sCA) index was evaluated via cerebral blood flow velocities (CBFv). Selleck Atuveciclib Piglets with ICPs ≤ 25 and > 25mmHg were considered as group 1 and 2, respectively. Continuous variables were evaluated using the Kolmogorov-Smirnov goodness-of-fit test. The main parameters were collected before and after ICH induction and compared using two-factor mixed-design ANOVAs with the factor of experimental group (mild and severe ICH). In group 1 (ICP ≤ 25mmHg), there were significant differences in sCA ( =.01) and ICP ( =.0002) between the basal and balloon inflation conditions. In group 2 (ICP > 25mmHg), there were significant differences in CBFv ( =.0072), the sCA index ( =.0001) and ICP ( =.00001) between the basal and balloon inflation conditions. We conclude that intracranial hypertension may have a direct effect on sCA.We conclude that intracranial hypertension may have a direct effect on sCA. To describe the experiences of applying aquatic therapy (AT) to children with ventilation needs after discharge from the paediatric intensive care unit (PICU). A qualitative and descriptive case study with integrated units. Purposive sampling was carried out, including the parents of the children participating in the AT programme and the healthcare professionals treating them. Fourteen participants were included four parents, five physicians, three physiotherapists and two nurses. The study was carried out as part of a program on AT in critically ill children. Semi-structured interviews were conducted. A thematic analysis was performed. Three themes were identified. Theme (1) Difficulties for implementation AT was not perceived as a viable therapeutic modality; lack of knowledge and resources. Theme (2) Risks and challenges Perceptions of anxiety at the beginning; planning and precautions. Theme (3) AT facilitates new possibilities and benefits The necessity of the presence of parents during the AT sessy of life of both children and their parents. Aquatic therapy is a feasible intervention in children requiring prolonged mechanical ventilation, although certain difficulties should be addressed in terms of implementation, together with challenges regarding safety and planning. These difficulties may be overcome by promoting coordination between professionals, creating security protocols, and/or facilitating specialised education for therapists.