A novel polymeric monolith using N,N-dimethylaminoethyl methacrylate as the monomer and ethylene glycol dimethacrylate as the crosslinker was successfully synthesized in a syringe and applied for direct solid-phase extraction of four benzodiazepines (bromazepam, triazolam, midazolam and diazepam) from undiluted urine samples prior to high performance liquid chromatography. The monolith was characterized by scanning electron microscopy, Fourier transform infrared spectroscopy and nitrogen adsorption-desorption experiments. Moreover, extraction parameters, including loading, washing and eluting conditions were optimized. Under the optimized conditions, the proposed method obtained linear ranges of 2.0-500 ng mL-1 with correlation coefficients (r) higher than 0.9997. The limits of detection (S/N = 3) and limits of quantification (S/N = 10) were 0.4-0.6 ng mL-1 and 1.4-2.0 ng mL-1, respectively. The recoveries at three spiked levels ranged from 83.7% to 103% with the intra- and inter-day precisions from 0.6-7.6% to 2.7-9.8%. The present monolith allowed direct loading of crude urine samples without any filtration or dilution step. Besides, the sorbent offered an enhancement factor of 16.7-20.6 and was stable enough for ten replicate cycles of extraction/desorption of urine samples. The developed method presented an alternative strategy for the accurate and convenient determination of benzodiazepines in urine samples.Understanding the chemical mechanism of crystal nucleation at the molecular level is crucial for the design of architectural structures of valuable materials in the future. In this study, it has been revealed that amorphous silicate precursors, which play a role in the nucleation processes of zeolitic frameworks, can be regularly fragmented in mass spectroscopy due to the hydroxyl functional groups in their molecular structures. In this way, by using the mass spectra acquired from LDI-TOF MS, the systematic evolution stages of a common 1D precursor converting to the 3D unit cells of MFI and MOR zeolite structures observed in the same reaction medium were constructed through a nucleation mechanism at the molecular level for the first time. Here we show a novel nucleation pathway that does not occur via stochastic assembly of atoms or distinct building blocks by molecular recognition. Each of the proposed nucleation mechanisms of these different frameworks carrying structural similarities is from different combinations of sequential self-attaching intramolecular covalent couplings of identical origin precursors. The dynamic molecular structure capable of forming finite building units of target frameworks during the nucleation process of this precursor, which is the polymerized form of simple 6-membered siloxane chains, has been arranged around structure directing agents before a hydrothermal reaction.The integration of semiconductors and polyoxometalates provides promising benefits for the rational tuning of hybrid materials' electronic band structures; however, the intrinsic influence of certain hybridization approaches on the resulting bandgaps of their complexes has seldom been noted. Herein, graphitic carbon nitride and a series of phosphovanadomolybdates (H3+xPMo12-xVxO40, x = 0-3) have been complexed through electrostatic charge attraction, and their optical and electronic properties are fully explored to investigate the effect of minor variations of the polyoxometalate structures on the hybrid bandgaps and electronic structures. The conduction band edge of the hybrids increases along with the expansion of the number of vanadium centers in the phosphovanadomolybdate, providing potential guidance for the design of hybrid catalysts.Correction for '4D synchrotron microtomography and pore-network modelling for direct in situ capillary flow visualization in 3D printed microfluidic channels' by Agnese Piovesan et al., Lab Chip, 2020, 20, 2403-2411, DOI .Boron containing catalysts have great potential in the oxidative dehydrogenation of propane. Herein, a series of 15, 25 and 42 at% boron-hyperdoped silicon catalysts synthesized by laser pyrolysis was studied. Boron-hyperdoped silicon samples showed >6 times higher propylene productivity than commercial h-BN at 450 °C.Metal-organic frameworks (MOFs) are generally synthesized in toxic formamide solvents. Greener solvents would lower production barriers and facilitate applications such as drug delivery. N,N-Diethyl-3-methylbenzamide (DEET), the most widely used insect repellent, is shown to serve this role. Furthermore, DEET-loaded MOFs can be leveraged in controlled-release insect repellent formulations.The conversion of glycerol selectively to lactic acid has been accomplished in high yields (ca. 90%) by using a NNN pincer-Ru catalyst. DFT explains the role of the Ru-P bond and sterics in favoring the catalysis.BACKGROUND Priapism is rarely reported as a complication in patients with essential thrombocythemia at presentation. We could find very few such cases of essential thrombocythemia while searching the literature. A combined modality of treatment is used in the form of chemotherapy and procedures like repeated aspiration and instillation of phenylephrine to treat essential thrombocythemia presenting with recurrent priapism. CASE REPORT A 31-year-old man presented to the Urology Department with priapism for the last 24 h. He had previously had multiple similar episodes in the last 20 days and 1 episode of prolonged penile erection 5 months ago. On examination, his penis was erect, swollen, and painful. There was no organomegaly. The priapism was managed with repeated aspiration and instillation of phenylephrine. Routine investigations showed marked thrombocytosis. Subsequent investigations done in the Clinical Hematology Department revealed increased megakaryocytes in bone marrow and presence of JAK2V617F mutation. After confirmation of diagnosis, cytoreductive therapy (hydroxyurea 500 mg twice a day) and acetyl salicylic acid 75 mg once a day was initiated. With this treatment, the platelet count normalized over a period of 2 months and no further episodes of priapism were noted; however, the patient developed erectile dysfunction. learn more CONCLUSIONS Essential thrombocythemia can present with priapism as the first manifestation. Early suspicion, diagnosis, and management is needed to prevent erectile dysfunction. Erectile dysfunction is usually irreversible after long-standing priapism.