Hydrogen, while being a potential energy solution, creates arguably the most important embrittlement problem in high-strength metals. However, the underlying hydrogen-defect interactions leading to embrittlement are challenging to unravel. Here, we investigate an intriguing hydrogen effect to shed more light on these interactions. By designing an in situ electron channeling contrast imaging experiment of samples under no external stresses, we show that dislocations (atomic-scale line defects) can move distances reaching 1.5 μm during hydrogen desorption. Combining molecular dynamics and grand canonical Monte Carlo simulations, we reveal that grain boundary hydrogen segregation can cause the required long-range resolved shear stresses, as well as short-range atomic stress fluctuations. Thus, such segregation effects should be considered widely in hydrogen research.Human technology is characterized by cumulative cultural knowledge gain, yet researchers have limited knowledge of the mix of copying and innovation that maximizes progress. Here, we analyze a unique large-scale dataset originating from collaborative online programming competitions to investigate, in a setting of real-world complexity, how individual differences in innovation, social-information use, and performance generate technological progress. We find that cumulative knowledge gain is primarily driven by pragmatists, willing to copy, innovate, explore, and take risks flexibly, rather than by pure innovators or habitual copiers. Our study also reveals a key role for prestige in information transfer.Microfibers are ubiquitous contaminants of emerging concern. Traditionally ascribed to the "microplastics" family, their widespread occurrence in the natural environment is commonly reported in plastic pollution studies, based on the assumption that fibers largely derive from wear and tear of synthetic textiles. By compiling a global dataset from 916 seawater samples collected in six ocean basins, we show that although synthetic polymers currently account for two-thirds of global fiber production, oceanic fibers are mainly composed of natural polymers. µFT-IR characterization of ~2000 fibers revealed that only 8.2% of oceanic fibers are synthetic, with most being cellulosic (79.5%) or of animal origin (12.3%). The widespread occurrence of natural fibers throughout marine environments emphasizes the necessity of chemically identifying microfibers before classifying them as microplastics. Our results highlight a considerable mismatch between the global production of synthetic fibers and the current composition of marine fibers, a finding that clearly deserves further attention.Owing to the rich porosity and uniform pore size, metal-organic frameworks (MOFs) offer substantial advantages over other materials for the precise and fast membrane separation. However, achieving ultrathin water-stable MOF membranes remains a great challenge. Here, we first report the successful exfoliation of two-dimensional (2D) monolayer aluminum tetra-(4-carboxyphenyl) porphyrin framework (termed Al-MOF) nanosheets. Ultrathin water-stable Al-MOF membranes are assembled by using the exfoliated nanosheets as building blocks. While achieving a water flux of up to 2.2 mol m-2 hour-1 bar-1, the obtained 2D Al-MOF laminar membranes exhibit rejection rates of nearly 100% on investigated inorganic ions. The simulation results confirm that intrinsic nanopores of the Al-MOF nanosheets domain the ion/water separation, and the vertically aligned aperture channels are the main transport pathways for water molecules.A recent paper in Science Advances by Miller et al. concludes that Graduate Record Examinations (GREs) do not help predict whether physics graduate students will get Ph.D.'s. Here, I argue that the presented analyses reflect collider-like stratification bias, variance inflation by collinearity and range restriction, omission of parts of a needed correlation matrix, a peculiar choice of null hypothesis on subsamples, blurring the distinction between failure to reject a null and accepting a null, and an unusual procedure that inflates the confidence intervals in a figure. Crenolanib research buy Release of results of a model that leaves out stratification by the rank of the graduate program would fix many of the problems.Gaussian Boson Samplers are photonic quantum devices with the potential to perform intractable tasks for classical systems. As with other near-term quantum technologies, an outstanding challenge is to identify specific problems of practical interest where these devices can prove useful. Here, we show that Gaussian Boson Samplers can be used to predict molecular docking configurations, a central problem for pharmaceutical drug design. We develop an approach where the problem is reduced to finding the maximum weighted clique in a graph, and show that Gaussian Boson Samplers can be programmed to sample large-weight cliques, i.e., stable docking configurations, with high probability, even with photon losses. We also describe how outputs from the device can be used to enhance the performance of classical algorithms. To benchmark our approach, we predict the binding mode of a ligand to the tumor necrosis factor-α converting enzyme, a target linked to immune system diseases and cancer.In 2018-2019, New York City experienced the largest measles outbreak in the United States in nearly three decades. To identify key contributing factors, we modeled the transmission dynamics of this outbreak. Results indicate that delayed vaccination of 1- to 4-year-olds enabled the initial spread and that increased infectious contact, likely via "measles parties," facilitated later transmission. We found that around half of infants were susceptible by age 1 and thus had many infections. Without the implemented vaccination campaigns, numbers of infections and hospitalizations could have been >10 times higher and would predominantly affect those under 4. These results suggest that a first vaccine dose before age 1 and the second dose before age 4 could allow parents to vaccinate and protect children more effectively should a high level of vaccine hesitancy persist. Enhanced public health education is needed to reduce activities that unnecessarily expose children to measles and other infections.