A retrospective study of 29 high-risk neuroblastoma (NB) patients treated at Shanghai Children's Hospital with high-dose chemotherapy and autologous stem cell transplantation (ASCT) from 2013 to 2021 involved an analysis of their clinical characteristics and long-term outcomes.Of the 29 children receiving high-dose chemotherapy along with ASCT, 18 (62%) were boys and 11 (38%) were girls, exhibiting a median age of disease onset of 36 months (interquartile range 27-59 months). Stage III neuroblastoma was diagnosed in 6 children (21%), according to the International Neuroblastoma Staging System, compared to 23 children (79%) diagnosed with stage IV. Initial spread was noted in bone (22 children, 76%), bone marrow (21 children, 72%), and intracalvarium (4 children, 14%). Hematopoietic function was completely restored in each of the 29 children who underwent ASCT. Twenty-five months (with a range of 17 to 45 months) after initial diagnosis, 21 out of the 29 children (72%) reported sustained complete remission, and 8 (28%) had a recurrence of their condition. etc-1002 After three years, the overall survival rate was 68.9%, and the event-free survival rate was 61.4%. These were paired with percentages of 16.1% and 14.4%, respectively. The presence of bone marrow metastasis, coupled with neuron-specific enolase levels of 370 ng/mL and positive bone marrow immunophenotyping, correlates with a lower three-year event-free survival rate.<005).Children suffering from high-risk neuroblastoma (NB), who have bone marrow metastasis discovered at initial diagnosis, usually experience a less favorable prognosis. The integration of ASCT with high-dose chemotherapy yields a more favorable prognosis for children diagnosed with neuroblastoma, while maintaining a positive safety profile.Children with neuroblastoma (NB), categorized as high-risk and presenting with bone marrow metastasis at initial diagnosis, typically have a poor prognosis. A favorable safety profile accompanies the use of high-dose chemotherapy and ASCT, which effectively improves the survival chances for children with neuroblastoma.Exploring the nature of vincristine-induced peripheral neuropathy (VIPN) in pediatric acute lymphoblastic leukemia (ALL) patients, and determining the factors that contribute to the onset and progression of this condition.From January 2018 to February 2022, the Affiliated Hospital of Guizhou Medical University enrolled children with ALL, aged 1-18 years, who received either the CCCG-ALL2015 or CCCG-ALL2020 treatment regimen as subjects in this study. The children's risk assessment was contingent upon their age, resulting in two groups: a 1-10 year group with 91 children, and an over-10-year age group with 29 children. Using the National Cancer Institute's Common Terminology Criteria for Adverse Events, 5th edition, VIPN was graded, and then the incidence, severity, and type of VIPN were contrasted among diverse groups.Among the 120 children enrolled in this study, 56 (46.7%) experienced the development of VIPN. Individuals over 10 years exhibited a substantially greater prevalence of VIPN, with 69% of this group affected, in contrast to the 1-10 year group with a rate of 40%.In a meticulous and deliberate manner, return the JSON schema containing a list of sentences. Within the group of 56 children affected by VIPN, a significant 12 (21%) exhibited grade 3 VIPN or above, and 44 (79%) displayed grade 2 VIPN. The incidence of autonomic nerve symptoms stood at 77 cases (597%), markedly higher than the 42 cases of peripheral nerve injury (325%) and 10 cases of cranial nerve injury (78%). Regardless of age, gender, risk profile, or treatment strategy, there were no appreciable differences in the nature and intensity of VIPN exhibited among the groups.According to this JSON schema, a list of sentences is to be provided. VIPN occurrence is correlated with age, as demonstrated by binary logistic regression analysis.>005).The occurrence of VIPN in children affected by ALL is comparatively high, with a peak in the manifestation of autonomic nervous system issues. The frequency of VIP cases is relatively high in children who are more than ten years old.A relatively high incidence of VIPN is observed in children having ALL, with the highest rate of occurrence associated with autonomic nervous system manifestations. Children over the age of ten exhibit a comparatively high rate of VIP incidence.A study on the sleep status and factors that increase the likelihood of sleep disorders among infants and young children in Jilin Province.From eight prefecture-level cities and one autonomous prefecture in Jilin Province, a sample of 1,080 healthy infants and young children, aged 0 to 3 years, were selected for the study. To ascertain the general characteristics of the subjects, a questionnaire developed by us was employed, coupled with the use of the Brief Infant Sleep Questionnaire for assessing sleep metrics. Multivariate logistic regression analysis was used for the purpose of understanding the risk factors contributing to sleep disturbances.A considerable 3824% (413 out of a total of 1080) of infants and young children demonstrated sleep-related issues, based on detection rates. Sleep duration in the 4-11 month, 12-24 month, and 25-36 month age categories registered higher values than the prescribed total sleep time.These sentences are now presented in a revised and distinct format. A multivariate logistic regression analysis revealed that full-term births, higher caregiver education levels, and increased daytime activity intensities were protective factors against sleep difficulties in infants and young children.Risk factors for sleep problems included lower vitamin D supplementation, frequent nighttime feedings, and maternal snoring, in contrast to factor (005), which exhibited a higher frequency.<005).While the total sleep time of Jilin Province's infants and young children older than four months surpasses recommended levels, the incidence of sleep disorders is correspondingly higher. Different factors contribute to the occurrence of sleep disruptions. Supplementation with vitamin D, in conjunction with providing education on infant sleep to primary caregivers and enhanced monitoring of preterm infants, can potentially lessen sleep-related issues in babies and toddlers.Infants and young children in Jilin Province, exceeding four months old, accrue more sleep hours than advised, but experience a higher percentage of sleep problems. Sleep problems are the result of an array of interacting elements. Focused follow-up care for preterm infants, alongside targeted sleep education for their primary caregivers, and the regular provision of vitamin D, can be beneficial in reducing sleep challenges in infants and young children.To investigate the correlation between skeletal muscle mass index (SMI) and the metabolic characteristics of obesity in adolescents, aiming to establish a foundation for preventing and managing adolescent obesity and its associated metabolic disorders.Researchers randomly selected 1,352 adolescents aged 12 to 18 in Yinchuan City, China, from October 2017 to September 2020 using stratified cluster sampling. This selection was followed by comprehensive assessments, including questionnaires, physical measurements, body composition analysis, and laboratory testing. Categorizing subjects based on both the diagnostic criteria for metabolic abnormalities and the definition of obesity using body mass index yielded four metabolic phenotypes: metabolically healthy normal weight, metabolically healthy obesity, metabolically unhealthy normal weight, and metabolically unhealthy obesity. The metabolic phenotypes' link to SMI was assessed using multivariate logistic regression analysis techniques.Compared to the metabolically healthy normal weight group, the SMI levels in the metabolically unhealthy normal weight, metabolically healthy obesity, and metabolically unhealthy obesity groups were lower.This JSON schema's output is a list of sentences structured in a certain way. A multivariate logistic regression, adjusting for age and sex, demonstrated that a higher body mass index (BMI) was a protective factor for adolescents in developing metabolically unhealthy normal weight, metabolically healthy obesity, and metabolically unhealthy obesity phenotypes.The three reported values are 074, 060, and 054, respectively.<0001).Minimizing the risk of metabolic problems and obesity is possible with a rise in SMI.A higher SMI could be linked to a diminished probability of developing metabolic health issues or obesity.In an effort to establish a basis for preventing non-alcoholic fatty liver disease (NAFLD) in overweight/obese children, this study aims to assess the prevalence of NAFLD in such children visiting a hospital, as well as to examine potential contributing factors.The study involved the recruitment of children categorized as overweight or obese from June 2019 to September 2021, who attended Hunan Children's Hospital. The study examined the percentage of individuals with NAFLD. Logistic regression analysis was used to scrutinize factors influencing the development of NAFLD, a condition categorized by non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH). To evaluate the predictive capability of contributing factors for NAFL and NASH, a receiver operating characteristic curve analysis was performed.Among the participants, 844 children, with ages between six and seventeen years, were found to be overweight or obese and were incorporated into the study group. Overweight/obese children experienced a significant NAFLD prevalence of 382% (322 out of 844 cases). Correspondingly, NAFL and NASH prevalence were 288% (243/844) and 94% (79/844), respectively. Multivariate logistic regression analysis found a significant correlation between an increase in waist-to-hip ratio (WHR) and low levels of high-density lipoprotein cholesterol (HDL-C), and the development of nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH).This JSON schema, a list of sentences, is requested. Evaluation using the receiver operating characteristic curve revealed a predictive association between the combination of WHR and HDL-C levels and NAFL, evidenced by an area under the curve of 0.653, with a 95% confidence interval applying.