A visual analog scale (VAS) on pain and the State-Trait Anxiety Inventory (STAI TX-1) were used to collect the data. The anxiety scores and pain levels were reduced in the intervention groups in comparison to the control group (P < .001). The anxiety scores weren't significantly different between the 2 intervention groups (P > .05), and the pain levels on the second day in intervention group 2 were lower than those of intervention group 1 (P < .05). While the pain levels were reduced in all groups (P < .001), the anxiety scores increased in the control group on the second day (P < .05) and decreased in the 2 intervention groups (P < .001). Music therapy can play an effective role in reducing pain and anxiety levels.Music therapy can play an effective role in reducing pain and anxiety levels. Evidence from multiple studies has revealed that it's meaningful to evaluate the clinical significance of CD146 because it's related to an early diagnosis of chronic renal failure as well as to the severity of illness and the patient's prognosis. The current study intended to evaluate the therapeutic effects of Shendibushen on the clinical parameters of blood and urine and on fibrosis in the kidney in a rat model, using simulated renal tissue fibrosis that was surgically induced with unilateral ureteral obstruction (UUO). Also, our research team intended to analyze the metabolic pathway activated by Shendibushen both in rat and human kidneys through use of the Kyoto Encyclopedia of Genes and Genomes (KEGG) database and the GeneNetwork. The aim is to discover if a connection existed between CD146 and key genes in these pathways. The research team conducted an animal study in Wistar rats. The rats were divided into 5 groups of 14 animals each (1) blank control group, (2) sham control group, (3) model grecreased the degree of renal interstitial fibrosis in the UUO rat model and reduced the serum creatinine, blood urea nitrogen, microalbumin, serum sCD146, and urinary sCD146 significantly compared to the model group (P < .05). Upon analysis of the metabolic pathways activated by Shendibushen, the study further verified, through use of the KEGG database, that CD146 activated the nuclear factor kappa B1 (NF-κB1) and transforming growth factor beta 1 (TGF-β1)/ SMAD family member 2 (SMAD2) pathways. CD146 could become an early indicator in clinical monitoring. CD146 has a function related to the NF-κB1and TGF-β1/ SMAD2 pathways under Shendibushen treatment.CD146 could become an early indicator in clinical monitoring. CD146 has a function related to the NF-κB1and TGF-β1/ SMAD2 pathways under Shendibushen treatment.Cultural competence and skills are the major part of professionalism a nurse should achieve to provide the best quality health care without hurting the culturally sensitive issues in all aspects. This review focused on the assessment of cultural competence and skills among nursing professionals. Assessment of these skills is very much necessary for accountability as well as improving the capability among the nurses or nursing professionals. Many tools are developed across the world including many region-specific. These tools can be employed for the self-assessment to know the self-competency and to assess the effectiveness of training programs among the professionals. Vitamins and their derivatives are used extensively in the field of dermatology to treat a range of conditions, both benign and malignant. Additionally, over the past decade, vitamin supplements have been heavily advertised for improving overall health. Due to the widespread use of vitamins and their derivatives for dermatologic conditions, a comprehensive review of the evidence is needed. Here we review several of the well-established uses of vitamins A, B, C, and D in the management of dermatologic conditions ranging from acne vulgaris to malignant melanoma. Additionally, we examine the dermatologic consequences of both deficiency and excess of vitamins A, B, C, and D. Finally, we delve into newer applications for these vitamins and evaluate the evidence behind them. Vitamins, in both topical and oral forms, play a key role in treating many dermatologic conditions. Some of the newer applications of vitamins, such as the use of vitamin B3 for non-melanoma skin cancer prevention, vitamin B6 for preventincer prevention, vitamin B6 for prevention of chemotherapy-induced alopecia, and vitamin C as an adjuvant treatment for malignant melanoma, appear promising. Further data is needed to validate these findings. Additionally, many people use vitamin B7 for hair, skin, and nail health. There is evidence that supports vitamin B7 supplementation in patients with uncombable hair syndrome, brittle nail syndrome, and seborrheic dermatitis. Some studies Some studies have also demonstrated a benefit in healthy individuals, although other studies have shown a neutral effect. Further randomized controlled trials are needed. Likewise, the use of vitamin D for the treatment of atopic dermatitis has conflicting results and requires further investigation. New research continues to emerge regarding vitamin supplementation, and it is an important topic for dermatologists. COVID-19 has spread rapidly around the world and reached pandemic proportions. With no definitive treatment to date, prevention is critical, and strengthening the immune system is a valuable tool in reducing the risk of infection. While the aging process can weaken the immune system, physical activity may boost it. The review intended to examine the interaction between the changes in the immune system during aging and the development of a COVID-19 infection, focusing on pathophysiological factors, and to evaluate whether regular physical activity can strengthen the immune system in older adults. The research team performed a narrative review by searching databases. During the COVID-19 pandemic, older people can stay active and healthy through playing sports such as yoga, walking, jogging, and cycling. VX-445 CFTR modulator Also, they can use online or virtual yoga and Pilates classes and videos, perform resistance exercises with minimal facilities at home, and do daily housework, such as gardening. In general, due to the positive role of regular exercise training on the immune system of the older adults as well as the involvement of the immune system in COVID-19, it's necessary to guide and implement home-based exercises for older adults.