Examination of prognostic factors for staying at work for long-term sick-listed workers with subjective health complaints (SHC) who partially work in a paid job, and to evaluate whether these factors are comparable with those of workers with other disorders. We used data of 86 partially sick-listed workers with SHC (57 females, 29 males, mean age 47.1 years) and 433 with other disorders (227 females, 206 males, mean age 50.9 years), from an existing prospective cohort study consisting of 2593 workers aged 18-65 years and registered as sick-listed with different health complaints or disorders for at least 84 weeks in the database of the Dutch Social Security Institute. We performed univariable logistic regression analyses (p ≤ 0.157) for all independent variables with the dependent variable staying at work for the workers with SHC. We then performed multivariable logistic regression analyses with forward selection (p ≤ 0.157) and combined the remaining factors in a final, multivariable model (p ≤ 0.05), which we also used for logistic regression analysis in the workers with other disorders. selleck chemical The following factors were significant prognostic factors for staying at work for workers with SHC full work disability benefits (odds ratio (OR) 0.07, 95% confidence interval (95% CI) 0.01-0.64), good mental health (OR 1.08, 95% CI 1.02-1.14), positive expectations for staying at work (OR 6.49, 95% CI 2.00-21.09), previous absenteeism for the same health complaint (OR 0.31, 95% CI 0.10-0.96) and good coping strategies (OR 1.13, 95% CI 1.04-1.23). For workers with other disorders, full work disability benefits, good mental health and positive expectations for staying at work were also prognostic factors for staying at work. Individual and policy factors seem to be important for staying at work of sick-listed workers with SHC and those with other disorders alike, but several biopsychosocial factors are particularly important for workers with SHC.Sustained attention is crucial for higher-order cognition and real-world activities. The idea that tactile training improves sustained attention is appealing and has clinical significance. The aim of this study was to explore whether tactile training could improve visual sustained attention. Using 128-channel electroencephalography (EEG), we found that participants with tactile training outperformed non-trainees in the accuracy and calculation efficiency measured by the Math task. Furthermore, trainees demonstrated significantly decreased omission error measured by the sustained attention to response task (SART). We also found that the improvements in behavioral performance were associated with parietal P300 amplitude enhancements. EEG source imaging analyses revealed stronger brain activation among the trainees in the prefrontal and sensorimotor regions at P300. These results suggest that the tactile training can improve sustained attention in young adults, and the improved sustained attention following training may be due to more effective attentional resources allocation. Our findings also indicate the use of a noninvasive tactile training paradigm to improve cognitive functions (e.g., sustained attention) in young adults, potentially leading to new training and rehabilitative protocols.Air pollution has become one of the most serious issues for human health and has been shown to be particularly concerning for neural and cognitive health. Recent studies suggest that fine particulate matter of less than 2.5 (PM2.5), common in air pollution, can reach the brain, potentially resulting in the development and acceleration of various neurological disorders including Alzheimer's disease, Parkinson's disease, and other forms of dementia, but the underlying pathological mechanisms are not clear. Astaxanthin is a red-colored phytonutrient carotenoid that has been known for anti-inflammatory and neuroprotective effects. In this study, we demonstrated that exposure to PM2.5 increases the neuroinflammation, the expression of proinflammatory M1, and disease-associated microglia (DAM) signature markers in microglial cells, and that treatment with astaxanthin can prevent the neurotoxic effects of this exposure through anti-inflammatory properties. Diesel particulate matter (Sigma-Aldrich) was used as a fineation. Astaxanthin attenuated these PM2.5-induced responses, reducing transcription of the proinflammatory markers iNOS and heme oxygenase-1 (HO-1), which prevented neuronal cell death. Our results indicate that PM2.5 exposure reformulates microglia via proinflammatory M1 and DAM phenotype, leading to neurotoxicity, and the fact that astaxanthin treatment can prevent neurotoxicity by inhibiting transition to the proinflammatory M1 and DAM phenotypes. These results demonstrate that PM2.5 exposure can induce brain damage through the change of proinflammatory M1 and DAM signatures in the microglial cells, as well as the fact that astaxanthin can have a potential beneficial effect on PM2.5 exposure of the brain.A core idea of attachment theory is that security develops when attachment figures are responsive to a person's connection needs. Individuals may be more or less secure in different relationships. We hypothesized that individuals who perceive a current relationship partner as being responsive to their needs will feel more secure in that specific relationship, and that the benefits of perceived partner responsiveness would be more pronounced for individuals who generally feel insecure. The current study included 472 individuals (236 couples) in romantic relationships. Consistent with our predictions, individuals who perceived more responsiveness from their partner displayed lower partner-specific attachment anxiety and partner-specific avoidance, especially when they were generally insecure. These findings are discussed in terms of the conditions that promote secure attachment bonds.The involvement of sleep in cognitive functioning is well known, but only a few studies have examined objective sleep parameters in children with high intellectual potential (HP). The main objective of this study was to compare sleep characteristics of 33 children with high intellectual potentialities (HP) (median 10 years old, 64% of boys) compared to 25 controls (median 11 years old, 64% of boys) and assess the difference between children with a homogeneous vs. a heterogeneous intelligence quotient (IQ) (i.e., a difference ≥15 points between verbal and non-verbal IQ). All children underwent a one-night polysomnography, an evaluation of intellectual quotient (IQ) and filled standardized questionnaires. Using non-parametric tests to compare groups' characteristics, we found that children with HP had more heterogeneous IQ, more rapid eyes movement (REM) sleep and tended to have less stage 1 sleep than controls. They also had more insomnia and sleep complaints. The high amount of REM sleep in children with HP could be advantageous for learning and could partially explain their gift.