The new era of immune and reconstitution therapy of autoimmune disorders is ongoing. However, endocrine autoimmune diseases comprise a group of elaborating pathologies where the development of new treatment strategies remains slow. Substitution of the missing hormones is still standard practice, taking care of the devastating symptoms but not the cause of disease. As our knowledge of the genetic contribution to the aetiology of endocrine disorders increases and early diagnostic tools are available, it is now possible to identify persons at risk before they acquire full-blown disease. This review summarizes current knowledge and treatment of endocrine autoimmune disorders, focusing on type 1 diabetes, Addison's disease, autoimmune thyroid diseases and primary ovarian insufficiency. We explore which new therapies might be used in the different stages of the disease, focus on legalized therapy and elaborate on the ongoing clinical studies for these diseases and the research front, before hypothesizing on the way ahead.A series of structurally differentiated α-cationic phospholes containing cyclopropenium, imidazolium, and iminium substituents has been synthesized by reaction of chlorophosphole 1 with the corresponding stable carbenes. Evaluation of the donor properties of these compounds reveals that their strong π-acceptor character is heavily influenced by the nature of the cationic group. The coordination chemistry of these newly prepared ligands towards AuI centers is also described and their unique electronic properties exploited in catalysis. Interestingly, α-cationic phosphole containing catalysts were not only able to accelerate model cycloisomerization reactions, but also to efficiently discriminate between concurrent reaction pathways, avoiding the formation of undesired product mixtures. The aim of this study was to clarify the immune mechanism of hepatic injury induced by periodontitis using a rat model. Twenty-four SPF male Wistar rats were randomly divided into two groups control group (CG) and periodontitis group (PG). In order to induce experimental periodontitis, we tied the wire ligature around bilateral maxillary first molar of rats. After 8weeks, the following indicators were valued gingival index, tooth mobility, probing pocket depth; indexes about oxidative stress and circulating biomarkers; bone retraction by micro-CT analysis; Toll-like receptor 4 (TLR4), myeloid differential protein-88 (MyD88), and nuclear factor kappa B (NF-κB) by qRT-PCR and Western blotting; tumor necrosis factor α (TNF-α), and interleukin-6 (IL-6) by qRT-PCR and immunohistochemical staining; inflammation of periodontal and hepatic tissues by histopathological observation. Periodontal indicators and micro-CT results showed the raised levels of inflammatory response and bone retraction in PG compared with CG. The mRNA and protein levels of TLR4, MyD88, NF-κB, TNF-α, and IL-6 have indicated high values in PG versus CG. Histopathological analysis revealed a correlation between periodontitis and hepatic injury. TLR4/MyD88/NF-κB pathway may play a role in periodontitis-induced liver inflammation of rats.TLR4/MyD88/NF-κB pathway may play a role in periodontitis-induced liver inflammation of rats. To present a comprehensive analysis of cytomorphological features, including clinical scenarios, for 8 cases (4 males, 4 females, aged 17-39 years, average=28.5) of, retrospectively diagnosed alveolar soft part sarcoma (ASPS), with TFE3 immunostaining in 7 cases. Conventional Papanicolaou and May Grunwald-Giemsa (MGG) stained smears and corresponding tissue sections were critically reviewed. Fine needle aspiration cytology was performed for primary diagnosis in 6 cases and for metastatic lesions in 2 cases. TFE3 and other immunohistochemical stains were tested using polymer detection technique. Tumour sites were thigh (n=6), shoulder (1) and neck (1). Tumour size (n=6) varied from 5 to 14.5 cm (average=7.2). Seven out of 8 cases were correctly diagnosed on cytosmears. The smears were mostly hypercellular (5), composed of cohesive clusters (8), including cell balls and pseudopapillae (3) and singly scattered cells (8). Tumour cells were round to oval, containing central to eccentric nuclei (8), abundant ntiating diagnoses, in an appropriate clinicoradiological context.We report a case of a pregnant woman with COVID-19 who developed coagulopathy in the absence of severe clinical symptoms. A polymerase chain reaction test of a vaginal swab was positive for SARS-CoV-2 RNA, suggesting a possibility of perinatal transmission. WST8 Cesarean delivery was performed because of a non-reassuring fetal heart rate; the placenta showed increased perivillous fibrin deposition and intervillositis. Moreover, placental infection with SARS-CoV-2 was demonstrated by placental immunostaining. The findings suggest a possible relationship between placental fibrin deposition and chronic and acute intervillositis, non-reassuring fetal heart rate and coagulopathy in pregnant women with COVID-19. © 2020 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology. The aim of this study is to examine the relationship between student nurses' nomophobia levels and obesity and self-esteem. This study is a descriptive-correlational type study. This study conducted 607 nursing students. Data were collected with "Personal Information Form,""Nomophobia Questionnaire (NMP-Q)," and "The Self Esteem Rating Scale-Short Form." As a result of the research, it was determined that the students had moderate nomophobia. There was no significant relationship between nomophobia and obesity and self-esteem. It was determined that especially when they are bored, the rate of using smartphones is high, and the use of smartphones harms their lives. More studies are needed to examine the relationship of nomophobia with students' body mass index and self-esteem.It was determined that especially when they are bored, the rate of using smartphones is high, and the use of smartphones harms their lives. More studies are needed to examine the relationship of nomophobia with students' body mass index and self-esteem.