Hypothesis Resilience will modify the relationship between stressors and well-being. Participants The sample included 1,010 college students, ages 18-26, from an urban Midwestern university. Methods A secondary analysis of cross-sectional data from an anonymous survey was conducted using multiple regression and simple slopes analysis. Results Resilience did not modify the relationship between stressors and well-being. Stressors (β = -.44, p less then .0001) and resilience (β = .33, p less then .0001) accounted for 42% of the variance in well-being (adjusted R2 = .42, F2,999 = 365.98, p less then .0001). The most frequently endorsed stressors were sleep problems, anxiety, and relationships. Conclusions Stressors and resilience warrant special attention in the allocation of resources and development of programs to improve student well-being. Learning opportunities in teaching hospitals are gated by clinical teachers. One way to unpack their decision-making is to employ a 'trust and risk' model. This study aimed to uncover clinical teachers' experience of trust, risk and vulnerability as they participate in medical education. Hospital-based clinical teachers were interviewed about trust, risk and vulnerability in medical education. Data analysis was undertaken using a constructivist, qualitative framework. Twenty demographically diverse clinical teachers participated. Trust and risk were regarded as fundamental workplace and teaching concepts. Their concerns fell into three domains of risk clinical, teaching and personal. Being trusted unlocked clinical learning opportunities, whereas trust failure limited future participation. Feeling trusted or not affected wellbeing and self-efficacy. Trust and risk pitfalls in education included bias, asymmetry and sidelining. This study adds to the literature by voicing clinical teachers' personal risks and vulnerabilities. Attention was drawn to the benefits of being perceived as trustworthy, and to the clinical, teaching and personal vulnerabilities of trust failure.If expert judgement of trustworthiness is to be legitimised as meaningful assessment, clinical teachers must be aware not only of how trust is built, but also the pitfalls of trust failure.This study adds to the literature by voicing clinical teachers' personal risks and vulnerabilities. Attention was drawn to the benefits of being perceived as trustworthy, and to the clinical, teaching and personal vulnerabilities of trust failure.If expert judgement of trustworthiness is to be legitimised as meaningful assessment, clinical teachers must be aware not only of how trust is built, but also the pitfalls of trust failure.Eukaryotic cells are exquisitely responsive to external and internal cues, achieving precise control of seemingly diverse growth processes through a complex interplay of regulatory mechanisms. The budding yeast Saccharomyces cerevisiae provides a fascinating model of cell growth in its stress-responsive transition from planktonic single cells to a filamentous pseudohyphal growth form. During pseudohyphal growth, yeast cells undergo changes in morphology, polarity, and adhesion to form extended and invasive multicellular filaments. This pseudohyphal transition has been studied extensively as a model of conserved signaling pathways regulating cell growth and for its relevance in understanding the pathogenicity of the related opportunistic fungus Candida albicans, wherein filamentous growth is required for virulence. This review highlights the broad gene set enabling yeast pseudohyphal growth, signaling pathways that regulate this process, the role and regulation of proteins conferring cell adhesion, and interesting regulatory mechanisms enabling the pseudohyphal transition. Expected final online publication date for the Annual Review of Genetics, Volume 55 is November 2021. P62-mediated mitophagy inducer concentration Please see http//www.annualreviews.org/page/journal/pubdates for revised estimates.Metal-organic frameworks (MOFs) have been widely recognized as one of the most fascinating classes of materials from science and engineering perspectives, benefiting from their high porosity and well-defined and tailored structures and components at the atomic level. Although their intrinsic micropores endow size-selective capability and high surface area, etc., the narrow pores limit their applications toward diffusion-control and large-size species involved processes. In recent years, the construction of hierarchically porous MOFs (HP-MOFs), MOF-based hierarchically porous composites, and MOF-based hierarchically porous derivatives has captured widespread interest to extend the applications of conventional MOF-based materials. In this Review, the recent advances in the design, synthesis, and functional applications of MOF-based hierarchically porous materials are summarized. Their structural characters toward various applications, including catalysis, gas storage and separation, air filtration, sewage treatment, sensing and energy storage, have been demonstrated with typical reports. The comparison of HP-MOFs with traditional porous materials (e.g., zeolite, porous silica, carbons, metal oxides, and polymers), subsisting challenges, as well as future directions in this research field, are also indicated.Using desorption electrospray ionization (DESI) as part of an automated high-throughput system, tandem mass spectra of the compounds in a pharmaceutical library were recorded in the positive mode under standardized conditions. Quality control filtering yielded an MS/MS library of 16 662 spectra. Fragmentation of subsets of the compounds in the library chosen to contain a single instance of a particular functional group (amide, piperazine, sulfonamide) was predicted by experts, and the results were compared with the experimental data. Expert performance was good to excellent for all the cases evaluated. Substituents on the functional groups were found to exert important secondary control over the fragmentation, with the main effect observed being product ion stabilization by aromatic substitution, which was consistent across the different groups evaluated. These substituent effects are generally explicable in terms of standard physical organic chemistry considerations of product ion stability as controlling fragmentation.