Standard treatment for HIV infection involves a combination of antiretrovirals. Additionally, opportunistic infections in HIV infected patients require further antimicrobial medications that might cause drug-drug interactions (DDIs). The objective of this study was to to compare the recognition of DDIs between antiretrovirals and antimicrobials by three proprietary databases and evaluate their concordance. 114 items of antiretrovirals and antimicrobials from the National List of Essential Medicines of Thailand 2018 were used in the study. However, 21 items were not recognised by Micromedex, Drugs.com, and Liverpool HIV interactions. Only 93 items were available for the detection of potential DDIs by the three databases. Potential DDIs detected from the three databases included 292 pairs. Liverpool showed the highest number of DDIs with 285 pairs compared with 259 pairs by drugs.com and 133 pairs by Micromedex. Regarding the severity classifications, Liverpool reported 10% Contraindicated; Micromedex reported 14% contraindicated and 59% major; Drugs.com reported 21% major. The Fleiss' kappa agreements were fair to poor among the three databases, higher agreement was observed for DDIs classified as severe. This study highlights the need to harmonize the evaluation and interpretation of DDI risk in order to produce standardized information to support prescribers.Species of the genus Tuber have gained a lot of attention in recent decades due to their aromatic hypogenous fruitbodies, which can bring high prices on the market. The tendency in truffle production is to infect oak, hazel, beech, etc. in greenhouse conditions. We aimed to show whether silver fir (Abies alba Mill.) can be an appropriate host partner for commercial mycorrhization with truffles, and how earthworms in the inoculation substrate would affect the mycorrhization dynamics. Silver fir seedlings inoculated with Tuber. aestivum were analyzed for root system parameters and mycorrhization, how earthworms affect the bare root system, and if mycorrhization parameters change when earthworms are added to the inoculation substrate. Seedlings were analyzed 6 and 12 months after spore inoculation. Mycorrhization with or without earthworms revealed contrasting effects on fine root biomass and morphology of silver fir seedlings. Only a few of the assessed fine root parameters showed statistically significant response, namely higher fine root biomass and fine root tip density in inoculated seedlings without earthworms 6 months after inoculation, lower fine root tip density when earthworms were added, the specific root tip density increased in inoculated seedlings without earthworms 12 months after inoculation, and general negative effect of earthworm on branching density. Silver fir was confirmed as a suitable host partner for commercial mycorrhization with truffles, with 6% and 35% mycorrhization 6 months after inoculation and between 36% and 55% mycorrhization 12 months after inoculation. The effect of earthworms on mycorrhization of silver fir with Tuber aestivum was positive only after 6 months of mycorrhization, while this effect disappeared and turned insignificantly negative after 12 months due to the secondary effect of grazing on ectomycorrhizal root tips.Objects differ from one another along a multitude of visual features. The more distinct an object is from other objects in its surroundings, the easier it is to find it. However, it is still unknown how this distinctiveness advantage emerges in human vision. Here, we studied how visual distinctiveness signals along two feature dimensions-shape and surface texture-combine to determine the overall distinctiveness of an object in the scene. Distinctiveness scores between a target object and distractors were measured separately for shape and texture using a search task. Apoptosis inhibitor These scores were then used to predict search times when a target differed from distractors along both shape and texture. Model comparison showed that the overall object distinctiveness was best predicted when shape and texture combined using a Euclidian metric, confirming the brain is computing independent distinctiveness scores for shape and texture and combining them to direct attention.This study aimed to replicate and validate concreteness and context effects on semantic word processing. In Experiment 1, we replicated the behavioral findings of Hoffman et al. (Cortex 63,250-266, https//doi.org/10.1016/j.cortex.2014.09.001 , 2015) by applying their cueing paradigm with their original stimuli translated into German. We found concreteness and contextual cues to facilitate word processing in a semantic judgment task with 55 healthy adults. The two factors interacted in their effect on reaction times abstract word processing profited more strongly from a contextual cue, while the concrete words' processing advantage was reduced but still present. For accuracy, the descriptive pattern of results suggested an interaction, which was, however, not significant. In Experiment 2, we reformulated the contextual cues to avoid repetition of the to-be-processed word. In 83 healthy adults, the same pattern of results emerged, further validating the findings. Our corroborating evidence supports theories integrating representational richness and semantic control mechanisms as complementary mechanisms in semantic word processing.The mammalian gut teems with microbes, yet how hosts acquire these symbionts remains poorly understood. Research in primates suggests that microbes can be picked up via social contact, but the role of social interactions in non-group-living species remains underexplored. Here, we use a passive tracking system to collect high resolution spatiotemporal activity data from wild mice (Apodemus sylvaticus). Social network analysis revealed social association strength to be the strongest predictor of microbiota similarity among individuals, controlling for factors including spatial proximity and kinship, which had far smaller or nonsignificant effects. This social effect was limited to interactions involving males (male-male and male-female), implicating sex-dependent behaviours as driving processes. Social network position also predicted microbiota richness, with well-connected individuals having the most diverse microbiotas. Overall, these findings suggest social contact provides a key transmission pathway for gut symbionts even in relatively asocial mammals, that strongly shapes the adult gut microbiota.