The CNN system provides fast and stable analytical outcome to improve work efficiency in IVF setting. To conclude, our CNN system is potential to be applied in practice for day-one human embryo segmentation as a robust tool with high precision, reproducibility and speed. Brachydactylies are a group of inherited conditions, characterized mainly by the presence of shortened fingers and toes. Based on the patients' phenotypes, brachydactylies have been subdivided into 10 subtypes. In this study, we have identified a family with two members affected by brachydactyly type A2 (BDA2). BDA2 is caused by mutations in three genes BMPR1B, BMP2 or GDF5. So far only two studies have reported the BDA2 cases caused by mutations in the BMPR1B gene. We employed next-generation sequencing to identify mutations in culpable genes. In this paper, we report a case of BDA2 resulting from the presence of a heterozygous c.1456C>T, p.Arg486Trp variant in BMPR1B, which was previously associated with BDA2. The next generation sequencing analysis of the patients' family revealed that the mutation occurred de novo in the proband and was transmitted to his 26-month-old son. Although the same variant was confirmed in both patients, their phenotypes were different with more severe manifestation of the disease in the adult.T, p.Arg486Trp variant in BMPR1B, which was previously associated with BDA2. The next generation sequencing analysis of the patients' family revealed that the mutation occurred de novo in the proband and was transmitted to his 26-month-old son. Although the same variant was confirmed in both patients, their phenotypes were different with more severe manifestation of the disease in the adult. Recurrent hemarthroses disturbing force/movement control are likely to impair postural balance. To investigate the possible changes in static postural balance parameters in children with haemophilia (CwH) and to reveal its relationship with Haemophilia Joint Health Score (HJHS). Twenty-one CwH aged 6-18 who had haemophilic arthropathy in at least one lower limb joint and 21 healthy peers were evaluated by using a force platform. Centre of pressure (CoP) signals were displayed as a map in both anteroposterior direction (APD) and mediolateral direction (MLD) by statokinesigram. Accordingly, the amplitude, velocity and standard deviation of CoP displacements along with the perimeter and ellipse area were measured. Assessments were made under eyes opened and eyes closed in bipedal stance for 60s. Joint health and muscle strength were evaluated with HJHS and digital dynamometer, respectively. Velocity and amplitude of CoP displacements in MLD were increased in CwH (p˂0.05). It was also found that these parameters were moderate correlated with the clinical score of the lower limb joints (p˂0.05). In CwH, standard deviation of CoP displacements in the APD was significantly higher in eyes closed, while standard deviation in MLD was significantly higher in eyes opened (p˂0.05). Disturbances during bipedal stance reveal the need for balance evaluation in CwH. Increased mediolateral oscillations may be an early sign of disorders of the musculoskeletal system in CwH. In addition to improving joint health, postural balance exercises that increase MLD stability have to be included in the rehabilitation programme of CwH.Disturbances during bipedal stance reveal the need for balance evaluation in CwH. Increased mediolateral oscillations may be an early sign of disorders of the musculoskeletal system in CwH. In addition to improving joint health, postural balance exercises that increase MLD stability have to be included in the rehabilitation programme of CwH. The fit alteration after ceramic layering of soft Cobalt-Chromium (Co-Cr) and zirconia is poorly documented. This study compared the marginal and internal fit of presintered Co-Cr and zirconia three-unit fixed dental prostheses before and after ceramic veneering. Co-Cr master model was prepared and duplicated 60 times to receive three-unit fixed dental prostheses (FDPs). Sixty dies were prepared, scanned and assigned to 3 groups (n = 20/group), to receive the FDPs made of presintered Co-Cr (CS), presintered zirconia (CZ) and cast Ni-Cr (Wi). Each framework was seated on its specific cast. A replica technique was used for marginal and internal discrepancy measurements in mesiodistal and buccolingual planes. Frameworks were ceramic veneered. Results were compared before and after ceramic layering within each group. D-Galactose cost Data were analyzed using the Levene, t test, and ANOVA (α = 0.05). Significant difference was found when gaps were compared within groups for CS and CZ but not for Wi. At the abutments level, significant difference was found for both premolars and molars in the buccolingual planes (p < 0.001). A multiple comparison between materials tested showed significant differences between presintered and cast Ni-Cr. No significant difference was detected between CS and CZ (p = 1.000). Although ceramic layering increased the discrepancy for presintered Co-Cr and zirconia, the marginal adaptation remained clinically acceptable.Although ceramic layering increased the discrepancy for presintered Co-Cr and zirconia, the marginal adaptation remained clinically acceptable.Trajectories of physical activity and sedentary time (SED) may differ between subgroups of youth. The aim of this study was to identify group-based dual trajectories of physical activity and SED and explore individual, social, and environmental correlates of these trajectories. Longitudinal data (three time points, baseline 2011-2012) of Spanish youth (n = 1597, mean age = 11.94 ± 2.52, 50.9% boys) were used. Moderate-to-vigorous physical activity (MVPA) and SED were assessed objectively at each time point, and 21 potential correlates were self-reported at baseline. Parallel process growth mixture models identified shared categorical latent groups, adjusting for school and age. Multinomial logistic regression models identified baseline correlates of a given trajectory. Four shared categorical latent groups were identified (1) stable MVPA and decreasing SED (4%); (2) stable MVPA and increasing SED (3%); (3) consistently higher MVPA (18%); and (4) stable low MVPA and slight increase in SED (75%). Multinomial logistic regression models with group 3 as reference found negative affect (RRR = 0.