5%) and the Young (-83.3%). ∆peak of NIRS total hemoglobin was lower in the Bedridden compared to that in the Young (-133%). All vascular inflammatory markers except IL-6 were significantly worse in the Bedridden compared to Old and Young. No differences were found between the Old and Young in inflammatory markers. Results of this study confirm that chronic physical constraint induces an exacerbation of vascular disfunction and differential regulation of vascular-related inflammatory markers. The mechanisms involved in these negative adaptations seems to be associated with endothelial dysfunction and consequent diminished NO-bioavailability likely caused by the reduced shear-rate consequential to long-term reduction of physical activity.INTRODUCTION Irritable bowel syndrome represents one of the most difficult gastroenterological diseases to treat, that usually induces the patients to follow different drug therapies, often not useful in symptom control. In this scenario low FODMAP diet could have positive effects in patients with irritable bowel syndrome, even because this type of diet regimen is characterized by a low gluten amount due to the exclusion of cereals. METHODS We enrolled 120 patients with irritable bowel syndrome, according to the Rome IV criteria, who were referred to Hepatogastroenterology Division of the University of Campania L. Vanvitelli from June to December 2018. They underwent a low FODMAP diet for six weeks, followed by a gradual weekly reintroduction of every category of food for three months. The patients had a follow-up evaluation for six months after the end of food reintroduction period. We measured abdominal pain with subjective numerical scale from 0 to 10. We evaluated other gastrointestinal symptoms with a questionnaire about symptoms of lower digestive tract, evaluating their frequency and intensity. We also evaluated the impact of irritable bowel syndrome on daily life with neurological bowel dysfunction score. RESULTS We obtained a good patient-adherence to diet and a statistically significant decrease of abdominal pain, bloating, flatulence, diarrhea, constipation, and neurological bowel dysfunction score (p less then 0.001) at the end of the diet. These results remained constant in the follow-up period. CONCLUSIONS We recommend the use of a low FODMAP diet regimen in patients with irritable bowel syndrome in order to control the symptoms and improve the quality of life.Few-bit analog-to-digital converter (ADC) is regarded as a promising technique to greatly reduce power consumption of Internet of Things (IoT) devices in millimeter-wave (mmWave) communications. In this work, based on the recently proposed parametric bilinear generalized approximate message passing (PBiGAMP), we propose a new scheme to perform joint symbol detection, channel estimation and decoding. The proposed scheme is flexible to deal with discrete prior on symbols, Gaussian mixture prior on channels and quantized likelihood on observations. Furthermore, we introduce doping factor to control the portion of "extrinsic" and "posterior" information with negligible complexity increase. Since this joint scheme can be implemented via fast Fourier transformation (FFT), the complexity grows only logarithmically. GSK525762A Compared to the benchmark algorithms, numerical results show that the proposed joint scheme can achieve significant performance gain, and demonstrate the effectiveness in dealing with the nonlinear distortion from few-bit ADC.Smartphones have emerged as a revolutionary technology for monitoring everyday life, and they have played an important role in Human Activity Recognition (HAR) due to its ubiquity. The sensors embedded in these devices allows recognizing human behaviors using machine learning techniques. However, not all solutions are feasible for implementation in smartphones, mainly because of its high computational cost. In this context, the proposed method, called HAR-SR, introduces information theory quantifiers as new features extracted from sensors data to create simple activity classification models, increasing in this way the efficiency in terms of computational cost. Three public databases (SHOAIB, UCI, WISDM) are used in the evaluation process. The results have shown that HAR-SR can classify activities with 93% accuracy when using a leave-one-subject-out cross-validation procedure (LOSO).Cellular broadband Internet of Things (IoT) applications are expected to keep growing year-by-year, generating demands from high throughput services. Since some of these applications are deployed over licensed mobile networks, as long term evolution (LTE), one already common problem is faced the scarcity of licensed spectrum to cope with the increasing demand for data rate. The LTE-Unlicensed (LTE-U) forum, aiming to tackle this problem, proposed LTE-U to operate in the 5 GHz unlicensed spectrum. However, Wi-Fi is already the consolidated technology operating in this portion of the spectrum, besides the fact that new technologies for unlicensed band need mechanisms to promote fair coexistence with the legacy ones. In this work, we extend the literature by analyzing a multi-cell LTE-U/Wi-Fi coexistence scenario, with a high interference profile and data rates targeting a cellular broadband IoT deployment. Then, we propose a centralized, coordinated reinforcement learning framework to improve LTE-U/Wi-Fi aggregate data rates. The added value of the proposed solution is assessed by a ns-3 simulator, showing improvements not only in the overall system data rate but also in average user data rate, even with the high interference of a multi-cell environment.Multipotent mesenchymal stem cells (MSCs) possess regenerative properties and have been shown to improve outcomes and survival in acute and chronic lung diseases, but there have been some safety concerns raised related to MSC-based therapy. Subsequent studies have demonstrated that many of the regenerative effects of MSCs can be attributed to the MSC-derived secretome, which contains soluble factors and extracellular vesicles (EVs). MSC-derived extracellular vesicles (MSC-derived EVs) replicate many of the beneficial effects of MSCs and contain a variety of bioactive factors that are transferred to recipient cells, mediating downstream signaling. MSC-derived EV therapy holds promise as a safe and effective treatment for pulmonary disease, but there remain many scientific and clinical questions that will need to be addressed before EVs are widely applied as a therapy. To date, the use of MSC-derived EVs as a treatment for lung disease has been conducted primarily in in vitro or pre-clinical animal models. In this review, we will discuss the current published research investigating the use of EVs as a potential therapeutic for acute lung injury/acute respiratory distress syndrome (ALI/ARDS), bronchopulmonary dysplasia (BPD), idiopathic pulmonary fibrosis (IPF), pulmonary arterial hypertension (PAH), asthma, and silicosis.