14, 0.14). These findings demonstrated that side-chain modification can be an effective strategy for developing efficient solution-processable blue light-emitting polymers.Surface properties of crystalline solids and the related defect disorder of the surface layer have a critical effect on the reactivity and performance of materials, including energy materials. It is shown here that a high-temperature electron probe enables unequivocal surface characterization of energy oxide materials in a gas/solid equilibrium, including the affinity-related charge transfer and segregation-affected defect disorder. As an example, this work considers in situ surface monitoring of barium titanate at elevated temperatures during oxidation to determine a quantity (described as work function) that is reflective of the chemical potential of electrons during gas/solid reactions. The probe enables insight into local surface structures and opens up new fields of surface defect chemistry and surface defect engineering of materials for clean energy conversion.Introduction In the elderly, impairment of kidney function occurs. Renal diseases overlap with anatomic and functional changes related to age-related involutionary processes. Mortality among patients with acute renal injury is approximately 50%, despite advances in treatment and diagnosis of AKI. The aim To assess the incidence of acute kidney injury in elderly patients and to analyze the causes of acute renal failure depending on age. Material and methods A retrospective analysis included medical documentation of patients hospitalized in the Nephrology Clinic during the 6-month period. During this period 452 patients were hospitalized in the clinic. A group of 77 patients with acute renal failure as a reason for hospitalization was included in the study. Results The prerenal form was the most common cause of AKI in both age groups. In both age groups, the most common cause was dehydration; in the group of patients up to 65 years of age, dehydration was 29.17%; in the group of people over 65 years - 43.39%. Renal replacement therapy in patients with AKI was used in 14.29% of patients. In the group of patients up to 65 years of age hemodialysis was 16.67% and above 65 years of age. -13.21% of patients. The average creatinine level in the group of younger patients at admission was 5.16 ± 3.71 mg / dl, in the group of older patients 3.14 ± 1.63 mg / dl. The size of glomerular filtration GFR in the group of younger patients at admission was 21.14 ± 19.54 ml / min, in the group of older patients 23.34 ± 13.33 ml / min. Conclusions The main cause of acute kidney injury regardless of the age group was dehydration. Due to the high percentage of AKI in the elderly, this group requires more preventive action, not only in the hospital but also at home.Introduction There are limited data on the relationship between the severity of community-acquired pneumonia (CAP), biomarkers of inflammation and coagulation as well. The aim was to evaluate the association between the severity of CAP and risk of thrombosis in patients with moderate and severe CAP. To estimate the role of parameters of systemic inflammation, endothelial dysfunction, hemostasis, coagulation on different phases of treatment. Material and methods The main group was 75 patients CAP. We divided the main group according severity subgroup 1 – 41 patients with moderate CAP, subgroup 2 – 34 patients with severe CAP. Blood coagulation test, determination of biomarkers was performed at admission before starting of antibacterial treatment and after clinical stability on 7–10 day after hospitalization. Results We found that in both subgroup 1 and subgroup 2 the mean levels of CRP and fibrinogen were higher than in control group. Moreover, the mean level of D-dimer was significantly higher and protein C (PC) was significantly lower in both subgroups in comparison with control group. Normalization of PC is coming after 7–10 days of antibacterial treatment, vice versa ET-1, which reflects prolong endothelial dysfunction in patients with severe CAP. Conclusions Patients with severe CAP have the high risk of thrombosis which can be associated with endothelial dysfunction; definition of such parameters as ET-1 and PC can be useful for establishment of different coagulant disorders in patient with mild and moderate CAP, and their dynamic changes could be the initial point of prescribing or cancelling of anticoagulant treatment.Introduction Children and adolescents with hematological diseases are constantly in a state of prolonged psychological stress caused by hospitalization, debilitating treatment, lifestyle changes, which ultimately leads to a significant reduction in the quality of life. In this connection it is necessary to study the dynamics of mental and emotional condition of the child at different stages of chemotherapy and the timing of formation of asthenic syndrome. The aim Determine the presence of psycho-emotional disorders and the severity of asthenic syndrome in children with acute leukemia after the first stage of chemotherapy in order to further predict the development of this pathology and develop a package of solutions that minimize its manifestations. Material and methods A survey of 36 children was conducted, of them 21 people aged 6–10 years old, 15 people aged 11–16 years old. There are 27 boys (75%) and 9 girls (25%). The survey was conducted on the 78th day of the ALL IC-BFM 2009 protocol, which correspondso within the framework of a favorable state in both groups. Also during the investigation revealed that the general for all children is a symptom asthenic. According to the data, fatigue reaction (less than 7 points) was present only in 9 children (25%). The most numerous manifestations were moderate asthenia - 21 children (58%). Severe asthenia (13 - 18 points) was observed only in 6 children (17%). Conclusions This study will allow to develop a package of solutions for the prevention and minimization of asthenic syndrome in children with acute leukemia receiving chemotherapy.OBJECTIVE It is well established that the cortico-striato-thalamo-cortical (CSTC) circuit is implicated in the pathophysiology of obsessive- compulsive disorder (OCD). However, reports on corticostriatal functional connectivity (FC) in OCD have been inconsistent due to the structural and functional heterogeneity of the striatum. Volasertib nmr Therefore, in the present study, we investigated corticostriatal FC using a fine 12-seed striatal parcellation to overcome this heterogeneity and discover the neural correlates of symptoms in OCD patients. METHODS We recruited 23 OCD patients and 23 healthy controls (HCs). Whole-brain FC based on striatal seeds was examined using resting-state functional magnetic resonance imaging data and compared across OCD patients and HCs. We conducted correlation analysis between FCs of striatal subregions with significant group differences and symptom severity scores on the Yale-Brown Obsessive Compulsive Scale (Y-BOCS), Hamilton Rating Scale for Depression, and Hamilton Rating Scale for Anxiety (HAM-A).