Frogs thus seem to encounter favorable habitat conditions after pollution in postwar Berlin improved, but no such tendencies were observable in the predominantly agricultural landscape of Brandenburg. Urbanization, characterized by the proportion of built-up area, was not the main associated factor for the observed trait changes. However, we detected a relationship with the amount of urban greenspace. Our study exemplifies that increasing urbanization must not necessarily worsen conditions for species living in urban habitats. The Berlin example demonstrates that public parks and other urban greenspaces have the potential to serve as suitable refuges for some species. These findings underline the urgency of establishing, maintaining, and connecting such habitats, and generally consider their importance for future urban planning.Curved polycyclic aromatic hydrocarbons exhibit intriguing properties, but their flexible and dynamic nature is often considered to be unfavorable for achieving excellent emission properties. In this study, we prepared tetrathia[8]circulene octaoxides that adopt a negatively curved conformation. We found that these molecules exhibit aggregation-induced emission (AIE) that originates from the restriction of the dynamic motion of their saddle-shaped π-frameworks in the solid and aggregated states.Burnout among physicians and dermatologists is gaining a wide attention in the recent decade. The aim of this cross sectional study was to assess the prevalence and predicting factors for burnout among Egyptian dermatologists. A cross sectional study was designed and data were collected using structured open access survey. A total of 144 dermatologists completed the full questionnaire. The majority of dermatologists completing the survey 85 (59%) were between 30 and 40 years age group while those above 50 years of age represented a minority 10 (6.9%). The Mean score of emotional exhaustion was 29.24 ± 12.73 (high) while that of personal accomplishment was 29.14 ± 9.24 (moderate) and for depersonalization was 10.07 ± 6.46 (moderate). We demonstrated high burnout prevalence among Egyptian dermatologist that needs to be further verified by other randomized studies. Being a resident dermatologist living in a rural locality and with more than 8 daily working hours were significant predictors of increased burnout rates.Bromodomain and extra-terminal (BET) family proteins, BRD2-4 and T, are important drug targets; however, the biological functions of each bromodomain remain ill-defined. Chemical probes that selectively inhibit a single BET bromodomain are lacking, although pan inhibitors of the first (D1), and second (D2), bromodomain are known. Here, we develop selective BET D1 inhibitors with preferred binding to BRD4 D1. In competitive inhibition assays, we show that our lead compound is 9-33 fold selective for BRD4 D1 over the other BET bromodomains. X-ray crystallography supports a role for the selectivity based on reorganization of a non-conserved lysine and displacement of an additional structured water in the BRD4 D1 binding site relative to our prior lead. Whereas pan-D1 inhibitors displace BRD4 from MYC enhancers, BRD4 D1 inhibition in MM.1S cells is insufficient for stopping Myc expression and may lead to its upregulation. Future analysis of BRD4 D1 gene regulation may shed light on differential BET bromodomain functions. The term "difficult sedation" (DS) refers to situations of therapeutic failure, tolerance, or deprivation of the sedatives administered. To characterize the profile of patients who developed DS and to assess its impact on the duration of mechanical ventilation (MV) and intensive care unit length of stay (ICU-LOS), as well as other complications related to their stay. A prospective descriptive analysis was conducted of the practices of analgesia/sedation in a medical-surgical intensive care unit (ICU) over a 2-year period. All critically ill patients undergoing MV and sedation for more than 24 hours were prospectively followed until death or discharge. Dorsomorphin cell line Demographic data, type, duration, complications of analgesia/sedation, and clinical outcome during ICU stay were recorded. Patients who developed DS were compared with those who were not difficult to sedate (not-DS). A total of 327 patients were included, 24.1% of whom were difficult to sedate (DS). Patients in the DS group were younger (P = .001); lesl profile of this group and active prevention and treatment are essential strategies in order to minimize its impact. A quarter of mechanically ventilated patients may develop situations of DS, which negatively affects their outcome. Early detection and prevention of DS are essential to minimize its impact.A quarter of mechanically ventilated patients may develop situations of DS, which negatively affects their outcome. Early detection and prevention of DS are essential to minimize its impact.Oilseed rape residues are a crucial determinant of stem canker epidemiology as they support the sexual reproduction of the fungal pathogen Leptosphaeria maculans. The aim of this study was to characterize the impact of a resistance gene against L. maculans infection on residue microbial communities and to identify microorganisms interacting with this pathogen during residue degradation. We used near-isogenic lines to obtain healthy and infected host plants. The microbiome associated with the two types of plant residues was characterized by metabarcoding. A combination of linear discriminant analysis and ecological network analysis was used to compare the microbial communities and to identify microorganisms interacting with L. maculans. Fungal community structure differed between the two lines at harvest, but not subsequently, suggesting that the presence/absence of the resistance gene influences the microbiome at the base of the stem whilst the plant is alive, but that this does not necessarily lead to differential colonization of the residues by fungi. Direct interactions with other members of the community involved many fungal and bacterial amplicon sequence variants (ASVs). L. maculans appeared to play a minor role in networks, whereas one ASV affiliated to Plenodomus biglobosus (synonym Leptosphaeria biglobosa) from the Leptosphaeria species complex may be considered a keystone taxon in the networks at harvest. This approach could be used to identify and promote microorganisms with beneficial effects against residue-borne pathogens and, more broadly, to decipher the complex interactions between multispecies pathosystems and other microbial components in crop residues.