To develop a score to predict the need for intensive care unit (ICU) admission in Covid-19. We assessed patients admitted to a Covid-19 center in Mexico. Patients were segregated into a group that required ICU admission, and a group that never required ICU admission. By logistic regression, we derived predictive models including clinical, laboratory, and imaging findings. The ABC-GOALS was constructed and compared to other scores. We included 329 and 240 patients in the development and validation cohorts, respectively. Onehundred- fifteen patients from each cohort required ICU admission. The clinical (ABC-GOALSc), clinical+laboratory (ABC-GOALScl), clinical+laboratory+image (ABC-GOALSclx) models area under the curve were 0.79 (95%CI=0.74-0.83) and 0.77 (95%CI=0.71-0.83), 0.86 (95%CI=0.82-0.90) and 0.87 (95%CI=0.83-0.92), 0.88 (95%CI=0.84-0.92) and 0.86 (95%CI=0.81-0.90), in the development and validation cohorts, respectively. The ABC-GOALScl and ABC-GOALSclxoutperformed other Covid-19 and pneumonia predictive scores. ABC-GOALS is a tool to timely predict the need for admission to ICU in Covid-19.ABC-GOALS is a tool to timely predict the need for admission to ICU in Covid-19. To analyze the prevalence of modern contraceptive methods (CM) use in adolescents aged 12 to 19 years in 2012 and 2018-19, and the factors associated with consistent use of modern CM. Using the Health and Nutrition National Surveys 2012 and 2018-2019 we calculated the outcome variables long-acting reversible contraceptives (LARC) use, dual protection and consistent use of CM. We estimated prevalence by sex and adjusted logistic models with consistent use (which is understood as CM use in the first and last sexual relationship) as a dependent variable. LARC use in last intercourse increased between surveys (4.1 to 6.3%). https://www.selleckchem.com/products/eidd-2801.html For women, being older, not having been pregnant, and school attendance increased the likelihood of consistent use. For men, school attendance increases the likelihood while cohabiting, early sexual initiation and having smoked more than 100 cigarettes reduces it. It is necessary to promote access and consistent use of MC, based on respect for sexual and reproductive rights.It is necessary to promote access and consistent use of MC, based on respect for sexual and reproductive rights. Understand what Mexican key stakeholders think about the judicialization of the right to health in Mexico. 30 semi-structured interviews were conducted at different settings in Mexico City with representatives of the judiciary, legislative power, Health Sector (HS), pharmaceutical industry, academia and nongovernmental organizations from May 2017 to August 2018. Interviews were transcribed and analyzed based on different categories of interest. There are different opinions regarding judicialization of the right to health. Tensions exist between those who see its potential effect as a game changer for the HS and those who perceive it as an illegitimate interference of the judiciary. There is no coordinated strategy between sectors to promote change in the HS. There are different opinions regarding judicialization of the right to health in Mexico. There are tensions between those who see its potential effect as a game changer for the HS and those who perceive it as an illegitimate interference of the judiciary. Others argue that there is no coordinated strategy between sectors to promote change in the HS. All agree that judicialization in Mexico is a reality.There are different opinions regarding judicialization of the right to health in Mexico. There are tensions between those who see its potential effect as a game changer for the HS and those who perceive it as an illegitimate interference of the judiciary. Others argue that there is no coordinated strategy between sectors to promote change in the HS. All agree that judicialization in Mexico is a reality. Available data suggest the important role of ablation of the left atrial posterior wall and epicardial myocardial layers in rhythm control therapy in patients with persistent drug‑refractory atrial fibrillation (AF). However, endocardial ablation is not always effective in transmural substrate modification. The alternative treatment option is minimally invasive hybrid approach (HABL) combining the strengths of surgical and catheter ablation. This study aimed to assess the periprocedural safety as well as acute and long‑term outcomes of HABL for AF. This is a retrospective single‑center study of patients who underwent HABL using the minimally invasive transabdominal approach between July 2009 and January 2020. Demographic in‑hospital data and 12‑month follow‑up results were obtained. The number of hospitalizations, cardioversions, re‑ablations, and severe adverse events in a 3‑year period before and after HABL were compared using data from the national healthcare provider. In total, 158 patients (mean ative therapeutic option especially in patients with persistent AF.Heart failure with preserved ejection fraction (HFpEF) is an increasingly common condition, particularly in the context of the aging of the population. HFpEF is associated with high morbidity, mortality, and rate of heart failure rehospitalization as well as poor quality of life. Previous studies on HFpEF failed to reach a positive outcome. There is currently no approved treatment for HFpEF. The overall PARAGON‑HF trial population showed a 13% reduction in the primary endpoint (cardiovascular death and total heart failure hospitalizations) with sacubitril / valsartan treatment as compared with valsartan, which was of borderline statistical significance. Analyses of the secondary endpoints, including the clinical status, quality of life, and kidney function, imply that sacubitril / valsartan offers benefits compared with valsartan alone. The results of the PARAGON‑HF trial revealed that patients with HFpEF and particular clinical profiles (lower strata of ejection fraction below 57% and female sex), for whom no evidence‑based therapy is available, may benefit from treatment with sacubitril / valsartan. This review article summarizes opinions on the PARAGON‑HF results as well as a mechanistic discussion.