These results showed a significant difference between the H&E staining and D2-40 IHC study for LVI detection ( =0.004). The D2-40 IHC marker is helpful in the diagnosis and confirmation of LVI in invasive carcinoma of the breast. CD31 is not suitable for the evaluation of lymphatic vessels.The D2-40 IHC marker is helpful in the diagnosis and confirmation of LVI in invasive carcinoma of the breast. CD31 is not suitable for the evaluation of lymphatic vessels. Catecholamine is a typical index of exercise intensity, but it is difficult to detect. Plasma metanephrine (MN) and normethanephrine (NMN) levels are more stable than those of catecholamines. This study aimed to investigate plasma MN and NMN levels during acute exercise running in amateur runners. Samples were collected from eight healthy male participants. They were either sedentary or running at low or high intensity for 30 min. Blood samples were collected under these conditions. Measurements taken included plasma adrenaline, noradrenaline, MN, and NMN. Plasma adrenaline levels increased after high-intensity exercise compared with sedentary subjects. Plasma noradrenaline, MN, and NMN levels increased after both low- and high-intensity exercise compared with sedentary subjects. In addition, these levels were also significantly higher at high intensity than at low intensity. Plasma adrenaline and noradrenaline levels were positively correlated with plasma free MN and NMN levels after acute running, respectively. This study revealed that plasma MN and NMN levels transiently increased depending on exercise intensity in amateur runners. In selleck compound , plasma NMN levels are better markers than plasma MN levels because of their stronger correlation with plasma catecholamine levels.This study revealed that plasma MN and NMN levels transiently increased depending on exercise intensity in amateur runners. In addition, plasma NMN levels are better markers than plasma MN levels because of their stronger correlation with plasma catecholamine levels.The study explored fisherfolk's perception and attitude in regard to solid waste disposal and the implications of these for public health, aquatic resources, and sustainable development (SD) in a Ghanaian fishing community. Qualitative data were obtained from 37 purposively targeted participants comprising 34 fisherfolk, an environmental health expert, a water and sanitation expert, and a fisheries and aquatic sciences expert through in-depth interviews and focus group discussions. Data were analysed thematically guided by the most significant stories. While the fisherfolk perceived waste as useless and a nuisance, the experts saw it as a nuisance and/or resource. The fisherfolk did not sort their waste in line with best practices, nor were they willing to pay for waste collection services, citing poverty as the main reason. While most fisherfolk disposed of their waste into bins as approved, others did so onto the street, into the drains, lagoon, and sea. While the fisherfolk were aware that indiscriminate went (SDG) 6 on water, sanitation, and hygiene and SDG 14 regarding sustainable use of the oceans, seas, and marine resources.Artificial sweeteners are posing a new threat to the environment. The water ecosystem is the primary recipient of these emerging contaminants. Once ingested, sufficient amount of these artificial sweeteners escape unchanged from the human body and are added to the environment. However, some are added in the form of their breakdown products through excretion. Artificial sweeteners are resistant to wastewater treatment processes and are therefore continuously introduced into the water environments. However, the environmental behavior, fate, and long-term ecotoxicological contributions of artificial sweeteners in our water resources still remain largely unknown. Some artificial sweeteners like saccharin are used as a food additive in animal feeds. It also forms the degradation product of the sulfonylurea herbicides. All artificial sweeteners enter into the wastewater treatment plants from the industries and households. From the effluents, they finally reside into the receiving environmental bodies including wastewaters, groundwaters, and surface waters. The global production of these sweeteners is several hundred tons annually and is continuously being added into the environment. Thrombocytopenia is the most common hematological abnormality in patients with acute malaria. This study aimed to determine the role of thrombocytopenia as a diagnostic marker for malaria in patients with acute febrile illness. A cross-sectional health facility-based study was conducted on 423 consecutively selected acute febrile patients at Ataye District Hospital from February to May 2019 GC. A complete blood count and malaria microscopy were performed for each acute febrile patient. ROC curve analysis was performed to calculate sensitivity, specificity, positive predictive value, and negative predictive value of platelet count in predicting malaria. A  ≤ 0.05 was considered statistically significant. Out of the 423 acute febrile patients, 73 (17.3%) were microscopically confirmed malaria cases and the rest 350 (82.7%) patients had negative blood film results. Of the microscopically confirmed malaria cases, 55 (75.34%) were and 18 (24.66%) were . The prevalence of thrombocytopenia among malariaTherefore, this may be used in addition to the clinical and microscopic parameters to heighten the suspicion of malaria.Elephantiasis is the main cause of tropical lymphoedema in Ethiopia. The aim of the current study was to assess the etiology of elephantiasis and its associated risk factors. Cross-sectional community-based study was carried out from March to May 2020 in seven purposively selected villages of Jeldu district. Identified suspected cases of elephantiasis in those villages were interviewed, clinically observed, and serologically examined using filariasis test strip kits at their respective houses during day time. A midnight blood sample was obtained from all FTS positive cases for microscopic examination of Wuchereria bancrofti larva, microfilariae. From a total of 105 identified elephantiasis cases, 69.5% were podoconiosis cases and 30.5% were LF cases. Among 32 serologically positive cases, only 15.6% cases were found positive by parasitological blood diagnosis. Considerable cases of podoconiosis (37%) were at age range 26-40 years, whereas smallest cases (16.4%) were at 10-25 years. #link# Among cases of podoconiosis and LF, 77 subjects have been developed overt chronic leg(s) swelling; 85.