Associated benefits and risks as well as the clinical use and availability are all addressed for each therapy. Moreover, future trends in wound care including novel formulations using metallic nanoparticles and topical insulin are herein presented. These novel formulations have shown to be promising therapeutic options in the near future that may change the wound care paradigm.Objective The twenty first century's progress in medicine and cosmetology triggered the search for effective and safe new cosmetics and procedures to fight with such problems as wrinkles or stretch marks. The study aimed to use the synergy of silanols with boron compounds and to develop treatment methods supported by a fractional-ablative laser.Methods Sixty-seven Caucasian people were enrolled in this study 33 patients with facial and neck wrinkles and 34 patients with stretch marks. Preparations containing methylsilanetriol were pressed into the skin by means of oxygen infusion which were followed by the fractional-ablative laser treatments.Results The effectiveness of removal of wrinkles was better if combination therapy was used in the form of transdermal delivery of methylsilanetriol combined with laser therapy. The effectiveness of stretch marks removal by combination therapy was comparable to a two laser treatments and more effective than one laser therapy. Moreover, the use of products based on methylsilanetriol stabilized with boric citrate resulted in shortening the period of regeneration after the treatment with fractional-ablative laser by 29-58%.Conclusion The gel based on methylsilanetriol developed in this study can be successfully used after all laser treatments, but also those related to skin pricking to accelerate regeneration.We have analyzed in a retrospective study of consecutive diabetic patients affected by no-option critical limb ischemia (CLI) the efficacy of the dermal substitute Integra Dermal Regeneration Template for treatment of complicated foot lesions. The primary end point was limb salvage and 1-year amputation-free survival. The secondary end point was healing time of surgical site. Between October 2014 and October 2017, 1024 patients with diabetic foot ulcer (DFU) and CLI were admitted. In 84 patients (8.2%), there was a failure in distal revascularization with a persistent CLI after the procedure. Despite the persistent CLI, a group of 26 patients of this cohort obtained complete wound healing. Barasertib-HQPA Among them, 13 patients were treated with surgical debridement or open amputations and application of dermal substitute Integra Dermal Regeneration Template and the other 13 patients were treated without any dermal substitute. The Integra group healed within a mean time of 83.5 days, and the control group healed within a mean of 139 days (P = .028). No major amputation was carried out at 1-year follow-up in the Integra group versus 15% in the control group. A conservative foot surgery or an approach with minor amputation in diabetic patients with no-option CLI may achieve limb salvage. The use of Integra Dermal Regeneration Template in patients with DFU and no-option CLI may be a useful option in a limb salvage program.Pregnancy and early life create specific psychosomatic challenges for the mother and child, such as changes in hemodynamics, resetting of the water-electrolyte balance, hypoxia, pain, and stress, that all play an important role in the regulation of the release of oxytocin and vasopressin. Both of these hormones regulate the water-electrolyte balance and cardiovascular functions, maturation of the cardiovascular system, and cardiovascular responses to stress. These aspects may be of particular importance in a state of emergency, such as hypertension in the mother or severe heart failure in the child. In this review, we draw attention to a broad spectrum of actions exerted by oxytocin and vasopressin in the pregnant mother and the offspring during early life. To this end, we discuss the following topics 1) regulation of the secretion of oxytocin and vasopressin and expression of their receptors in the pregnant mother and child, 2) direct and indirect effects of oxytocin and vasopressin on the cardiovascular system in the healthy mother and fetus, and 3) positive and negative consequences of altered secretion of oxytocin and vasopressin in the mother with cardiovascular pathology and in the progeny with heart failure. The present survey provides evidence that moderate stimulation of the oxytocin and vasopressin receptors plays a beneficial role in the healthy pregnant mother and fetus; however, under pathophysiological conditions the inappropriate action of these hormones exerts several negative effects on the cardiovascular system of the mother and progeny and may potentially contribute to the pathophysiology of heart failure in early life.Objective The present study had two objectives (1) to investigate differences in voice parameters between teachers with and without self-reported voice disorders and (2) to find differences in voice parameters between teachers and healthcare workers without self-reported voice disorders.Method Three respondents' groups were formed teachers with self-reported voice disorders (mean age, 47 years; range, 34-60 years), teachers without self-reported voice disorders (46; 27-64), and healthcare workers without self-reported voice disorders (45; 31-63). All participants were women. Maximum Phonation Time (MPT), fundamental frequency (F0), jitter, shimmer, frequency and intensity range, Dysphonia Severity Index (DSI), Voice Handicap Index-30 (VHI), and perceived stress (PSS) were assessed in respondents.Results Twenty-nine percent of teachers noted two or more vocal symptoms daily or weekly. Teachers with self-reported voice disorders had a higher degree of perceived stress (18 vs. 13, p = .009), higher score on the VHI (25 vs. 13, p = .001), and lower score on the DSI (2.65 vs. 3.21, p = .037), than teachers without self-reported voice disorders. The VHI-30 score of 15 points could be a cut off value describing voice disorders in female teachers. Differences between teachers and health care workers without self-reported voice disorders were found in MPT (p = .001), F0 (p = .012), jitter (p = .009), DSI (p = .023), and the perceived stress score (p = .041).Conclusions The teaching profession can influence the voice, and the presence of psycho-emotional factors can lead to the development of voice disorders in teachers.