Rheumatoid arthritis (RA) is a common connective tissue disease, characteristic of chronic and invasive synovitis in single or multiple joints and vasculitis. RA is a heterogeneous disease with unclear pathogenesis. Therefore, exploring the etiology and pathogenesis of the disease is essential for identifying new promising treatment strategy for RA. Accumulated data have implicated the significant role of non-coding RNA in RA, some of which are demonstrated to regulate inflammation and autoimmunity in RA through toll-like receptor (TLR) signaling pathway. To clarify the mechanism of non-coding RNA regulating the generation of proinflammatory mediators is helpful for understanding the pathogenesis of RA. Moreover, these well established non-coding RNAs can serve as novel biotargets for RA diagnosis and treatment. Here, we summarize currently available data on non-coding RNAs, TLRs, and the underlying molecular mechanisms in RA. This review will provide insight into the potential use of non-coding RNA as disease diagnosis and treatment markers for RA.Here, we summarize currently available data on non-coding RNAs, TLRs, and the underlying molecular mechanisms in RA. This review will provide insight into the potential use of non-coding RNA as disease diagnosis and treatment markers for RA.Advances in genomics and proteomics aid the identification of genes associated with various diseases. Genomewide association studies (GWAS) have identified multiple loci as risk alleles for susceptibility to rheumatoid arthritis (RA). A bisection of RA risk can be attributed to genetic factors. Over 100 associated genetic loci that encompass immune regulatory factors have been found to be linked with RA. Aberrant single nucleotide polymorphisms (SNPs) and alternative splicing mechanisms in such loci induce RA. These aberrations are viewed as potential therapeutic targets due to their association with multitude of diseases. This review presents few imperious genes whose alterations can cause severe bone deformities culminating in RA. Novel coronavirus pneumonia (NCP), or coronavirus disease 2019 (COVID-19), is a worldwide health threat that has affected millions of people globally. Traditional Chinese medicine (TCM) has been introduced for the treatment of COVID-19. However, efficacy differs among herbal medicines, and the ideal prescription pattern for TCM herbal formulae for COVID-19 treatment needs to be explored. Therefore, the data mining method has been used in this study to analyze the TCM prescription pattern for COVID-19. The aim of this study was to analyze the TCM prescription pattern in Regional Schemes in China for COVID-19 in order to provide a new reference for the use of TCM in COVID-19 treatment. By searching the TCM treatment protocols of COVID-19 in 23 Regional Schemes, TCM syndromes and herbal medicines were analyzed by data mining. The Ancient and Modern Medical Case Cloud Platform (V2.1 personal Edition) was used to perform frequency statistics, correlation analysis, and cluster analysis. A total of 82 TCM syndory effects, maintaining organ function, and improving leukocyte survival. This study may help to improve understanding of TCM herbal prescription pattern, practices, reveal the efficacy of combinations of Chinese herbs, and provide new ideas for TCM treatment for COVID-19.This study may help to improve understanding of TCM herbal prescription pattern, practices, reveal the efficacy of combinations of Chinese herbs, and provide new ideas for TCM treatment for COVID-19. In this work 1,3-oxazoles were generated using multicomponent reaction of α-bromo ketones, alkyl (aryl) isothiocyanates, sodium hydride and Fe3O4 MNPs in water at room temperature in good yields. The nanoparticles that is generated via biosynthesis method have potentially valuable in different purposes such as organic synthesis. To study antioxidant ability of some synthesized thioxo-1,3-oxazoles, diphenyl-picrylhydrazine (DPPH) radical trapping and power of ferric reduction testes are employed. Among studied thioxo-1,3-oxazoles, 4b have good power for radical trapping and reduction activity than to standard antioxidant such as BHT and TBHQ. In addition, the antimicrobial activity of some thioxo-1,3-oxazoles was studied employing the disk diffusion test on Gram-positive bacteria and Gram-negative bacteria. The results of disk diffusion test showed that compound 4a, 4b, 4d and 4f prevented the bacterial growth. Without employing catalyst, these reactions have low yield and busy mixture. The synthesis of compound 4a as sample reaction have alike yield in the presence of ZnO-NPs and Fe3O4 MNPs (entry 20 and entry 30) but removal of catalyst from the mixture of reaction after completing of reaction is comfortable in present of Fe3O4 MNPs. Structures of 4a-4i are confirmed by IR, 1H NMR, 13C NMR mass spectra. The reaction of α-bromo ketones, isothiocyanate and sodium hydride in the presence of catalytic amount of Fe3O4 MNPs in water generate 1,3-oxazole derivatives in good yields. Some advantages of performing these reactions with present procedure are carrying out these reactions in water as green solvent and simple removal of catalyst.The reaction of α-bromo ketones, isothiocyanate and sodium hydride in the presence of catalytic amount of Fe3O4 MNPs in water generate 1,3-oxazole derivatives in good yields. Some advantages of performing these reactions with present procedure are carrying out these reactions in water as green solvent and simple removal of catalyst. Prevention and treatment of chronic inflammatory diseases require effective and low-toxic medicines. Molecular hybridization is an effective strategy to enhance the biological activity of new compounds. Triterpenoid scaffolds are in the focus of attention owing to their anti-inflammatory, antiviral, antiproliferative, and immunomodulatory activities. Odanacatib clinical trial Heteroprostanoids have different pleiotropic effects in acute and chronic inflammatory processes. The study aimed to develop structurally new and low toxic anti-inflammatory agents via hybridization of betulinic acid with azaprostanoic acids. A series of betulinic acid-azaprostanoid hybrids was synthesized. The synthetic pathway included the transformation of betulin via Jones' oxidation into betulonic acid, reductive amination of the latter and coupling obtained by 3β-amino-3-deoxybetulinic acid with the 7- or 13-azaprostanoic acids and their homo analogues. The hybrids 1-9 were investigated in vivo on histamine-, formalin- and concanavalin A-induced mouse paw edema models and two models of pain - the acetic acid-induced abdominal writhing and the hotplate test.