Researchers have tested the effects of low-level light therapy (LLLT) using low-power lasers or non-coherent, non-collimated light therapy from light-emitting diodes (LEDs) on wounds for decades, exploring the efficacy of phototherapy treatments for chronic1 and acute2 wounds. Low-level light therapy has received device clearance in the United States for cosmetic improvement of aging or sun-damaged skin, acne, actinic keratoses, non-melanoma skin cancer, improving circulation, and decreasing pain as well as stiffness and muscle spasm. 3 It has been used for dental, dermatologic, neurologic, and chiropractic conditions in Canada, Europe, and Asia for several years.4 There are few adequately powered, double-blind randomized clinical trials (RCTs) carefully evaluating energy dose-response of each color or wavelength of LLLT. Typical ranges of LLLT include infrared light waves (800-1200 nm, penetrating 5-10 mm of tissue), red (630-700 nm, penetrating 2-3 mm), yellow (570-590 nm, penetrating 0.5-2 mm), and blue to ultraviolet (400-170 nm, penetrating ⟨ 1 mm).3 Low-level light therapy is delivered at various power densities (W/cm2), time durations, and duty cycles, accumulating as energy absorbed over time, called fluence (J/cm2). The variety of wound outcomes in response to differing LLLT parameters used to stimulate various aspects, depths, and types of tissue injury can be confusing. In this installment of Evidence Corner, a systematic review5 of LED effects on dermatologic conditions and wounds and a second on LLLT effects on diabetic foot ulcers (DFUs)1 add clarity to LLLT effects on some aspects of wound management. Clostridial collagenase ointment (CCO) is the only enzymatic agent indicated for debriding chronic dermal ulcers that is approved by the United States Food and Drug Administration. The objective of this study is to estimate health care spending among patients with Stage 3 and Stage 4 pressure injuries (PIs) and patients with diabetic foot ulcers (DFUs) who experienced early (ie, within 30 days of index diagnosis) versus late (31 to 90 days of index diagnosis) initiation of CCO. Patients with PIs and DFUs between January 2007 and March 2017 were identified. One-to-one matched cohorts were used to compare all-cause health care spending and disease-related health care spending between the early initiation and late initiation groups. Compared to the early CCO initiation group, all-cause health care spending for the late CCO initiation group was higher in both patients with PIs and in patients with DFUs within the 12-month follow-up period. Compared to the early CCO initiation group, disease-related health care spending for the late CCO initiation group was higher in both patients with PIs and in patients with DFUs within the 12-month follow-up period. All computations were statistically significant. Early initiation of CCO provides both all-cause and disease-related health care savings to payers and persons managing patients with PIs or DFUs. Payers, providers, and facilities should consider mechanisms to encourage the early use of CCO to lower costs.Early initiation of CCO provides both all-cause and disease-related health care savings to payers and persons managing patients with PIs or DFUs. Payers, providers, and facilities should consider mechanisms to encourage the early use of CCO to lower costs. Soft tissue infections (STIs), which include infections of the skin, subcutaneous tissue, fascia, and muscle, encompass a wide variety of heterogeneous pathologies. Treatment of STIs is based on surgical debridement of the affected area. One such treatment, negative pressure wound therapy (NPWT), has improved the management of STIs. The purpose of this study is to assess the safety and utility of NPWT in conjunction with dermatotraction in the early stage management of necrotizing STIs. The authors report a retrospective series of 3 cases in which NPWT and dermatotraction (NPWT-D) were used in an attempt to manage necrotizing STI. Tetramisole nmr The NPWT-D device combination was employed to approximate the edges of the wounds. The NPWT device was changed every 2 or 3 days, and dermatotraction tension was adjusted concurrently. The NPWT-D device changes ranged from 3 to 4 times for 2 of the 3 patients, as 1 patient passed away secondary to STIs and therefore did not receive complete treatment. The total treatment ranged from 8 to 10 days in the remaining 2 patients. In both cases, complete wound closure was achieved while avoiding skin grafts. After 5 days of therapy in the incomplete treatment case, the wound area was reduced by about half. Based on the experiences herein, NPWT-D may be a safe and useful alternative surgical treatment for the management of necrotizing STIs. In the present cases, NPWT-D improved and shortened the wound healing process, and it achieved a tertiary wound closure, thereby avoiding the need for skin grafts.Based on the experiences herein, NPWT-D may be a safe and useful alternative surgical treatment for the management of necrotizing STIs. In the present cases, NPWT-D improved and shortened the wound healing process, and it achieved a tertiary wound closure, thereby avoiding the need for skin grafts.[This corrects the article DOI 10.2196/17595.].[This corrects the article DOI 10.2196/22388.].Detection and localization of terminations and junctions is a key step in the morphological reconstruction of tree-like structures in images. Previously, a ray-shooting model was proposed to detect termination points automatically. In this paper, we propose an automatic method for 3D junction points detection in biomedical images, relying on a circular sampling model and a 2D-to-3D reverse mapping approach. First, the existing ray-shooting model is improved to a circular sampling model to extract the pixel intensity distribution feature across the potential branches around the point of interest. The computation cost can be reduced dramatically compared to the existing ray-shooting model. Then, the Density-Based Spatial Clustering of Applications with Noise (DBSCAN) algorithm is employed to detect 2D junction points in maximum intensity projections (MIPs) of sub-volume images in a given 3D image, by determining the number of branches in the candidate junction region. Further, a 2D-to-3D reverse mapping approach is used to map these detected 2D junction points in MIPs to the 3D junction points in the original 3D images.