inicalTrials.gov number, NCT02584283.).Hypothermic oxygenated machine perfusion led to a lower risk of nonanastomotic biliary strictures following the transplantation of livers obtained from donors after circulatory death than conventional static cold storage. (Funded by Fonds NutsOhra; DHOPE-DCD ClinicalTrials.gov number, NCT02584283.).Since the first report on it in December 2019 in Wuhan, China, the novel coronavirus disease 2019 (COVID-19) has rapidly spread throughout the world. Due to the lack of effective therapy available for COVID-19 patients, the identification of risk factors for the severe course of the disease is a matter of urgency. Therefore, the aim of this review was to report on evidence-based risk factors affecting the severity and prognosis of COVID-19. We searched the PubMed database for current literature to identify relevant publications concerning risk factors for COVID-19 severity. Demographic and social factors (age, gender, race, in-center communities/nursing homes), clinical factors (smoking, hypertension, obesity, diabetes, chronic lung diseases, cardiovascular diseases - CVD, chronic kidney disease - CKD, malignancies, dementia, cardiomyopathies, immunocompromised state), laboratory markers (C-reactive protein - CRP, leukocytosis, ferritin, interleukin (IL)-6, D-dimer, lactate dehydrogenase - LDH, aspartate aminotransferase - AST, procalcitonin, creatinine, lymphopenia, IL-2, IL-7, IL-10, granulocyte colony-stimulating factor - G-CSF, also known as colony-stimulating factor 3 - CSF 3, interferon gamma-inducible protein-10 - IP-10, monocyte chemoattractant protein-1 - MCP-1, macrophage inflammatory protein-1alpha - MIP1A, tumor necrosis factor alpha - TNF-α), and genetic factors related to both the virus and the host were discussed. The identification of the potential risk factors affecting the severity and prognosis of COVID-19 may provide a chance for earlier and more effective management of COVID-19. This study aimed to describe and visualize the current research state and collaborative networks in home care safety for older adults over the past 11years to analyse the gaps of research and future research trends. The amount of research on safety in home care for older adults is increasing. It is necessary to understand the status of development and main research topics and identify the main contributors and their relationships. A total of 2,631 publications were retrieved from the Web of Science. The external characteristics of the publications were summarized with the Web of Science and Histcite. LY364947 Collaborative networks and keywords were analysed and visually displayed using analysis tools. The number of articles increased over the years. Articles were identified from 79 countries, 3,630 institutions, 647 journals and 11,691 authors, and complex cooperative relations among them and five research topics were identified. Research on home care safety for older adults is developing steadily, and this field may be understood to a greater extent in the future. Countries, institutions and scholars need to cooperate more in this research field. This study contributes important information for understanding achievements in the research field of home care safety and provides insights into future research.This study contributes important information for understanding achievements in the research field of home care safety and provides insights into future research.One of the hallmarks of aging is an accumulation of cells with defects in oxidative phosphorylation (OXPHOS) due to mutations of mitochondrial DNA (mtDNA). Rapidly dividing tissues maintained by stem cells, such as the colonic epithelium, are particularly susceptible to accumulation of OXPHOS defects over time; however, the effects on the stem cells are unknown. We have crossed a mouse model in which intestinal stem cells are labelled with EGFP (Lgr5-EGFP-IRES-creERT2) with a model of accelerated mtDNA mutagenesis (PolgAmut/mut ) to investigate the effect of OXPHOS dysfunction on colonic stem cell proliferation. We show that a reduction in complex I protein levels is associated with an increased rate of stem cell cycle re-entry. These changes in stem cell homeostasis could have significant implications for age-associated intestinal pathogenesis. The aim of the study was to explore the experiences of homecare staff about the impact of the organization of homecare services for people with dementia. This study has a qualitative, exploratory design based on a phenomenological-hermeneutic approach, using individual in-depth interviews with homecare staff to collect data. A convenience sample of 14 homecare staff from five municipalities participated in the study. Main topics introduced (a) how homecare services for people with dementia are organized and (b) challenges in respondents' everyday practice of caring for people with dementia. Interviews were conducted from October to December 2017. Three main themes were identified from the interviews. (a) Complexity and need for individualized facilitated homecare services; homecare services were described as complex in regard to both the patient and the service. The complexity of the service made it challenging to tailor the service to the individual patient. (b) The importance of trust and relationshn the organization. Practical tasks and following the daily scheduled task list were often prioritized at the expense of an individually tailored service.Chronic obstructive pulmonary disease (COPD) is characterized by persistent airway inflammation and fixed airflow obstruction. Patients with COPD have increased risk of lung cancer (LC), and the coexistence of both diseases is associated with poorer survival. However, the mechanisms predisposing patients with COPD to LC development and poor prognosis remain unclear. Gene expression profiles were downloaded from the Gene Expression Omnibus. Twenty-two data sets were included (n = 876). We identified 133 DEGs and 145 DEGs in patients with COPD and LC compared with healthy controls, respectively. There were 1544 DEGs in patients with LC and coexisting COPD compared with COPD, and these DEGs are mainly involved in the cell cycle, DNA replication, p53 signalling and insulin signalling. The biological processes primarily associated with these DEGs are oxidation reduction and apoptosis. SPP1 was the only overlapping DEG that was up-regulated in patients with COPD and/or LC, and this was validated by qPCR in an independent cohort.