Network analysis showed how various forms of worry, avoidance, coping, and other variables are interrelated. Implications for managing disease and distress are discussed.Network analysis showed how various forms of worry, avoidance, coping, and other variables are interrelated. Implications for managing disease and distress are discussed.Cognitive Processing Therapy (CPT) and Behavioural Activation Therapy (BA) were used to treat individuals with comorbid posttraumatic stress disorder (PTSD) and major depressive disorder (MDD). Fifty-two individuals (48 women, 4 men) were randomized to CPT alone (n = 18), CPT then BA for MDD (n = 17), or BA then CPT (n = 17). Presenting trauma was primarily interpersonal (87 %). Participants were assessed at pre-, posttreatment, and 6-month follow-up. PTSD and MDD symptoms were the main outcome of interest; trauma cognitions, rumination, and emotional numbing were secondary outcomes. All groups showed sizeable reductions in PTSD and depression (effect sizes at follow-up ranging between 1.02-2.54). A pattern of findings indicated CPT/BA showed better outcomes in terms of larger effect sizes and loss of diagnoses relative to CPT alone and BA/CPT. At follow-up greater numbers of the CPT/BA group were estimated to have achieved good end-state for remission of both PTSD and depression (49 %, CI95 [.26, .73]) relative to CPT alone (18 %, CI95 [.03, .38]) and BA/CPT (11 %, CI95 [.01, .29]). Although tempered by the modest sample size, the findings suggest that individuals with comorbid PTSD and MDD may benefit from having PTSD targeted first before remaining MDD symptoms are addressed. Curcumin is a biologically active phytochemical ingredient found in turmeric. It has several pharmacologic effects that might benefit patients with polycystic ovary syndrome (PCOS). We hypothesized curcumin to be effective in improving blood sugar levels, insulin resistance and hyperandrogenism in individuals with PCOS. In a randomized double-blind placebo-controlled trial, individuals with PCOS were treated with curcumin (500mg three times daily) or placebo for 12 weeks. Primary outcome measures were fasting plasma glucose (FPG), fasting insulin (FI), sex hormone levels, and hirsutism (Ferriman-Gallwey [mFG] score). Secondary outcomes included anthropometric measurements. Of 72 randomized individuals, 67 completed the trial. The two groups were comparable at baseline. At the end of the study, FPG and Dehydroepiandrosterone levels had decreased significantly in the intervention group compared to control (difference of change (post-pre) between intervention and placebo groups -4.11mg/dL; 95% CI -8.35, -0.35mg/dL; p=0.033 and -26.53 microg/dL; 95% CI -47.99, -4.34µg/dL; p=0.035, respectively). We also observed a statistically non-significant increase (p=0.082) in Estradiol levels in the intervention group compared to control. No serious adverse events were reported throughout the trial. Curcumin might be a safe and useful supplement to ameliorate PCOS-associated hyperandrogenemia and hyperglycemia. However, longer trials investigating different dosages in longer durations are needed to underpin these findings.Curcumin might be a safe and useful supplement to ameliorate PCOS-associated hyperandrogenemia and hyperglycemia. However, longer trials investigating different dosages in longer durations are needed to underpin these findings.Despite the idealization of thin bodies, many people with low body weights report experiencing weight stigma. This stigma might relate to stereotypes about eating disorders (EDs). Specifically, people with lower body weights might be perceived as having EDs, conditions associated with significant stigma. Also, there is considerable pressure for Black women to obtain a curvy ideal, which could lead to anti-thin bias (i.e., the belief that individuals at lower body weights have undesirable characteristics) in this group. The current study evaluated these possibilities via an examination of anti-thin bias in Black and White women. Further, we explored perceived attributions of weight for Black and White women with underweight. selleck chemicals llc Black (n = 96) and White (n = 128) participants read racially concordant vignettes in which characters varied by body mass index (BMI) status (slightly underweight, average weight, and slightly overweight). White women were more likely to ascribe negative personality characteristics to White vignette characters with underweight than to characters with average weight. In contrast, Black women's perceptions of Black vignette characters did not differ according to weight status. Both Black and White participants were more likely to attribute underweight characters' body weight to an ED compared with average weight characters. Results suggest that weight bias literature should incorporate the assessment and impact of weight stigma for individuals across the BMI spectrum.Shallow coastal zones may provide cross-habitat nutrient subsidies for benthic communities offshore, as macrophyte matter can drift to deeper sediments. To study the relative importance of carbon and nutrient flows derived from different primary food sources in a coastal ecosystem, the diets of clam Macoma balthica, polychaete Marenzelleria spp. and mussel Mytilus trossulus were examined across environmental gradients in the northern Baltic Sea using a triple-isotope approach (i.e. 13C, 15N and 34S) and Bayesian mixing models (MixSIAR). Our results suggest that in shallow habitats, production from Fucus vesiculosus is the primary energy source for M. balthica. The proportion of macroalgae-derived matter in the diet of M. balthica and Marenzelleria spp. decreased following a depth gradient. Our models for M. trossulus indicate that the pelagic POM dominates its diet. Our results indicate a trophic connectivity between shallow macrophyte-dominated and deeper habitats, which receive significant amounts of nutrient subsidies from shallower areas.We examined trophic relationships in estuarine planktonic food webs by focusing on the assemblages and functional groups of copepods and their effects on prey and predator. We also studied the relationship between biodiversity and ecosystem functioning in estuaries using different taxonomic and functional diversity indices of copepod assemblages and copepod biomass as a proxy of ecosystem functioning. We collected samples every 2 months over a 2-year period in four Brazilian estuaries. Taxonomic diversity indices showed a positive and negative relationship with chaetognath densities and ecosystem functioning, respectively. The functional indices were negatively related to the effect of predator diversity on prey. Different functional groups of copepods were positively correlated with chaetognath density, consistent with their generalist feeding habits. Thus, multifaceted approaches that use different indices and functional groups are recommended to provide a more realistic view of the trophic relationships and ecosystem functioning in estuaries.