These results suggest that ASB8, NOL8, and CDR2 were target genes of MIR452 in CRC cells and that up-regulated MIR452 in CRC tissue regulated ASB8, NOL8, and CDR2 expression during colorectal carcinogenesis.The analytical expression for the Voigt profile, along with its simplified forms for the Gaussian and Lorentzian dominance, is presented. The applicability of the Voigt profile in the description of anomalous diffusion phenomena, ubiquitous in different fields of science including protein folding, is discussed. It is shown that the Voigt profile is a good descriptor of the processes occurring in protein folding and in the native state. The usefulness of the Voigt profile in deriving important information of the diffusive motions in proteins from a quasielastic incoherent neutron scattering experiments is illustrated. Oncologic outcomes after complete mesocolic excision (CME) in colon cancer are under investigation. The aim of our study was to compare CME and conventional colectomy (CC) in terms of pathological and oncological outcomes for right colon cancer and to evaluate the impact of lymph node metastasis around the vascular tie on survival. Consecutive patients with right colon cancer who had CME or CC between January 2011 and August 2018 at two specialized centers in Turkey were included. Statistical analyses were performed with respect to demographic characteristics, operative and pathologic outcomes, harvested and metastatic lymph nodes around the vascular tie (LNVT), recurrences, and survival. There were 91 patients in the CME group (58 males, mean age 64 ± 16years) and 192 patients in the CC group (96 males, mean age 66 ± 14years). The mean number of harvested lymph nodes (CME 42 ± 15 vs CC 34 ± 13, p = 0.01) and LNVT were higher in the CME group (CME 3.2 ± 2.2 vs CC 2.4 ± 1.6, p = 0.001). LNVT metastases were 7.7% and 8.3% in the CME and CC groups, respectively (p = 0.85). Three-year overall and disease-free survival rates were 96.4% and 90.9% in the CME group and 90.4% and 87.6% in the CC group in stage I-III patients (p > 0.05). In stage III patients, the 3-year overall survival (92.5% vs 63.5%, p = 0.03) and disease-free survival (85.6% vs 52.1%, p = 0.008) were significantly better in LNVT-negative patients than in LNVT-positive patients. LNVT metastasis seems to be the key factor associated with poor disease-free and overall survival in right colon cancer regardless of the radicality of surgery.LNVT metastasis seems to be the key factor associated with poor disease-free and overall survival in right colon cancer regardless of the radicality of surgery.Bilinguals' observed perceptual shift across language contexts for shared acoustic properties between their languages supports the idea that bilinguals, but not monolinguals, develop two phonemic representations for the same acoustic property. This phenomenon is known as the double phonemic boundary. This investigation replicated previous findings of bilinguals' double phonemic boundary across a series of go/no-go tasks while controlling for known confounding effects in speech perception (i.e., contrast effects) and differences in resource allocation between bilinguals and monolinguals (i.e., left-hand or right-hand response). Using a range-base language cueing approach, we designed 2 experiments. The first experiment tested whether a voice onset time (VOT) range representative of either Spanish or English phonetic categories can cue bilinguals, but not monolinguals, to use language-specific perceptual routines. The second experiment tested a VOT range with a mixture of Spanish and English phonetic categories to determine whether directing attention to a specific phonetic category can disambiguate the competition of the nonattended category. The results for Experiment 1 showed that bilinguals can rely on the distributional patterns of their native phonetic categories to activate specific language modes. Experiment 2 showed that attention can change the weight given to a native phonetic distinction. However, this process is restricted by the internal phonetic composition of the native language(s).A fundamental problem in speech perception is how (or whether) listeners accommodate variability in the way talkers produce speech. One view of the way listeners cope with this variability is that talker differences are normalized - a mapping between talker-specific characteristics and phonetic categories is computed such that speech is recognized in the context of the talker's vocal characteristics. learn more Consistent with this view, listeners process speech more slowly when the talker changes randomly than when the talker remains constant. An alternative view is that speech perception is based on talker-specific auditory exemplars in memory clustered around linguistic categories that allow talker-independent perception. Consistent with this view, listeners become more efficient at talker-specific phonetic processing after voice identification training. We asked whether phonetic efficiency would increase with talker familiarity by testing listeners with extremely familiar talkers (family members), newly familiar talkers (based on laboratory training), and unfamiliar talkers. We also asked whether familiarity would reduce the need for normalization. As predicted, phonetic efficiency (word recognition in noise) increased with familiarity (unfamiliar less then trained-on less then family). However, we observed a constant processing cost for talker changes even for pairs of family members. We discuss how normalization and exemplar theories might account for these results, and constraints the results impose on theoretical accounts of phonetic constancy.We used a form of ambiguous apparent motion known as Ternus motion to isolate the effects of object-based and space-based attention, and to explore functional differences between them. Two frames of horizontally aligned disks that were shifted by one position between frames were temporally separated by either a short or a long inter-stimulus interval (ISI). Short ISI displays were perceived as element motion where one disk appeared to jump across the other two. Long ISI displays were perceived as group motion where all three disks appeared to move together. Because element and group motion imply mutually exclusive object structures, adding stimuli (e.g., a small gap) to one disk in each frame created conditions of orthogonal object and location status (same or different), depending on ISI. We used two tasks with different functional demands, an identification task (Experiments 1 and 3a) in which observers responded to a single attribute of the final stimulus, and a comparison task (Experiments 2 and 3b) in which observers compared two attributes across two stimuli.