The frequency of treatment-related grade 3-4 adverse events was similar between treatment arms 48% vs 43% for the combination and paclitaxel arms, respectively. ORR in the EP-100 combination arm was similar to that in the group treated with paclitaxel alone; however, a subset of patients with liver metastases appeared to benefit from the combination. The addition of EP-100 did not appear to augment the adverse event profile of paclitaxel and was well tolerated.ORR in the EP-100 combination arm was similar to that in the group treated with paclitaxel alone; however, a subset of patients with liver metastases appeared to benefit from the combination. The addition of EP-100 did not appear to augment the adverse event profile of paclitaxel and was well tolerated. To assess whether the number of practice sites per gynecologic oncologist (GO) and geographic access to GOs has changed over time. This is a retrospective repeated cross-sectional study using the 2015-2019 Physician Compare National File. All GOs in the 50 United States and Washington, DC, who had completed at least one year of practice were included in the study. All practice sites with complete addresses were included. RGD peptide clinical trial Linear regression analyses estimated trends in GOs' number of practice sites and geographic dispersion of practice sites. Secondary analyses assessed temporal trends in the number of geographic areas served by at least one GO. Although there was no significant change in the number of GOs from 2015 to 2019 (n=1328), there was a significant increase in the number of practice sites (881 to 1416, p=0.03), zip codes (642 to 984, p=0.03), HSAs (404 to 536, p=0.04), and HRRs (218 to 230, p=0.03) containing a GO practice. The mean number of practice sites (1.64 versus 2.13, p<0.001) and dispersion of practice sites (0.03 versus 0.43miles, p=0.049) per GO increased significantly. Between 2015 and 2019, an increasing number of GOs have multi-site practices, and more geographic regions contain a GO practice. Improvements in geographic access to GOs may represent improved access to care for many women in the US, but its effect on patients, physicians, and geographic disparities is unknown.Between 2015 and 2019, an increasing number of GOs have multi-site practices, and more geographic regions contain a GO practice. Improvements in geographic access to GOs may represent improved access to care for many women in the US, but its effect on patients, physicians, and geographic disparities is unknown.Quantifying the occurrence of Antarctic antibiotic-resistant bacteria (ARB) is essential for assessing the level of pollution and assessing the "baseline" or background level of ARB in human uninhabited environments. Animal feces, soil, and sediments were sampled from Fildes Peninsula. The abundance of sulfamethazine- and ciprofloxacin-resistance bacteria and antibotic resistance genes (ARGs) within ARB were investigated. The results showed Ciprofloxacin- and Sulfamethazine-resistant bacteria isolated from samples accounted for the highest abundances of 30 CFU/g and 79.8 CFU/g, respectively. The dominant genus of Sulfamethazine-and quinolone-resistance bacteria was Pseudomonas and Arthrobacter, respectively. 106 ARGs were detected from ARB. Strong positive correlations between mobile genetic elements (MGEs) and ARGs were found, what is relatively novel observation that the mechanism is confirmed to also occur in the Antarctic. This study reveals the compositional characteristics of ARGs of strains in Antarctic, providing support for the source of Antarctic antibiotic resistance and drug resistance mechanisms.Since December 2019, an outbreak of coronavirus disease 2019 (COVID-19) which initially occurred in the city of Wuhan, located in China's Hubei province, spread around the world and on March 11, 2020, the World Health Organization declared the new Coronavirus disease 2019 (COVID-19) as a pandemic. The presence of comorbidities (eg, cardiovascular disease, obesity), Sepsis Induced Coagulopathy score >4, elevation of D-dimer (>6 times the normal value), C-reactive protein, troponins and other disseminated intravascular coagulation markers; is associated to a worse prognosis in hospitalized patients with severe COVD-19, reaching a hospital mortality of 42%. Initial anticoagulant treatment with low molecular weight heparin has been shown to reduce mortality by 48% at 7 days and 37% at 28 days and achieve a significant improvement in the arterial oxygen pressure/inspired fraction of O2 (PaO2/FiO2) by mitigating the formation of microthrombi and associated pulmonary coagulopathy. To determine the effect of organosilane content on the physicochemical properties of model composites formulated with nano-sized fillers. Model composites were formulated with dimethacrylate-based monomers, a photoinitiator/co-initiator system and silicon dioxide nano-sized fillers treated with different amounts of 3-methacryloxypropyltrimethoxysilane (MPTS) 1.0 (G ), 2.0 (G ), 5.0 (G ), 7.5 (G ) and 10 (G ) wt.% relative to SiO . Non-silanized fillers (G ) were used in the control group. Degree of conversion (DC) was assessed by Fourier-transformed infrared spectroscopy (ATR-FTIR). Knoop hardness (KHN) and elastic modulus were determined before and after water storage for 4 months. Water sorption (Wsp) and solubility (Wsl) were calculated by successive mass determinations in analytical balance. Surface gloss and roughness were characterized before and after toothbrushing simulation. With the exception of those fillers treated with 1% MPTS, DC was not dependent on the silane content. Within the s nano-filled composites. Therefore, 2 wt.% of silane was the optimized quantity to produce materials resistant to degradation, both in bulk and surface properties. Formulate experimental adhesives containing titanium dioxide nanotubes (nt-TiO ) or titanium dioxide nanotubes with a triazine-methacrylate monomer (nt-TiO TAT) and evaluate the effect of these fillers on the physical, chemical, and biological properties of the adhesives. First, nt-TiO were synthesized via a hydrothermal method. The nt-TiO were mixed with a triazine-methacrylate monomer (TAT) to formulate nt-TiO TAT, which were characterized by transmission electron microscopy (TEM). The nt-TiO , TAT, and nt-TiO TAT were evaluated via Fourier Transform Infrared, Ultraviolet-visible, and micro-Raman spectroscopies. An experimental adhesive resin was formulated with bisphenol A glycerolate dimethacrylates, 2-hydroxyethyl methacrylate, and photoinitiator/co-initiator system. nt-TiO or nt-TiO TAT were incorporated at 2.5 wt.% and 5 wt.% in the adhesive. The base resin without nt-TiO or nt-TiO TAT was used as a control group. The adhesives were evaluated for antibacterial activity, cytotoxicity, polymerization kinetics, degree of conversion (DC), Knoop hardness, softening in solvent (ΔKHN%), ultimate tensile strength (UTS), 24 h- and 1 year- microtensile bond strength (μ-TBS).