Significant positive correlations between IGF-I concentrations and BMD obtained from both REMS and DXA were detected in the AG and WCA. In the AG and WCA, there were positive correlations between T-scores and LS BMD obtained from both methods. Radiofrequency echographic multi-spectrometry is a potential method in assessment of bone status in acromegaly. Further studies with participation of active disease patients are needed.Radiofrequency echographic multi-spectrometry is a potential method in assessment of bone status in acromegaly. Further studies with participation of active disease patients are needed. Asprosin is a hormone that was first discovered in 2016 by Romere et al. Its secretion is induced in case of starvation. Asprosin promotes hepatic glucose release. There is no literature information available in humans to demonstrate how blood and saliva asprosin levels of patients with newly diagnosed T2DM changed after metformin treatment. We aim to examine these changes and contribute to the literature in this sense. A total of 60 individuals, 30 healthy volunteers, and 30 newly diagnosed cases of T2DM, whose treatment was initiated, were included in the study. Saliva and blood samples were collected from both groups. Serum and saliva asprosin levels were measured by the ELISA method. Asprosin synthesis sites of salivary gland tissues were determined immunohistochemically. When the healthy control group and the newly diagnosed T2DM group were compared in terms of plasma asprosin levels and it was found that the asprosin levels were higher in the newly diagnosed T2DM group (P = 0.003). In terms of saling diabetes development and that this hormone can be considered as a target molecule in the treatment of diabetes. Cortisol concentration is measured in blood, urine, and saliva samples. It has been recently proven that cortisol could also be detected in hair samples. Cortisol measurements in different samples have their own individual characteristics and clinical utility. We aimed to investigate the correlation between hair cortisol concentration and standard cortisol measurements used in clinical practice. Fifty adult volunteers with a negative history of endocrine disorders were enrolled in the study. Morning serum cortisol (MSC), evening serum cortisol (ESC), evening free salivary cortisol (EFSC), urine free cortisol (UFC), and hair cortisol concentration (HCC) were analysed in all participants. Eventually, 41 volunteers were included into the study, whose cortisol concentration in the 1 mg overnight dexamethasone suppression test (1 mg ONDST) were < 50 nmol/L, and cortisol levels in serum, saliva, and urine were within reference ranges. Hair cortisol concentration test was performed for 20 mg of hair strands of the proximal 1 cm hair segments. Hair cortisol concentration ranged from 0.3036 to 2.65 nmol/mg, and the average value was 0.8125 ± 0.4834 nmol/mg. No significant correlations were found between HCC and MSC (rho = 0.04419, p = 0.7838), HCC and ESC (rho = -0.2071, p = 0.1938), HCC and EFSC (rho = 0.1005, p = 0.532), or HCC and UFC (rho = 0.1793, p = 0.262). This work is another step in the discussion on the application of HCC determinations in clinical practice. Our results have showed no correlations between HCC and single point cortisol assessment in blood, saliva, and urine in patients with reference cortisol levels.This work is another step in the discussion on the application of HCC determinations in clinical practice. Our results have showed no correlations between HCC and single point cortisol assessment in blood, saliva, and urine in patients with reference cortisol levels.Hemostasis plays a central role throughout neurosurgery. In microneurosurgery, a bloodless operating field under an operating microscope allows fast and effective surgery, thereby reducing the risk of postoperative hemorrhage. Apart from mechanical methods, such as positioning of the patient's head and body, bone plugging, suction, and metal clips, neurosurgical hemostasis is achieved mainly with bipolar coagulation, which permits optimal control of hemorrhage, allows for fine coagulation of small vessels and is safe in patients with pacemakers and defibrillators. Gelatin sponge is a non-antigenic protein that can absorb 45 times its weight in blood, and, when wet, is plastered to the irregularities of the bleeding surface. It enables the repair of torn veins, such as the superior sagittal sinus, without compromising the patency of the vessel. Surgicel® (Johnson & Johnson, New Brunswick, NJ), the first oxidized cellulose to be introduced, is used to control capillary, venous, or smaller arterial bleeding because it acts as a matrix for the formation of a clot. Over the past few decades, research on the development of hemostatic agents has shifted to the use of fibrin sealants and flowable agents such as Tisseel Fibrin Sealant® (Baxter, Deerfield, IL), Evicel Fibrin Sealant® (Ethicon, Somerville, NJ) and FloSeal® (Baxter). Very recently, advanced hemostats with sealant properties similar to those of fibrin sealants have been introduced, such as Tachosil® (Baxter, Deerfield, IL) and Hemopatch Sealing Hemostat® (Baxter). Due to the different properties of these products it is important that we understand the efficacy of each hemostatic agent in different neurosurgical settings, such as in the control of parenchymal, subdural and epidural bleeding in both cranial and spinal surgery. Dibenzazepine The aim of this work was to review the principal technical aspects of hemostatic agents to optimize their use in different neurosurgical procedures.The risk of recurrent mitral regurgitation after surgical mitral valve repair for ischemic functional mitral regurgitation is 28 % at 10 years. Also, an increasing number of patients with degenerated mitral bioprostheses are seen in daily clinical practice due to a dramatic shift from mechanical to biological bioprostheses over the past few decades. Therefore, it can be anticipated that there will be growing need for therapy options to treat high-risk patients in case of recurrent mitral regurgitation subsequent to surgical mitral valve repair or replacement. Interventional therapy for failing surgical mitral valve replacement and repair is an appealing option in patients who are ineligible for redo surgery. The efficacy and safety of transcatheter mitral valve replacement have been reported in patients with failing mitral rings or degenerated mitral bioprostheses. However, crucial limitations remain, including possible device malpositioning, left ventricular outflow tract obstruction and postprocedural mitral regurgitation.