Antibody-functionalized targeted nanocarriers to deliver chemotherapeutics have been widely explored. However, it remains highly desirable to understand and apply the antitumor potential of antibodies integrated in hybrid composite nanoplatforms. Herein, mesoporous silica nanoparticles, a supported lipid bilayer and cetuximab were integrated to fabricate a hybrid nanoplatform for effectively encapsulating and selectively delivering 5-fluorouracil (5-FU) against colorectal cancer (CRC) cells. The specially designed nanoplatform exhibited superior properties, such as satisfying size distribution, dispersity and stability, drug encapsulation, controlled release, and cellular uptake. Interestingly, the modification of cetuximab onto nanoplatforms without drug loading can significantly inhibit the migration and invasion of CRC cells through suppressing the epidermal growth factor receptor (EGFR)-associated signaling pathway. Furthermore, delivery of 5-FU by using this nanoplatform can remarkably induce cytotoxicity, cell cycle arrest, and cell apoptosis for CRC cells with high EGFR expression. Overall, this nanostructured platform can dramatically improve the tumor killing effects of encapsulated chemotherapeutics and present antimigration effects derived from the antibody modified on it. Moreover, in vivo biodistribution experiments demonstrated the superior tumor targeting ability of the targeted nanoparticles. Thus, this targeted nanoplatform has substantial potential in combinational therapy of antibodies and chemotherapy agents against colorectal cancer.Bismuth sulfide quantum dots (Bi2S3 QDs), which have excellent optical and thermoelectric properties, represent a green and non-toxic semiconductor material that has been widely used in catalysis and photoelectric conversion devices. At present, research on this material has gradually expanded into the biological field. Herein, the biomineralization method mediated by bovine serum albumin (BSA) was utilized to synthesize Bi2S3 QDs with monodispersity, excellent colloidal stability, and good biocompatibility. This is the first study on the electrochemiluminescence (ECL) characteristics of Bi2S3 QDs and related ECL mechanisms in detail. In addition, on the basis of Bi2S3 QDs, an ECL immunosensor was used for the ultrasensitive measurement of cyclin D1 (CCND1). The composite material, namely Au@Cu-Bi2S3 QDs was used as a high-sensitivity ECL probe, in which AuNPs were connected with Bi2S3 QDs through a copper(ii) ion bridge. PDA-AgNPs made of dopamine (DA) and silver nanoparticles (AgNPs) were utilized as a carrier for fixing the primary antibody (Ab1), ultimately presenting a relatively wide detection range of 10 fg mL-1-1 μg mL-1. Cyclopamine Moreover, quite a low detection limit (6.34 fg mL-1) was also obtained for an assay of CCND1. Results indicated that the immunosensor can provide a potential platform with fine stability and creditable reproducibility for clinical diagnosis.The design of molecular phosphors with near-unity photoluminescence quantum yields in the low-energy regions of the spectrum, red to near-infrared, is a long-standing challenge. Because of the energy gap law and the quantum mechanical dependence of radiative decay rate on the excited-state energy, compounds which luminesce in this region of the spectrum typically suffer from low quantum yields. In this article, we highlight our group's advances in the design of top-performing cyclometalated iridium complexes which phosphoresce in red to near-infrared regions. The compounds we have introduced in this body of work have the general formula Ir(C^N)2(L^X), where C^N is a cyclometalating ligand that controls the photoluminescence color and L^X is a monoanionic chelating ancillary ligand. The Ir(C^N)2(L^X) structure type is among the most widely studied and technologically successful classes of molecular phosphors, particularly when L^X = acetylacetonate (acac). In our work we have pioneered the use of electron-rich, nitrogen containing ancillary (L^X) ligands as a means of controlling the excited-state dynamics and optimizing them to give record-breaking phosphorescence quantum yields. This paper progresses through our work in three distinct regions of the spectrum - red, deep-red, and near-infrared - and summarizes the many insights we have gained on the relationships between molecular structure, frontier orbital energies, and excited-state dynamics.Recent advances in immunotherapy have highlighted a need for therapeutics that initiate immunogenic cell death in tumors to stimulate the body's immune response to cancer. This study examines whether laser-generated bubbles surrounding nanoparticles ("nanobubbles") induce an immunogenic response for cancer treatment. A single nanosecond laser pulse at 1064 nm generates micron-sized bubbles surrounding gold nanorods in the cytoplasm of breast cancer cells. Cell death occurred in cells treated with nanorods and irradiated, but not in cells with irradiation treatment alone. Cells treated with nanorods and irradiation had increased damage-associated molecular patterns (DAMPs), including increased expression of chaperone proteins human high mobility group box 1 (HMGB1), adenosine triphosphate (ATP), and heat shock protein 70 (HSP70). This enhanced expression of DAMPs led to the activation of dendritic cells. Overall, this treatment approach is a rapid and highly specific method to eradicate tumor cells with simultaneous immunogenic cell death signaling, showing potential as a combination strategy for immunotherapy.A series of nitrogen-rich nitronyl nitroxide radical PPNIT (1)-based (PPNIT = 2-(1-(pyrazin-2-yl)-1H-pyrazole)-4,4,5,5-tetramethyl-imidazoline-1-oxyl-3-oxide) 3d-4f ring-shaped tetranuclear clusters [Ln2Cu2(hfac)10(PPNIT)2(H2O)2]·CHCl3 (LnIII = Gd 2, Tb 3, Dy 4; hfac = hexafiuoroacetylacetonate) with multifunctional properties were isolated. The magnetic behavior, luminescence and heat capacity of the 3d-4f complexes were investigated, displaying interesting multiple properties of the molecular materials. The Gd derivative shows a magnetocaloric effect with the maximum entropy change (-ΔSm) of 15.3 J kg-1 K-1 at 2 K for ΔH = 70 kOe. The Tb cluster exhibits spin glass behavior and the characteristic fluorescence emission of the TbIII ion, while the Dy cluster exhibits SMM behaviour, and the heat capacity has been investigated. Notably, in nitronyl nitroxide radical-metal systems, the investigation of diverse properties is still scarce so far. This work can pave the way towards the synthesis of multifunctional materials that combine SMM behavior, and optical or/and thermodynamic properties.