However, based on the available toxicological data on oils derived from Schizochytrium sp., the QPS status of the source of the NF, the production process, the composition of the NF and the absence of viable cells in the NF, the Panel considers there are no concerns with regard to toxicity of the NF. The Panel considers that the data provided by the applicant are not sufficient to conclude on the safety of the NF at the proposed uses (3 g DHA/day as a food supplement) in adults. However, in 2012, the Panel concluded that supplemental intakes of DHA alone up to about 1 g/day do not raise safety concerns for the general population. The Panel concludes that the NF is safe for the use in food supplements at the maximum intake level of 1 g DHA/day for the target population (adults, excluding pregnant and lactating women).Limb lengthening by distraction osteogenesis is an accepted orthopaedic surgical technique. The Precice intramedullary lengthening system is the most recent innovation in limb lengthening. Early results have been favourable in femoral lengthening but there is little reported on the outcome in tibial lengthening. The aim of this study is to present our early results of Precice tibial lengthening, and the stepwise evolution of our surgical technique. A case series of 17 consecutive tibial lengthenings were prospectively analysed. Healing index, length achieved, range of motion, and complications were recorded. The initial cases followed the recommended surgical technique. Progressive regenerate deformity during lengthening required changes to the surgical method. No cases were lost to follow-up. All the nails lengthened at the desired rate. There were no complications of infection or poor regenerate formation. Progressive valgus and procurvatum was prevented in later cases by the positioning of Poller blocking screws at the time of nail insertion. The tibial Precice nail is successful in obtaining length and good regenerate formation. The recommended technique was insufficient to control the deforming forces from the lower limb muscle compartments during lengthening. Almonertinib We therefore recommend the addition of multiple blocking screws in an amended technique. Wright SE, Goodier WD, Calder P. Regenerate Deformity with the Precice Tibial Nail. Strategies Trauma Limb Reconstr 2020;15(2)98-105.Wright SE, Goodier WD, Calder P. Regenerate Deformity with the Precice Tibial Nail. Strategies Trauma Limb Reconstr 2020;15(2)98-105. Ilizarov hip reconstruction (IHR) is a traditional method of salvaging chronic adolescent problem hips but faces practical problems from external fixators leading to reduced compliance. We present the same reconstruction utilising only internal devices with a modification in technique and aim to review early results. We retrospectively evaluated eight patients between 2014 and 2017 with chronic painful hips treated by a two-stage reconstruction; stage 1 included femoral head resection and pelvic support osteotomy using double plating, while stage 2 comprised distal femoral osteotomy avoiding varus followed by insertion of retrograde magnetic nail for postoperative lengthening. Patients continued physiotherapy postoperatively while protecting from early weight-bearing. At mean follow-up of 19 months (range 6-36), all osteotomies healed with bone healing index of 47 days/cm (range 30-72). Pain improved from 8.3 (range 7-9) to 2 (range 0-6), while limb length discrepancy got corrected from 4.3 cm (range 3-rt Hip Reconstruction with Internal Devices An Alternative to Ilizarov Hip Reconstruction. Strategies Trauma Limb Reconstr 2020;15(2)91-97.Metikala S, Kurian BT, Madan SS, et al. Pelvic Support Hip Reconstruction with Internal Devices An Alternative to Ilizarov Hip Reconstruction. Strategies Trauma Limb Reconstr 2020;15(2)91-97. Fibular autograft is a known technique for the reconstruction of traumatic and non-traumatic bone defects in both adult and paediatric populations. We aim to describe our outcomes using various stabilisation methods for non-vascularised fibular autograft to reconstruct both benign and malignant tumours in a paediatric population in a National Paediatric Centre over the past 14 years. This was a retrospective review of 10 paediatric cases with non-traumatic primary bone defects in a National Paediatric Centre. Criteria for inclusion were all non-traumatic primary bone defects requiring reconstruction with a non-vascularised fibular autograft in the diaphyseal or metaphyseal regions of the bone. The primary outcome measures were union and time to union (weeks). Time to union was illustrated using Kaplan-Meier curves. Secondary outcome measures included postoperative fracture, infection (deep and superficial), time to full weight-bearing and all-cause revision surgery. The mean length of follow-up was 63 mdate. Non-vascularised fibular autograft is successful in the reconstruction of large bone defects secondary to malignant paediatric bone tumours. Sheridan GA, Cassidy JT, Donnelly A, Non-vascularised Fibular Autograft for Reconstruction of Paediatric Bone Defects An Analysis of 10 Cases. Strategies Trauma Limb Reconstr 2020;15(2)84-90.Sheridan GA, Cassidy JT, Donnelly A, et al. Non-vascularised Fibular Autograft for Reconstruction of Paediatric Bone Defects An Analysis of 10 Cases. Strategies Trauma Limb Reconstr 2020;15(2)84-90. In deformity correction around the knee, the mechanical lateral distal femoral angle (mLDFA) and medial proximal tibial angle (MPTA) are used in surgical planning routinely. While plain radiographs are generally adequate, some surgeons utilise intraoperative arthrograms to visualise the articular contours and assess a younger child's true joint alignment, often with findings that these are discrepant from that measured just using bone alignment. The age cutoff for a discrepancy between the two is not defined. We queried our picture archiving and communication systems (PACS) database for MRIs with a radiological read of "normal" for patients between the ages of 4 and 16 years at the time of the study. Anatomic axes were used to determine the anatomic LDFA (aLDFA) and MPTA angles using end-cartilage and end-bone landmarks independently. We reviewed 116 MRIs, 56% male, with approximately 9 studies per year of age. There were no significant overall differences between aLDFA and MPTA when measured at the bone vs cartilage surfaces ( = 0.