Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Aims & Objective In this work ZnO-nanorod (ZnO-NR) as reusable catalyst promoted Strecker-type reaction of 2,4-dihydroxyacetophenone, isopropenylacetylene, trimethylsilyl cyanide (TMSCN), primary amines and isocyanides carried out at ambient temperature under solvent-free conditions and produced α-amino nitriles benzofuran derivatives in high yields. These synthesized compounds maybe have antioxidant ability. MATERIALS AND METHODS ZnO-NRs in these reactions were prepared according to reaported article. 2,4-dihydroxyacetophenone 1 (2 mmol) and isopropenylacetylene 2 (2 mmol) was mixed and stirred for 30 min in the presence of ZnO-NR (10 mol%) under solvent-free conditions at room temperature. After 30 min primary amine 3 (2 mmol) was added to the mixture gently and the mixture was stirred for 15 min. After this time TMSCN 4 (2 mmol) was added to mixture and stirred for 15 min. After completion of the reaction, as indicated by TLC, isocyanides 5 add to mixture in the presence of catalyst. RESULTS In the first sight© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.This study explains the FT-IR, XRD, XRF, SEM/EDX, TGA, and DSC/DTA characterization of commercially available kaolin clay. selleck compound The kaolin clay was treated with 4M hydrochloric acid. The objective of this paper is to explore the prominent utilization of kandites clay and useful chemical aspects for modification of kaolin clay minerals. The mineral phase in the presence of chlorite, cristobalite, halloysite, and quartz of kaolin clay was identified by XRD. The FT-IR revealed the functional group of Al-O, A1-OH, and Si-O. Elemental analysis was done by the XRF. The main elements of kaolin clay, SiO2, Al2O3, K2O, Fe2O3, and TiO2 were 45.22%, 38.43%, 0.84%, 0.52%, and 0.269% respectively with rest of impurities. Loss on ignition was found 10.89%. The morphology indicates that the presences of large particles are in the form of agglomerates. Fingerprint region of the acid-treated sample has broad and more bending vibrations than untreated samples. The high weight percentage of Ti and CaCO3 were spotted in the scanning electron micrograph by both atomic % and weight %. It was found that impurity like scandium vanished and manganese traced by the same atomic % 0.01 of zinc which had no presence after acid treatment. Thermogravimetric analysis indicates the sharp increments in heat flow in-between temperatures 0°C to 200°C and consequently increments in between 500°C to 550°C, a suitable range for the pyrolysis process. TGA and DTA analysis satisfy the waste plastic valorization temperature ranges. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.BACKGROUND Tomato is considered a model plant in genetics and to be one of the most economically important crops of all those that exist in the world. Several species of fungi are reported on tomato fruit, causing damage both during cultivation and after harvest. Some of appropriate actions that could be initiated to taken to resolve the problem are to develop and search for new antimicrobial substances isolated from bioactive natural product, as essential oils. AIM AND OBJECTIVE The aim of this work was to determine the chemical composition of essential oils of Ammoides verticillata, Allium sativum and Curcuma longa, to evaluate their in-vitro antifungal activities and evaluate in-vivo antifungal effect of essential oils blends in an effort to reduce tomato diseases. MATERIALS AND METHODS The essential oils obtained from aerial parts of plants were analyzed by GC/MS and tested for their antifungal activities against Penicillium expansum, Fusarium solani, Rhizopus stolonifer and Alternaria alternata using thend C. longa essential oil blends can be used as a natural food preservative and alternative to chemical fungicides to protect stored tomato against many phytopathogens. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.BACKGROUND Halogenated corticosteroids are widely used in medicine, and the global needs in these steroidal APIs are estimated in 40 - 70 tons, annually. Vietnam currently imports the pharmaceutical compounds up to 90%, in particular 100% of steroidal drugs. Currently, industrial production is based on the chemical syntheses of corticosteroids from either 16-dehydropregnenolone acetate (obtained from diosgenin) or androstenedione (obtained from phytosterol). The development of shorter synthetic schemes and more economically feasible technologies is of great significance. Introduction of 1(2)-double bond at the final stages of the corticosteroids synthesis resulted in its poor yield. 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione (tetraene acetate) is a key intermediate in the synthesis of highly active halogenated corticosteroids such as dexamethasone and other halogenated corticosteroids. 21-acetoxypregna-1,4,9(11),16-tetraene-3,20-dione, a key intermediate in the synthesis dexamethasone from the readily The results could be applied at the production of the value-added 9-haloidated corticoids. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.BACKGROUND The selective targeting of CREB-cAMP-responsive element-binding protein (CBP) has recently evolved as a vital therapeutic approach for curtailing its aberrant upregulation associated with the development of prostate cancer. Inhibition of CBP has therefore been discovered to be an important therapeutic option in androgen receptor signalling pathway mediated prostate cancer. Y08197, a novel selective inhibitor of CBP has shown promising therapeutic outcome in prostate carcinogenesis over non-selective analogues, CPI-637. METHODS/RESULTS Herein, we used molecular dynamics simulation to gain insights into the mechanistic and selective targeting of Y08197 at the bromodomain active site. Molecular Mechanics/ Poisson-Boltzmann Surface Area (MM/PBSA) analysis revealed similar inhibitory effect between Y08197 and CPI-637. Furthermore, in exploring the selective affinity of Y08197 towards CBP in relative to Bromodomain and PHD finger-containing protein 1(BRPF1), our findings highlighted Asp1116 as the 'culprit' residue responsible for this selective targeting.