High tibial osteotomy for medial-compartment knee osteoarthritis (OA) is an established biological knee reconstruction surgical procedure. In open- and closed-wedge high tibial osteotomy, the angulation correction axes are away from the center of rotation and angulation. This results in translation deformity, which alters the orientation of the adjacent joint and the length of the limb. In the present study, we combined the distal tibial tuberosity focal dome osteotomy centered on the center of rotation and angulation with the longitudinal condylar osteotomy (focal dome condylar osteotomy) for knee OA. The advantages of this procedure are as follows physiological orientation of adjacent joint is achieved; limb length is maintained; joint stabilization in the coronal plane is achieved; patella infra is prevented; sufficient bone contact between the medial and posterior cortex is achieved; early weight-bearing walking is possible; and fibular osteotomy is not required. This study describes the details of the surgical procedure, including our compass cutter for accurate dome osteotomy and the postoperative rehabilitation program for patients with knee OA and moderate-to-severe varus deformity.Injuries to the lateral collateral ligament (LCL) most commonly occur with concomitant cruciate ligament tears. Over the past decade, there has been increased interest in anatomic reconstruction of the posterolateral corner (PLC). Not much attention has been paid to anatomic primary LCL repair given the historically high failure rates of primary repair of lateral sided knee ligaments, but better outcomes can now be expected because of recent developments in additional suture augmentation. The purpose of this Technical Note is to describe the surgical technique of primary distal LCL repair using suture augmentation. Using this procedure, the native ligament is preserved while allowing early mobilization as suture augmentation is protective of the repaired ligament.Hip dysplasia is an important cause of osteoarthritis in young adults. For these patients, conservative treatment is an interesting alternative to arthroplasty. The current literature suggests better clinical and functional outcomes when shelf acetabuloplasty is performed for a moderate joint pinch ( less then 50%) associated with an important external coverage defect of the acetabular cup ( less then 25°). Compared with open surgical procedures, minimally invasive surgical techniques or arthroscopy tend to reduce morbidity. To date, the major intraoperative difficulty remains the positioning of the graft. This Technical Note aims to outline a minimally invasive shelf acetabuloplasty, with optimization of the position of the autologous iliac crest bone graft using 3-dimensional navigation. Chronic periodontitis (CP) and Type 2 diabetes mellitus (T2DM) are chronic diseases affecting the humans and have interrelationship in their pathogenesis. Monitoring the progress with biomarker in these disease is important from treatment outcome point of view. We investigated the association of salivary developmental endothelial locus-1 (Del-1) and interleukin-17 (IL-17) levels in CP and T2DM. Saliva was collected from 17 healthy and 68 patients (divided into 4 groups based on presence or absence of CP and T2DM). Periodontal parameters were recorded at the time of visit. Del-1 and IL-17 levels in unstimulated salivary samples were determined using enzyme-linked immunosorbent assay. Study found the lower levels of salivary Del-1 and higher levels of IL-17 in CP (2.23±2.10ng/mL, 56.54±19.79ng/mL), CCDM ((1.97±1.36ng/mL, 74.74±17.79ng/mL) and CUDM (1.02±0.52ng/mL, 63.84±24.72ng/mL) as compared to healthy individuals (6.54±2.07; 24.47±8.23ng/mL) (p<0.001). Del-1 and IL-17 levels were correlating with inflammatory state in CP and presence of T2DM aggravate the severity of disease in CP. An inverse correlation between salivary Del-1 & IL-17 levels was also seen. selleck inhibitor Furthermore, we also observed that the combination of T2DM and CP (CCDM and CUDM) increases the salivary IL-17 levels and decreases Del-1 levels. There is an upregulation of salivary IL-17 and downregulation of salivary Del-1 with increase in severity of periodontal disease as well as T2DM. Furthermore, the presence of T2DM in chronic periodontitis patients can aggravate the inflammation related periodontal destruction.There is an upregulation of salivary IL-17 and downregulation of salivary Del-1 with increase in severity of periodontal disease as well as T2DM. Furthermore, the presence of T2DM in chronic periodontitis patients can aggravate the inflammation related periodontal destruction. The study evaluated the clinical efficacy of Polyether ether ketone (PEEK) fixed dental prosthesis (FDP) over a period of one year using modified Ryges criteria and California Dental Assessment system. The group consisted of 20 patients restored with posterior three-unit PEEK FDP. Patient recall and clinical examination of the restorations were done at interval of 0, 3, 6, 9 and 12 months. Clinical examination for evaluation of longevity of restorations was done using modified Ryges criteria and California dental assessment system on chipping of the veneered composite, discoloration at the marginal areas, and marginal adaptation, retention, periodontal health and hygiene of PEEK FDP. Radiographic assessment was done after 12 months. Statistical analysis were done using Friedman test. 95% of the patients had maintained the restoration of PEEK FDP without fracture during the study period. 5% patient reported with de-cementation of fixed dental prosthesis. 10% of the PEEK FDP shows marginal discoloration. However, no significant changes were observed during the periodic time interval evaluation in marginal adaptation, oral hygiene status and periodontal health. (p<0.5). PEEK FDP had satisfactory clinical efficacy and acceptable clinical outcome during the observation period of 12 months. No significant radiological changes were observed at the end of 12 months.PEEK FDP had satisfactory clinical efficacy and acceptable clinical outcome during the observation period of 12 months. No significant radiological changes were observed at the end of 12 months.