P2K4/JNK pathway. HNF1AS1/miR-92a-3p/MAP2K4 axis plays important roles in radiotherapy resistance of NSCLC.Most strokes in patients with atrial fibrillation (AF) are thought to arise from thrombus formation in the left atrial appendage (LAA). Assessing the hemodynamics in LAA and left atrium (LA) may provide some insights in the evaluation of the risk of thrombus formation. This study aims to find out the impact of different LAA locations with respect of LA on the risk of thrombus formation within LAA in patients with AF. Three different LAA locations at LA were modeled and a fully coupled fluid-structure interaction analysis was performed. A discrete phase method was used for particle residence analysis to evaluate risk of the thrombus formation. The results showed that LAA positions on the LA affected the LAA flow velocity distribution, passive contraction ability, and particle residence. In particular, the left pulmonary veins (PVs) had a greater influence on the LAA hemodynamics than the right PVs. The LAA had the lowest contractibility when it was located between left superior and left inferior PVs, and in this case, a larger number of particles were resided, which indicated a higher risk of thrombus formation. The present work provides a quantitative way to evaluate the risk of thrombus formation within LAA in patients with AF. Continuous measurement of aortic pressure and aortic flow velocity signals in the operating theatre allows us to draw velocity-pressure (Vel-Pre) loops. The global afterload angle (GALA), derived from the Vel-Pre loops, has been linked to cardiac afterload indicators. As age is the major determinant of constitutive arterial stiffness, we aimed to describe (1) the evolution of the GALA according to age in a large cohort of anesthetized patients and (2) GALA variations induced by haemodynamic interventions. We included patients for whom continuous monitoring of arterial pressure and cardiac output were indicated. Fluid challenges or vasopressors were administered to treat intra-operative hypotension. The primary endpoint was the comparison of the GALA values between young and old patients. The secondary endpoint was the difference in the GALA values before and after haemodynamic interventions. We included 133 anaesthetized patients 66 old and 67 young patients. At baseline, the GALA was higher in the old constriction changes (by vasopressors). In addition, the GALA can discriminate the differential effects of phenylephrine and noradrenaline. These results should be confirmed in a prospective, ideally randomized, trial.This study aimed to investigate the efficacy of intraoperative motor evoked potential (MEP) and somatosensory evoked potential (SSEP) monitoring for predicting postoperative motor deficits (PMDs) in patients with internal carotid artery (ICA) aneurysms. The data for 138 patients with ICA aneurysms who underwent surgical clipping as well as their intraoperative neuromonitoring data were retrospectively reviewed. The efficacy of MEP/SSEP changes for predicting PMDs was assessed using binary logistic regression analysis. Subsequently, receiver operating characteristic curve analysis was used to obtain a supplementary critical value of the MEP/SSEP deterioration duration. The sensitivity and specificity of MEP changes for predicting PMDs were 0.824 and 0.843, respectively. For SSEP changes, the sensitivity and specificity were 0.529 and 0.959, respectively. MEP and SSEP changes were identified as independent predictors for short-term (p = 0.002 and 0.011, respectively) and long-term PMDs (p = 0.040 and 0.006, respectively). The supplementary critical value for MEP deterioration duration for predicting PMDs was 14 min (p = 0.007, AUC = 0.805). GSK3235025 For SSEP, the value was 14.5 min (p = 0.042, AUC = 0.875). The MEP/SSEP changes adjusted by those optimal values were also identified as independent predictors for short-term (p  less then  0.001 and p = 0.005, respectively) and long-term PMDs (p = 0.019 and 0.003, respectively). Intraoperative MEP and SSEP deterioration durations are effective in predicting PMDs in patients with ICA aneurysms.Biomonitoring provides direct evidence of the bioavailability and accumulation of toxic elements in the environment, and homing pigeons have been proposed as a biomonitor of atmospheric pollution. We evaluated metal concentrations in homing pigeon feather tissue as a biomonitoring tool. We measured cadmium, lead, and mercury concentrations in feathers collected from 5-6-yo homing pigeons from Guangzhou, Beijing, and Harbin, China during 2011, and feathers of 1, 5, and 10-yo homing pigeons collected from Guangzhou, Beijing, and Harbin, China during 2015-16. We compared metal concentrations in feathers between sexes and among ages and evaluated spatio-temporal differences. Correlations between feather metal concentrations and previously evaluated kidney and liver metal concentrations are reported. There were no significant differences in feather metal concentrations between male and female pigeons or among 1, 5, and 10-yo pigeons. Cadmium, lead, and mercury concentrations in feathers of 1-yo pigeons were significantly correlated with concentrations in liver and kidney tissues, although the correlations were not consistent. Spatio-temporal differences in feather metal concentrations suggest the usefulness of feathers in identifying areas of concern and remedial effectiveness. Homing pigeon feather metal concentrations appear to be useful as a screening biomonitoring tool.A natural compound with the algicidal effect was isolated from the culture medium of Aspergillus sp. SCSIOW2 and was identified as malformin C, which was based on the data of 1H-NMR, 13C-NMR, and ESI-MS. Malformin C exhibited dose-dependent algicidal activities against two strains of noxious red tide algae, Akashiwo sanguinea and Chattonella marina. The activity against A. sanguinea was stronger than that against C. marina (the algicidal activity of 58 and 36% at 50 μM treatment for 2 h, respectively). Morphology changes including perforation, plasmolysis, and fragmentation of algal cells were observed. Malformin C induced a significant increase in ROS level, caused the damage of SOD activity, and led to the massive generation of MDA contents in algae cells. To our knowledge, this is the first report of the cyclic peptide described as an algicidal compound against HABs.