In conclusion, EAM could improve the SD-evoked learning and memory impairments. The possible underlying mechanisms of EAM may be related to its antioxidant capacity and enhanced BDNF/TrkB/GluR1 levels in the hippocampal memory.Copper(i) complexes [Cu(L1-7)2](ClO4) (1-7) of bidentate ligands (L1-L7) have been synthesized via spontaneous reduction and characterized as catalysts for aromatic C-H activation using H2O2 as the oxidant. The single crystal X-ray structure of 1 exhibited a distorted tetrahedral geometry. All the copper(i) complexes catalyzed direct hydroxylation of benzene to form phenol with good selectivity up to 98%. The determined kinetic isotope effect (KIE) values, 1.69-1.71, support the involvement of a radical type mechanism. The isotope-labeling experiments using H218O2 showed 92% incorporation of 18O into phenol and confirm that H2O2 is the key oxygen supplier. Overall, the catalytic efficiencies of the complexes are strongly influenced by the electronic and steric factor of the ligand, which is fine-tuned by the ligand architecture. The benzene hydroxylation reaction possibly proceeded via a radical mechanism, which was confirmed by the addition of radical scavengers (TEMPO) to the catalytic reaction that showed a reduction in phenol formation.In this work, a solid-state electrochemiluminescence (ECL) sensor based on resonance energy transfer (RET) was proposed using MoS2QDs@g-C3N4 as a donor and NH2-SiO2@PTCA as an acceptor. Herein, MoS2QDs could significantly facilitate the stability and efficiency of the ECL of g-C3N4. PTCA provided a large platform to anchor NH2-SiO2 nanoparticles. The prepared MoS2QDs@g-C3N4 exhibited good spectral overlap with the UV-vis absorption spectrum of NH2-SiO2@PTCA. Based on this, we designed an "off-on" ECL sensing strategy for sensitive and selective detection of glutathione (GSH). Under the best conditions, the linear range of the sensor for GSH detection was from 0.001 to 100 μM with a detection limit of 0.63 nM (S/N = 3). More importantly, GSH in commercial samples can be detected using the proposed sensor, which indicated its superior detection capabilities and potential application value in commercial medicines.In this work, a simple, specific and ultra-sensitive electrochemical aptasensor was successfully developed based on a novel signal reduction strategy for the detection of polychlorinated biphenyls (PCB77). This aptasensor was prepared by the electrodeposition of gold nanoparticles (AuNPs) on an Au electrode (AuE) modified with cobalt phosphide (CoxP, a mixture of CoP and Co2P) decorated porous carbon microspheres. In this study, the thiolated single-complementary DNA (cDNA) was immobilized on the surface of the modified electrode via the Au-S bond. selleck Subsequently, the gold nanorod@methylene blue connection aptamer (AuNRs@MB-Apt) signal labels were immobilized onto the modified electrode through the principle of complementary base pairing. Further, the aptamer preferentially binds to PCB77, decreasing the amount of AuNR@MB-Apt. The DPV current response was related to the PCB77 concentration. Under the optimized experimental conditions, a low detection limit of 5.9 × 10-2 ng L-1 and a wide linear range of 1 × 10-11 mg mL-1 to 1 × 10-4 mg mL-1 (S/N = 3) for PCB77 were achieved. Moreover, the proposed aptasensor offered high selectivity, stability and reproducibility, indicating the broad potential application in environmental monitoring.Non-intrusive detection systems have the potential to characterise materials through various transparent glass and plastic containers. Food and drink adulteration is increasingly problematic, representing a serious health risk as well as an economic issue. This is of particular concern for alcoholic spirits such as Scotch whisky which are often targeted for fraudulent activity. We have developed a Raman system with a novel geometry of excitation and collection, exploiting the beam propagation from an axicon lens, which results in an annular beam at the bottle surface before focusing within the sample. This facilitates the efficient acquisition of Raman signals from the alcoholic spirit contained inside the bottle, while avoiding the collection of auto-fluorescence signals generated by the bottle wall. Therefore, this technique provides a way of non-destructive and non-contact detection to precisely analyse the contents without the requirement to open the bottle.Subcutaneous abscesses caused by drug-resistant pathogens pose a serious challenge to human health. To overcome this problem, herein an acidity-responsive aggregated W/Mo-based polyoxometalate (POM) was developed for photothermal-enhanced chemodynamic antibacterial therapy in the second near-infrared (NIR) region. The POM can self-assemble into larger-sized aggregates with stronger absorption in the NIR region, making it remain in the acidic infected tissue. Furthermore, the hydrogen peroxide at the site of infection can be converted to a hydroxyl radical for chemodynamic therapy (CDT) and simultaneously the glutathione in organisms is consumed by the POM to further enhance the CDT effect. More importantly, under laser irradiation, the hyperthermia produced by the POM not only can kill drug-resistant Staphylococcus aureus, but also enhance the performance of CDT. Benefitting from the inflammatory retention and acidity-responsive photothermal-enhanced CDT properties, the POM exhibits an obvious therapeutic effect against drug-resistant bacterial infection without significant side effects under 1060 nm laser irradiation.A cobalt(i) complex is shown to be capable of both electrocatalytic reduction and hydrogenation of CO2 to formate. Several proposed intermediates are characterized and thus form the basis for a proposed mechanism that allows for the dual reactivity reduction of CO2via H2 addition, and H+/e- equivalents. The work makes use of a novel tris(phosphino) ligand. When a pendent amine is attached to the ligand, no change in catalytic reactivity is observed.This work describes a two-chip acoustofluidic platform for two-dimensional (2D) manipulation of microparticles in a closed microchamber on a reusable surface acoustic wave (SAW) device. This platform comprises two microfabricated chips (1) a detachable silicon superstrate enclosed by a PDMS microfluidic chamber and (2) a reusable SAW device for generating standing SAW (SSAW), which is typically an expensive component. Critical to such a two-chip acoustofluidic platform is the selection of a suitable coupling agent at the interface of the SAW device and superstrate. To this end, we applied a polymer thin film as a coupling agent that balances between acoustic coupling efficiency, stability over time, and reusability. Recycling of the SAW device lowers the cost-barrier for acoustofluidic particle manipulation. The SSAW is transmitted into the silicon superstrate via the coupling agent to form a standing Lamb wave (SLW) to trap and move microparticles. The reported two-chip strategy enables the single-use microfluidic superstrates to avoid chemical and biological contaminations, while maintaining the merits of acoustofluidic manipulation of being noncontact and label-free and applicable to a wide range of microparticles with different shapes, density, polarity, and electrical properties.