It is a challenge to acquire a snapshot image of very high resolutions in both spectral and spatial domain via a single short exposure. In this setting one cannot trade time for spectral resolution, such as via spectral bands scanning. Cameras of color filter arrays (CFA) (e.g., the Bayer mosaic) cannot obtain high spectral resolution. To overcome these difficulties, we propose a new multispectral imaging system that makes random linear broadband measurements of the spectrum via a nanostructured multispectral filter array (MSFA). These MSFA random measurements can be used by sparsity-based recovery algorithms to achieve much higher spectral resolution than conventional CFA cameras, without sacrificing spatial resolution. The key innovation is to jointly exploit both spatial and spectral sparsity properties that are inherent to spectral irradiance of natural objects. Experimental results establish the superior performance of the proposed multispectral imaging system over existing ones.From P-SHG experiments, second-order nonlinear optical anisotropy parameters ρ = χZZZ/χZXX of collagen tissues are calculated assuming the same model of supercoiled collagen fibril characterized by a variable angle θ. Dispersion of experimental ρ values is converted into distribution of θ values based on the wavy nature of collagen fibrils deduced from EM studies. For tendon, the results show that the dispersion of experimental ρ values is mainly due to Poisson photonic shot noise assuming a slight fibrillar undulation with θ = 2.2° ± 1.8°. However for skin and vessels, the dispersion of experimental ρ values is mainly due to a stronger fibrillar undulation with θ = 16.2° ± 1.3°. The results highlight that this undulation is reduced during the development of liver fibrosis therefore, contributing to the rigidity of the tissue.The Backside Absorbing Layer Microscopy (BALM) is a recently introduced surface imaging technique in reflected light with an unprecedented combination of sensitivity and lateral resolution, hence very promising for the development of imaging sensors. This requires to turn BALM images into quantative analyte measurements. The usual way to analyze reflectivity is to compare the optical signal and a numerical model with many adjustable parameters. Here we demonstrate a universal relationship between the sample reflectivity and the physical thickness of the sample, ruled by three measurable quantities. Mapping the physical sample thickness becomes possible whatever the instrument setting and the sample refractive index. Application to kinetic measurements is discussed.Data-driven approaches have been proposed as effective strategies for the inverse design and optimization of photonic structures in recent years. In order to assist data-driven methods for the design of topology of photonic devices, we propose a topological encoding method that transforms photonic structures represented by binary images to a continuous sparse representation. This sparse representation can be utilized for dimensionality reduction and dataset generation, enabling effective analysis and optimization of photonic topologies with data-driven approaches. As a proof of principle, we leverage our encoding method for the design of two dimensional non-paraxial diffractive optical elements with various diffraction intensity distributions. We proved that our encoding method is able to assist machine-learning-based inverse design approaches for accurate and global optimization.We report on a high-power fiber optical frequency comb consisting of a 250-MHz mode-locked fiber laser and a three-stage cascaded fiber chirped-pulse amplification system. After power scaling, the group velocity dispersion and third-order dispersion, generated in fiber stretcher and amplifiers, are compensated by a grism compressor, outputting a 132-W, 180-fs pulse train. The repetition rate and carrier-envelope offset frequency are locked to a Rb clock with the standard deviations of 1.07 and 0.87 mHz, corresponding to the fractional instability of 8.3×10-13 and 1.35×10-19, respectively. Moreover, we investigate the noise characteristics at high average powers, presenting a low-noise property of this high-power fiber OFC.In the terahertz (THz) generation driven by two-color laser pulses, the THz wave radiated from the BBO crystal as the effect of the optical rectification is always assumed to be less and negligible. In this paper, the contribution of the optical rectification in the THz radiation driven by two-color laser pulses has been determined quantitatively, by the crucial factors including BBO crystal rotation angle, the pump power of laser, and the numerical aperture of lens. The experimental and simulation results show that the above related factors have dramatically affected the intensity ratio of the THz waves from the plasma and BBO crystal. It is helpful for understanding the mechanism of THz generation from air plasma.We report on an extended cavity quantum cascade laser based on a cavity resonator integrated grating filter (CRIGF) that acts as both cavity end-reflector and spectral selector. Stable, mode-hop free, single-mode emission around 2150 cm-1 is obtained over large injection current ranges (more than 50 mA) with a typical threshold around 290 mA. A digital frequency tuning over more than 65 cm-1 is obtained by changing the periodicity of the CRIGF ending the extended cavity.The waveguide losses from a range of surface plasmon and double metal waveguides for Ge/Si1-xGex THz quantum cascade laser gain media are investigated at 4.79 THz (62.6 μm wavelength). Double metal waveguides demonstrate lower losses than surface plasmonic guiding with minimum losses for a 10 μm thick active gain region with silver metal of 21 cm-1 at 300 K reducing to 14.5 cm-1 at 10 K. Losses for silicon foundry compatible metals including Al and Cu are also provided for comparison and to provide a guide for gain requirements to enable lasers to be fabricated in commercial silicon foundries. Metabolism inhibitor To allow these losses to be calculated for a range of designs, the complex refractive index of a range of nominally undoped Si1-xGex with x = 0.7, 0.8 and 0.9 and doped Ge heterolayers were extracted from Fourier transform infrared spectroscopy measurements between 0.1 and 10 THz and from 300 K down to 10 K. The results demonstrate losses comparable to similar designs of GaAs/AlGaAs quantum cascade laser plasmon waveguides indicating that a gain threshold of 15.